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Genetics, Vol 146, 607-618, Copyright © 1997
INVESTIGATIONS |
Genetic and Molecular Analysis of smooth, a Quantitative Trait Locus Affecting Bristle Number in Drosophila melanogaster
P. Z. Lage, A. D. Shrimpton, A. J. Flavell, TFC. Mackay and AJL. Brown
Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JN, Scotland Present address: Institute of Molecular and Cellular Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland.
A semi-lethal, sterile allele of the smooth locus (2-91.5), sm(3), was discovered in an artificial selection line for low abdominal bristle number that had been started from a P-M dysgenic cross. The fitness effects and extremely low bristle number phenotype of the allele could not be separated by recombination from a P-element insertion at cytological location 56E, and precise excision of the P element at this site was associated with reversion to wild type. The smooth gene was cloned using the P-element insertion as a tag. The gene encodes a 2.6-kb transcript derived from 10 exons and covers a genomic region of at least 80 kb. The Drosophila smooth gene shares substantial sequence identity with a group of RNA binding proteins, with the closest relationship being to the human heterogeneous nuclear ribonucleoprotein L gene. The smooth gene is by definition an abdominal bristle number quantitative trait locus, but further work is required to discern whether naturally occurring allelic variation at this locus is a source of genetic variation for abdominal bristle number in natural populations.
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