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Genetics, Vol 147, 1469-1485, Copyright © 1997
INVESTIGATIONS |
Marker-Assisted Introgression of Quantitative Trait Loci
F. Hospital and A. Charcosset
Station de Genetique Vegetale, INRA/UPS/INAPG, Ferme du Moulon, 91190 Gif sur Yvette, France
The use of molecular markers for the introgression of one or several superior QTL alleles into a recipient line is investigated using analytic and simulation results. The positions of the markers devoted to the control of the genotype at the QTLs in a ``foreground selection'' step are optimized given the confidence interval of the QTL position. Results demonstrate that using at least three markers per QTL allows a good control over several generations. Population sizes that should be recommended for various numbers of QTLs are calculated and are used to determine the limit in the number of QTLs that can be monitored simultaneously. If ``background selection'' devoted to accelerate the return to the recipient parent genotype outside the QTL regions is applied, the positions of the markers devoted to the control of the QTLs have to be reconsidered. When several QTLs are monitored simultaneously, background selection among the limited number of individuals resulting from the foreground selection step accelerates the increase in genomic similarity with the recipient parent, with only limited costs. Background selection is even more efficient in a pyramidal backcross program where QTLs are first monitored one by one.
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