Genetics, Vol 146, 1489-1499, Copyright © 1997


INVESTIGATIONS

Coalescent Theory for a Partially Selfing Population

Y. X. Fu
Human Genetics Center, University of Texas, Houston, Texas 77225

A coalescent theory for a sample of DNA sequences from a partially selfing diploid population and an algorithm for simulating such samples are developed in this article. Approximate formulas are given for the expectation and the variance of the number of segregating sites in a sample of k sequences from n individuals. Several new estimators of the important parameters {theta} = 4N{mu} and the selfing rate s, where N and {mu} are, respectively, the effective population size and the mutation rate per sequence per generation, are proposed and their sampling properties are studied.


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