Genetics, Vol 145, 1093-1108, Copyright © 1997


INVESTIGATIONS

Impact of Migration and Fitness on the Stability of Lethal t-Haplotype Polymorphism in Mus musculus: A Computer Study

D. Durand, K. Ardlie, L. Buttel, S. A. Levin and L. M. Silver
Computational Biology Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6228 and DIMACS, Rutgers University, Piscataway, New Jersey 08855-1179

The t-haplotype is a chromosomal region in Mus musculus characterized by meiotic drive such that heterozygous males transmit t-bearing chromosomes to roughly 90% of their offspring. Most naturally occurring t-haplotypes express a recessive embryonic lethality, preventing fixation of the t-haplotype. Surprisingly, the t-haplotype occurs in nature as a persistent, low-frequency polymorphism. Early modeling studies led LEWONTIN to hypothesize that this low level polymorphism results from a balance between genetic drift in small demes and interdemic migration. Here, we show that while combinations of deme size and migration rate that predict natural t-haplotype frequencies exist, the range of such values is too narrow to be biologically plausible, suggesting that small deme size and interdemic migration alone do not explain the observed t-haplotype frequencies. In response, we tested other factors that might explain the observed t-polymorphism. Two led to biologically plausible models: substantially reduced heterozygous fitness and reduced meiotic drive. This raises the question whether these phenomena occur in nature. Our data suggest an alternative explanation: there is no stable, low-level t-polymorphism. Rather wild populations are in one of two stable states characterized by extinction of the t-haplotype and a high t-haplotype frequency, respectively, or in transition between the two.