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Genetics, Vol 147, 1557-1568, Copyright © 1997
INVESTIGATIONS |
The Saccharomyces cerevisiae RAD30 Gene, a Homologue of Escherichia coli dinB and umuC, Is DNA Damage Inducible and Functions in a Novel Error-Free Postreplication Repair Mechanism
J. P. McDonald, A. S. Levine and R. Woodgate
Section on DNA Replication, Repair and Mutagenesis, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-2725
Damage-inducible mutagenesis in prokaryotes is largely dependent upon the activity of the UmuD'C-like proteins. Since many DNA repair processes are structurally and/or functionally conserved between prokaryotes and eukaryotes, we investigated the role of RAD30, a previously uncharacterized Saccharomyces cerevisiae DNA repair gene related to the Escherichia coli dinB, umuC and S. cerevisiae REV1 genes, in UV resistance and UV-induced mutagenesis. Similar to its prokaryotic homologues, RAD30 was found to be damage inducible. Like many S. cerevisiae genes involved in error-prone DNA repair, epistasis analysis clearly places RAD30 in the RAD6 group and rad30 mutants display moderate UV sensitivity reminiscent of rev mutants. However, unlike rev mutants, no defect in UV-induced reversion was seen in rad30 strains. While rad6 and rad18 are both epistatic to rad30, no epistasis was observed with rev1, rev3, rev7 or rad5, all of which are members of the RAD6 epistasis group. These findings suggest that RAD30 participates in a novel error-free repair pathway dependent on RAD6 and RAD18, but independent of REV1, REV3, REV7 and RAD5.
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S. Bärtsch, L. E. Kang, and L. S. Symington RAD51 Is Required for the Repair of Plasmid Double-Stranded DNA Gaps from Either Plasmid or Chromosomal Templates Mol. Cell. Biol., February 15, 2000; 20(4): 1194 - 1205. [Abstract] [Full Text] |
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Y. Murakumo, T. Roth, H. Ishii, D. Rasio, S.-i. Numata, C. M. Croce, and R. Fishel A Human REV7 Homolog That Interacts with the Polymerase zeta Catalytic Subunit hREV3 and the Spindle Assembly Checkpoint Protein hMAD2 J. Biol. Chem., February 11, 2000; 275(6): 4391 - 4397. [Abstract] [Full Text] [PDF] |
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V.L. GERLACH, W.J. FEAVER, P.L. FISCHHABER, J.A. RICHARDSON, L. ARAVIND, E.V. KOONIN, K. BEBENEK, T.A. KUNKEL, and E.C. FRIEDBERG Human DNA Polymerase {kappa}: A Novel DNA Polymerase of Unknown Biological Function Encoded by the DINB1 Gene Cold Spring Harb Symp Quant Biol, January 1, 2000; 65(0): 41 - 50. [Abstract] [PDF] |
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S. PRAKASH, R.E. JOHNSON, M.T. WASHINGTON, L. HARACSKA, C.M. KONDRATICK, and L. PRAKASH Role of Yeast and Human DNA Polymerase {eta} in Error-free Replication of Damaged DNA Cold Spring Harb Symp Quant Biol, January 1, 2000; 65(0): 51 - 60. [Abstract] [PDF] |
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C.W. LAWRENCE, P.E.M. GIBBS, R.S. MURANTE, X.-D. WANG, Z. LI, T.P. MCMANUS, W.G. MCGREGOR, J.R. NELSON, D.C. HINKLE, and V.M. MAHER Roles of DNA Polymerase {zeta} and Rev1 Protein in Eukaryotic Mutagenesis and Translesion Replication Cold Spring Harb Symp Quant Biol, January 1, 2000; 65(0): 61 - 70. [Abstract] [PDF] |
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C. MASUTANI, R. KUSUMOTO, A. YAMADA, M. YUASA, M. ARAKI, T. NOGIMORI, M. YOKOI, T. EKI, S. IWAI, and F. HANAOKA Xeroderma Pigmentosum Variant: From a Human Genetic Disorder to a Novel DNA Polymerase Cold Spring Harb Symp Quant Biol, January 1, 2000; 65(0): 71 - 80. [Abstract] [PDF] |
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M. T. Washington, R. E. Johnson, S. Prakash, and L. Prakash Fidelity and Processivity of Saccharomyces cerevisiae DNA Polymerase eta J. Biol. Chem., December 24, 1999; 274(52): 36835 - 36838. [Abstract] [Full Text] [PDF] |
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N. B. Reuven, G. Arad, A. Maor-Shoshani, and Z. Livneh The Mutagenesis Protein UmuC Is a DNA Polymerase Activated by UmuD', RecA, and SSB and Is Specialized for Translesion Replication J. Biol. Chem., November 5, 1999; 274(45): 31763 - 31766. [Abstract] [Full Text] [PDF] |
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Y. K. Jang, L. Wang, and G. B. Sancar RPH1 and GIS1 Are Damage-Responsive Repressors of PHR1 Mol. Cell. Biol., November 1, 1999; 19(11): 7630 - 7638. [Abstract] [Full Text] [PDF] |
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R. E. Johnson, M. T. Washington, S. Prakash, and L. Prakash Bridging the gap: A family of novel DNA polymerases that replicate faulty DNA PNAS, October 26, 1999; 96(22): 12224 - 12226. [Full Text] [PDF] |
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V. L. Gerlach, L. Aravind, G. Gotway, R. A. Schultz, E. V. Koonin, and E. C. Friedberg Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily PNAS, October 12, 1999; 96(21): 11922 - 11927. [Abstract] [Full Text] [PDF] |
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R. Woodgate A plethora of lesion-replicating DNA polymerases Genes & Dev., September 1, 1999; 13(17): 2191 - 2195. [Full Text] |
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M. Tang, X. Shen, E. G. Frank, M. O'Donnell, R. Woodgate, and M. F. Goodman UmuD'2C is an error-prone DNA polymerase, Escherichia coli pol V PNAS, August 3, 1999; 96(16): 8919 - 8924. [Abstract] [Full Text] [PDF] |
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R. E. Johnson, C. M. Kondratick, S. Prakash, and L. Prakash hRAD30 Mutations in the Variant Form of Xeroderma Pigmentosum Science, July 9, 1999; 285(5425): 263 - 265. [Abstract] [Full Text] |
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