A Test of Neutrality Based on Interlocus Associations

INVESTIGATIONS

A Test of Neutrality Based on Interlocus Associations

J. K. Kelly
Present address: John Kelly, Department of Biology, University of Oregon, Eugene, OR 97403-5219. E-mail: jkk@darkwing.uoregon.edu

The evolutionary processes governing variability within genomic regions of low recombination have been the focus of many studies. Here, I investigate the statistical properties of a measure of intrlocus genetic associations under the assumption that mutations are selectively neutral and sites are completely linked. This measure, denoted Z(nS), is based on the squared correlation of allelic identity at pairs of polymorphic sites. Upper bounds for Z(nS) are determined by simulations. Various deviations from the neutral model, including several different forms of natural selection, will inflate the value of Z(nS) relative to its neutral theory expectations. Larger than expected values of Z(nS) are observed in genetic samples from the yellow-ac-scute and Adh regions of Drosophila melanogaster.

This article has been cited by other articles:

J. F. Storz and J. K. Kelly
Effects of Spatially Varying Selection on Nucleotide Diversity and Linkage Disequilibrium: Insights From Deer Mouse Globin Genes
Genetics, September 1, 2008; 180(1): 367 - 379.
[Abstract] [Full Text] [PDF]

P. K. Ingvarsson
Multilocus Patterns of Nucleotide Polymorphism and the Demographic History of Populus tremula
Genetics, September 1, 2008; 180(1): 329 - 340.
[Abstract] [Full Text] [PDF]

J. Vieira, E. Teles, R. A. M. Santos, and C. P. Vieira
Recombination at Prunus S-Locus Region SLFL1 Gene
Genetics, September 1, 2008; 180(1): 483 - 491.
[Abstract] [Full Text] [PDF]

J. E. Pool and R. Nielsen
The Impact of Founder Events on Chromosomal Variability in Multiply Mating Species
Mol. Biol. Evol., August 1, 2008; 25(8): 1728 - 1736.
[Abstract] [Full Text] [PDF]

P. Pfaffelhuber, A. Lehnert, and W. Stephan
Linkage Disequilibrium Under Genetic Hitchhiking in Finite Populations
Genetics, May 1, 2008; 179(1): 527 - 537.
[Abstract] [Full Text] [PDF]

A. Ramirez-Soriano, S. E. Ramos-Onsins, J. Rozas, F. Calafell, and A. Navarro
Statistical Power Analysis of Neutrality Tests Under Demographic Expansions, Contractions and Bottlenecks With Recombination
Genetics, May 1, 2008; 179(1): 555 - 567.
[Abstract] [Full Text] [PDF]

S. Beisswanger and W. Stephan
Evidence that strong positive selection drives neofunctionalization in the tandemly duplicated polyhomeotic genes in Drosophila
PNAS, April 8, 2008; 105(14): 5447 - 5452.
[Abstract] [Full Text] [PDF]

J. J. Cai
PGEToolbox: A Matlab Toolbox for Population Genetics and Evolution
J. Hered., February 29, 2008; (2008) esm127v1.
[Abstract] [Full Text] [PDF]

H. Kuittinen, A. Niittyvuopio, P. Rinne, and O. Savolainen
Natural Variation in Arabidopsis lyrata Vernalization Requirement Conferred by a FRIGIDA Indel Polymorphism
Mol. Biol. Evol., February 1, 2008; 25(2): 319 - 329.
[Abstract] [Full Text] [PDF]

V. Nolte and C. Schlotterer
African Drosophila melanogaster and D. simulans Populations Have Similar Levels of Sequence Variability, Suggesting Comparable Effective Population Sizes
Genetics, January 1, 2008; 178(1): 405 - 412.
[Abstract] [Full Text] [PDF]

A. L. Evans, P. A. Mena, and B. F. McAllister
Positive Selection Near an Inversion Breakpoint on the Neo-X Chromosome of Drosophila americana
Genetics, November 1, 2007; 177(3): 1303 - 1319.
[Abstract] [Full Text] [PDF]

U. Arunyawat, W. Stephan, and T. Stadler
Using Multilocus Sequence Data to Assess Population Structure, Natural Selection, and Linkage Disequilibrium in Wild Tomatoes
Mol. Biol. Evol., October 1, 2007; 24(10): 2310 - 2322.
[Abstract] [Full Text] [PDF]

A. Khan, B. Fux, C. Su, J. P. Dubey, M. L. Darde, J. W. Ajioka, B. M. Rosenthal, and L. D. Sibley
Recent transcontinental sweep of Toxoplasma gondii driven by a single monomorphic chromosome
PNAS, September 11, 2007; 104(37): 14872 - 14877.
[Abstract] [Full Text] [PDF]

S. Hutter, H. Li, S. Beisswanger, D. De Lorenzo, and W. Stephan
Distinctly Different Sex Ratios in African and European Populations of Drosophila melanogaster Inferred From Chromosomewide Single Nucleotide Polymorphism Data
Genetics, September 1, 2007; 177(1): 469 - 480.
[Abstract] [Full Text] [PDF]

J. F. Storz, M. Baze, J. L. Waite, F. G. Hoffmann, J. C. Opazo, and J. P. Hayes
Complex Signatures of Selection and Gene Conversion in the Duplicated Globin Genes of House Mice
Genetics, September 1, 2007; 177(1): 481 - 500.
[Abstract] [Full Text] [PDF]

M. T. Hamblin, M. G. Salas Fernandez, M. R. Tuinstra, W. L. Rooney, and S. Kresovich
Sequence Variation at Candidate Loci in the Starch Metabolism Pathway in Sorghum: Prospects for Linkage Disequilibrium Mapping
Crop Sci., July 16, 2007; 47(S2): S-125 - S-134.
[Abstract] [Full Text] [PDF]

K. Zeng, S. Mano, S. Shi, and C.-I Wu
Comparisons of Site- and Haplotype-Frequency Methods for Detecting Positive Selection
Mol. Biol. Evol., July 1, 2007; 24(7): 1562 - 1574.
[Abstract] [Full Text] [PDF]

C. A. Machado, T. S. Haselkorn, and M. A. F. Noor
Evaluation of the Genomic Extent of Effects of Fixed Inversion Differences on Intraspecific Variation and Interspecific Gene Flow in Drosophila pseudoobscura and D. persimilis
Genetics, March 1, 2007; 175(3): 1289 - 1306.
[Abstract] [Full Text] [PDF]

A. Kawabe, S. Nasuda, and D. Charlesworth
Duplication of Centromeric Histone H3 (HTR12) Gene in Arabidopsis halleri and A. lyrata, Plant Species With Multiple Centromeric Satellite Sequences
Genetics, December 1, 2006; 174(4): 2021 - 2032.
[Abstract] [Full Text] [PDF]

S. Glinka, D. De Lorenzo, and W. Stephan
Evidence of Gene Conversion Associated with a Selective Sweep in Drosophila melanogaster
Mol. Biol. Evol., October 1, 2006; 23(10): 1869 - 1878.
[Abstract] [Full Text] [PDF]

H. Quesada, S. E. Ramos-Onsins, J. Rozas, and M. Aguade
Positive Selection Versus Demography: Evolutionary Inferences Based on an Unusual Haplotype Structure in Drosophila simulans
Mol. Biol. Evol., September 1, 2006; 23(9): 1643 - 1647.
[Abstract] [Full Text] [PDF]

S. Beisswanger, W. Stephan, and D. De Lorenzo
Evidence for a Selective Sweep in the wapl Region of Drosophila melanogaster
Genetics, January 1, 2006; 172(1): 265 - 274.
[Abstract] [Full Text] [PDF]

D. A. Moeller and P. Tiffin
Genetic Diversity and the Evolutionary History of Plant Immunity Genes in Two Species of Zea
Mol. Biol. Evol., December 1, 2005; 22(12): 2480 - 2490.
[Abstract] [Full Text] [PDF]

M. A. Saunders, M. Slatkin, C. Garner, M. F. Hammer, and M. W. Nachman
The Extent of Linkage Disequilibrium Caused by Selection on G6PD in Humans
Genetics, November 1, 2005; 171(3): 1219 - 1229.
[Abstract] [Full Text] [PDF]

L. Ometto, S. Glinka, D. De Lorenzo, and W. Stephan
Inferring the Effects of Demography and Selection on Drosophila melanogaster Populations from a Chromosome-Wide Scan of DNA Variation
Mol. Biol. Evol., October 1, 2005; 22(10): 2119 - 2130.
[Abstract] [Full Text] [PDF]

E. S. Balakirev, V. R. Chechetkin, V. V. Lobzin, and F. J. Ayala
Entropy and GC Content in the {beta}-esterase Gene Cluster of the Drosophila melanogaster Subgroup
Mol. Biol. Evol., October 1, 2005; 22(10): 2063 - 2072.
[Abstract] [Full Text] [PDF]

P. K. Ingvarsson
Molecular Population Genetics of Herbivore-induced Protease Inhibitor Genes in European Aspen (Populus tremula L., Salicaceae)
Mol. Biol. Evol., September 1, 2005; 22(9): 1802 - 1812.
[Abstract] [Full Text] [PDF]

J. M. Cork and M. D. Purugganan
High-Diversity Genes in the Arabidopsis Genome
Genetics, August 1, 2005; 170(4): 1897 - 1911.
[Abstract] [Full Text] [PDF]

T. A. Schlenke and D. J. Begun
Linkage Disequilibrium and Recent Selection at Three Immunity Receptor Loci in Drosophila simulans
Genetics, April 1, 2005; 169(4): 2013 - 2022.
[Abstract] [Full Text] [PDF]

H. Innan, K. Zhang, P. Marjoram, S. Tavare, and N. A. Rosenberg
Statistical Tests of the Coalescent Model Based on the Haplotype Frequency Distribution and the Number of Segregating Sites
Genetics, March 1, 2005; 169(3): 1763 - 1777.
[Abstract] [Full Text] [PDF]

A. Munte, J. Rozas, M. Aguade, and C. Segarra
Chromosomal Inversion Polymorphism Leads to Extensive Genetic Structure: A Multilocus Survey in Drosophila subobscura
Genetics, March 1, 2005; 169(3): 1573 - 1581.
[Abstract] [Full Text] [PDF]

F. Catania and C. Schlotterer
Non-African Origin of a Local Beneficial Mutation in D. melanogaster
Mol. Biol. Evol., February 1, 2005; 22(2): 265 - 272.
[Abstract] [Full Text] [PDF]

Y. Kim and R. Nielsen
Linkage Disequilibrium as a Signature of Selective Sweeps
Genetics, July 1, 2004; 167(3): 1513 - 1524.
[Abstract] [Full Text] [PDF]

S. Casillas and A. Barbadilla
PDA: a pipeline to explore and estimate polymorphism in large DNA databases
Nucleic Acids Res., July 1, 2004; 32(suppl_2): W166 - W169.
[Abstract] [Full Text] [PDF]

E. S. Balakirev and F. J. Ayala
Nucleotide Variation in the tinman and bagpipe Homeobox Genes of Drosophila melanogaster
Genetics, April 1, 2004; 166(4): 1845 - 1856.
[Abstract] [Full Text] [PDF]

T. A. Schlenke and D. J. Begun
Strong selective sweep associated with a transposon insertion in Drosophila simulans
PNAS, February 10, 2004; 101(6): 1626 - 1631.
[Abstract] [Full Text] [PDF]

E. S. Balakirev and F. J. Ayala
Nucleotide Variation of the Est-6 Gene Region in Natural Populations of Drosophila melanogaster
Genetics, December 1, 2003; 165(4): 1901 - 1914.
[Abstract] [Full Text] [PDF]

A. Sanchez-Gracia, M. Aguade, and J. Rozas
Patterns of Nucleotide Polymorphism and Divergence in the Odorant-Binding Protein Genes OS-E and OS-F: Analysis in the Melanogaster Species Subgroup of Drosophila
Genetics, November 1, 2003; 165(3): 1279 - 1288.
[Abstract] [Full Text] [PDF]

J. A. Perez, A. Munte, J. Rozas, C. Segarra, and M. Aguade
Nucleotide Polymorphism in the RpII215 Gene Region of the Insular Species Drosophila guanche: Reduced Efficacy of Weak Selection on Synonymous Variation
Mol. Biol. Evol., November 1, 2003; 20(11): 1867 - 1875.
[Abstract] [Full Text] [PDF]

C. P. Vieira, P. A. Coelho, and J. Vieira
Inferences on the Evolutionary History of the Drosophila americana Polymorphic X/4 Fusion From Patterns of Polymorphism at the X-Linked paralytic and elav Genes
Genetics, August 1, 2003; 164(4): 1459 - 1469.
[Abstract] [Full Text] [PDF]

E. S. Balakirev, V. R. Chechetkin, V. V. Lobzin, and F. J. Ayala
DNA Polymorphism in the {beta}-Esterase Gene Cluster of Drosophila melanogaster
Genetics, June 1, 2003; 164(2): 533 - 544.
[Abstract] [Full Text] [PDF]

B. P. Lazzaro and A. G. Clark
Molecular Population Genetics of Inducible Antibacterial Peptide Genes in Drosophila melanogaster
Mol. Biol. Evol., June 1, 2003; 20(6): 914 - 923.
[Abstract] [Full Text] [PDF]

K. A. Shepard and M. D. Purugganan
Molecular Population Genetics of the Arabidopsis CLAVATA2 Region: The Genomic Scale of Variation and Selection in a Selfing Species
Genetics, March 1, 2003; 163(3): 1083 - 1095.
[Abstract] [Full Text] [PDF]

M. Zurovcova and F. J. Ayala
Polymorphism Patterns in Two Tightly Linked Developmental Genes, Idgf1 and Idgf3, of Drosophila melanogaster
Genetics, September 1, 2002; 162(1): 177 - 188.
[Abstract] [Full Text] [PDF]

U. Lagercrantz, M. Kruskopf Osterberg, and M. Lascoux
Sequence Variation and Haplotype Structure at the Putative Flowering-Time Locus COL1 of Brassica nigra
Mol. Biol. Evol., September 1, 2002; 19(9): 1474 - 1482.
[Abstract] [Full Text] [PDF]

S. Williamson and M. E. Orive
The Genealogy of a Sequence Subject to Purifying Selection at Multiple Sites
Mol. Biol. Evol., August 1, 2002; 19(8): 1376 - 1384.
[Abstract] [Full Text] [PDF]

J. F. Baines, Y. Chen, A. Das, and W. Stephan
DNA Sequence Variation at a Duplicated Gene: Excess of Replacement Polymorphism and Extensive Haplotype Structure in the Drosophila melanogasterbicoid Region
Mol. Biol. Evol., July 1, 2002; 19(7): 989 - 998.
[Abstract] [Full Text] [PDF]

J. M. Comeron and M. Kreitman
Population, Evolutionary and Genomic Consequences of Interference Selection
Genetics, May 1, 2002; 161(1): 389 - 410.
[Abstract] [Full Text] [PDF]

J. Vieira
Two Divergent Species of the Virilis Group, Drosophila littoralis and Drosophila virilis, Share a Replacement Polymorphism at the fused Locus
Mol. Biol. Evol., April 1, 2002; 19(4): 579 - 581.
[Full Text] [PDF]

S. Palsson
Selection on a Modifier of Recombination Rate Due to Linked Deleterious Mutations
J. Hered., January 1, 2002; 93(1): 22 - 26.
[Abstract] [Full Text] [PDF]

D. A. Filatov, V. Laporte, C. Vitte, and D. Charlesworth
DNA Diversity in Sex-Linked and Autosomal Genes of the Plant Species Silene latifolia and Silene dioica
Mol. Biol. Evol., August 1, 2001; 18(8): 1442 - 1454.
[Abstract] [Full Text] [PDF]

J. Rozas, M. Gullaud, G. Blandin, and M. Aguade
DNA Variation at the rp49 Gene Region of Drosophila simulans: Evolutionary Inferences From an Unusual Haplotype Structure
Genetics, July 1, 2001; 158(3): 1147 - 1155.
[Abstract] [Full Text] [PDF]

J. Vieira and B. Charlesworth
Evidence for Selection at the fused Locus of Drosophila virilis
Genetics, August 1, 2000; 155(4): 1701 - 1709.
[Abstract] [Full Text]

D. A. Filatov and D. Charlesworth
DNA Polymorphism, Haplotype Structure and Balancing Selection in the Leavenworthia PgiC Locus
Genetics, November 1, 1999; 153(3): 1423 - 1434.
[Abstract] [Full Text]

P. Awadalla and D. Charlesworth
Recombination and Selection at Brassica Self-Incompatibility Loci
Genetics, May 1, 1999; 152(1): 413 - 425.
[Abstract] [Full Text]

H. Akashi
Inferring the Fitness Effects of DNA Mutations From Polymorphism and Divergence Data: Statistical Power to Detect Directional Selection Under Stationarity and Free Recombination
Genetics, January 1, 1999; 151(1): 221 - 238.
[Abstract] [Full Text]

F. Liu, D. Charlesworth, and M. Kreitman
The Effect of Mating System Differences on Nucleotide Diversity at the Phosphoglucose Isomerase Locus in the Plant Genus Leavenworthia
Genetics, January 1, 1999; 151(1): 343 - 357.
[Abstract] [Full Text]

				P. K. Ingvarsson Multilocus Patterns of Nucleotide Polymorphism and the Demographic History of Populus tremula Genetics, September 1, 2008; 180(1): 329 - 340. [Abstract] [Full Text] [PDF]

				J. Vieira, E. Teles, R. A. M. Santos, and C. P. Vieira Recombination at Prunus S-Locus Region SLFL1 Gene Genetics, September 1, 2008; 180(1): 483 - 491. [Abstract] [Full Text] [PDF]

				J. E. Pool and R. Nielsen The Impact of Founder Events on Chromosomal Variability in Multiply Mating Species Mol. Biol. Evol., August 1, 2008; 25(8): 1728 - 1736. [Abstract] [Full Text] [PDF]

				P. Pfaffelhuber, A. Lehnert, and W. Stephan Linkage Disequilibrium Under Genetic Hitchhiking in Finite Populations Genetics, May 1, 2008; 179(1): 527 - 537. [Abstract] [Full Text] [PDF]

				A. Ramirez-Soriano, S. E. Ramos-Onsins, J. Rozas, F. Calafell, and A. Navarro Statistical Power Analysis of Neutrality Tests Under Demographic Expansions, Contractions and Bottlenecks With Recombination Genetics, May 1, 2008; 179(1): 555 - 567. [Abstract] [Full Text] [PDF]

				S. Beisswanger and W. Stephan Evidence that strong positive selection drives neofunctionalization in the tandemly duplicated polyhomeotic genes in Drosophila PNAS, April 8, 2008; 105(14): 5447 - 5452. [Abstract] [Full Text] [PDF]

				J. J. Cai PGEToolbox: A Matlab Toolbox for Population Genetics and Evolution J. Hered., February 29, 2008; (2008) esm127v1. [Abstract] [Full Text] [PDF]

				H. Kuittinen, A. Niittyvuopio, P. Rinne, and O. Savolainen Natural Variation in Arabidopsis lyrata Vernalization Requirement Conferred by a FRIGIDA Indel Polymorphism Mol. Biol. Evol., February 1, 2008; 25(2): 319 - 329. [Abstract] [Full Text] [PDF]

				V. Nolte and C. Schlotterer African Drosophila melanogaster and D. simulans Populations Have Similar Levels of Sequence Variability, Suggesting Comparable Effective Population Sizes Genetics, January 1, 2008; 178(1): 405 - 412. [Abstract] [Full Text] [PDF]

				A. L. Evans, P. A. Mena, and B. F. McAllister Positive Selection Near an Inversion Breakpoint on the Neo-X Chromosome of Drosophila americana Genetics, November 1, 2007; 177(3): 1303 - 1319. [Abstract] [Full Text] [PDF]

				U. Arunyawat, W. Stephan, and T. Stadler Using Multilocus Sequence Data to Assess Population Structure, Natural Selection, and Linkage Disequilibrium in Wild Tomatoes Mol. Biol. Evol., October 1, 2007; 24(10): 2310 - 2322. [Abstract] [Full Text] [PDF]

				A. Khan, B. Fux, C. Su, J. P. Dubey, M. L. Darde, J. W. Ajioka, B. M. Rosenthal, and L. D. Sibley Recent transcontinental sweep of Toxoplasma gondii driven by a single monomorphic chromosome PNAS, September 11, 2007; 104(37): 14872 - 14877. [Abstract] [Full Text] [PDF]

				S. Hutter, H. Li, S. Beisswanger, D. De Lorenzo, and W. Stephan Distinctly Different Sex Ratios in African and European Populations of Drosophila melanogaster Inferred From Chromosomewide Single Nucleotide Polymorphism Data Genetics, September 1, 2007; 177(1): 469 - 480. [Abstract] [Full Text] [PDF]

				J. F. Storz, M. Baze, J. L. Waite, F. G. Hoffmann, J. C. Opazo, and J. P. Hayes Complex Signatures of Selection and Gene Conversion in the Duplicated Globin Genes of House Mice Genetics, September 1, 2007; 177(1): 481 - 500. [Abstract] [Full Text] [PDF]

				M. T. Hamblin, M. G. Salas Fernandez, M. R. Tuinstra, W. L. Rooney, and S. Kresovich Sequence Variation at Candidate Loci in the Starch Metabolism Pathway in Sorghum: Prospects for Linkage Disequilibrium Mapping Crop Sci., July 16, 2007; 47(S2): S-125 - S-134. [Abstract] [Full Text] [PDF]

				K. Zeng, S. Mano, S. Shi, and C.-I Wu Comparisons of Site- and Haplotype-Frequency Methods for Detecting Positive Selection Mol. Biol. Evol., July 1, 2007; 24(7): 1562 - 1574. [Abstract] [Full Text] [PDF]

				C. A. Machado, T. S. Haselkorn, and M. A. F. Noor Evaluation of the Genomic Extent of Effects of Fixed Inversion Differences on Intraspecific Variation and Interspecific Gene Flow in Drosophila pseudoobscura and D. persimilis Genetics, March 1, 2007; 175(3): 1289 - 1306. [Abstract] [Full Text] [PDF]

				A. Kawabe, S. Nasuda, and D. Charlesworth Duplication of Centromeric Histone H3 (HTR12) Gene in Arabidopsis halleri and A. lyrata, Plant Species With Multiple Centromeric Satellite Sequences Genetics, December 1, 2006; 174(4): 2021 - 2032. [Abstract] [Full Text] [PDF]

				S. Glinka, D. De Lorenzo, and W. Stephan Evidence of Gene Conversion Associated with a Selective Sweep in Drosophila melanogaster Mol. Biol. Evol., October 1, 2006; 23(10): 1869 - 1878. [Abstract] [Full Text] [PDF]

				H. Quesada, S. E. Ramos-Onsins, J. Rozas, and M. Aguade Positive Selection Versus Demography: Evolutionary Inferences Based on an Unusual Haplotype Structure in Drosophila simulans Mol. Biol. Evol., September 1, 2006; 23(9): 1643 - 1647. [Abstract] [Full Text] [PDF]

				S. Beisswanger, W. Stephan, and D. De Lorenzo Evidence for a Selective Sweep in the wapl Region of Drosophila melanogaster Genetics, January 1, 2006; 172(1): 265 - 274. [Abstract] [Full Text] [PDF]

				D. A. Moeller and P. Tiffin Genetic Diversity and the Evolutionary History of Plant Immunity Genes in Two Species of Zea Mol. Biol. Evol., December 1, 2005; 22(12): 2480 - 2490. [Abstract] [Full Text] [PDF]

				M. A. Saunders, M. Slatkin, C. Garner, M. F. Hammer, and M. W. Nachman The Extent of Linkage Disequilibrium Caused by Selection on G6PD in Humans Genetics, November 1, 2005; 171(3): 1219 - 1229. [Abstract] [Full Text] [PDF]

				L. Ometto, S. Glinka, D. De Lorenzo, and W. Stephan Inferring the Effects of Demography and Selection on Drosophila melanogaster Populations from a Chromosome-Wide Scan of DNA Variation Mol. Biol. Evol., October 1, 2005; 22(10): 2119 - 2130. [Abstract] [Full Text] [PDF]

				E. S. Balakirev, V. R. Chechetkin, V. V. Lobzin, and F. J. Ayala Entropy and GC Content in the {beta}-esterase Gene Cluster of the Drosophila melanogaster Subgroup Mol. Biol. Evol., October 1, 2005; 22(10): 2063 - 2072. [Abstract] [Full Text] [PDF]

				P. K. Ingvarsson Molecular Population Genetics of Herbivore-induced Protease Inhibitor Genes in European Aspen (Populus tremula L., Salicaceae) Mol. Biol. Evol., September 1, 2005; 22(9): 1802 - 1812. [Abstract] [Full Text] [PDF]

				J. M. Cork and M. D. Purugganan High-Diversity Genes in the Arabidopsis Genome Genetics, August 1, 2005; 170(4): 1897 - 1911. [Abstract] [Full Text] [PDF]

				T. A. Schlenke and D. J. Begun Linkage Disequilibrium and Recent Selection at Three Immunity Receptor Loci in Drosophila simulans Genetics, April 1, 2005; 169(4): 2013 - 2022. [Abstract] [Full Text] [PDF]

				H. Innan, K. Zhang, P. Marjoram, S. Tavare, and N. A. Rosenberg Statistical Tests of the Coalescent Model Based on the Haplotype Frequency Distribution and the Number of Segregating Sites Genetics, March 1, 2005; 169(3): 1763 - 1777. [Abstract] [Full Text] [PDF]

				A. Munte, J. Rozas, M. Aguade, and C. Segarra Chromosomal Inversion Polymorphism Leads to Extensive Genetic Structure: A Multilocus Survey in Drosophila subobscura Genetics, March 1, 2005; 169(3): 1573 - 1581. [Abstract] [Full Text] [PDF]