- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Saavedra, C.
- Articles by Zouros, E.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Saavedra, C.
- Articles by Zouros, E.
Genetics, Vol 145, 1073-1082, Copyright © 1997
INVESTIGATIONS |
Male-Dependent Doubly Uniparental Inheritance of Mitochondrial DNA and Female-Dependent Sex-Ratio in the Mussel Mytilus galloprovincialis
C. Saavedra, M. I. Reyero and E. Zouros
Department of Biology, University of Crete and Institute of Marine Biology of Crete, Iraklio, Crete, Greece
We have investigated sex ratio and mitochondrial DNA inheritance in pair-matings involving five female and five male individuals of the Mediterranean mussel Mytilus galloprovincialis. The percentage of male progeny varied widely among families and was found to be a characteristic of the female parent and independent of the male to which it was mated. Thus sex-ratio in Mytilus appears to be independent of the nuclear genotype of the sperm. With a few exceptions, doubly uniparental inheritance (DUI) of mtDNA was observed in all families fathered by four of the five males: female and male progeny contained the mother's mtDNA (the F genome), but males contained also the father's paternal mtDNA (the M genome). Two hermaphrodite individuals found among the progeny of these crosses contained the F mitochondrial genome in the female gonad and both the F and M genomes in the male gonad. All four families fathered by the fifth male showed the standard maternal inheritance (SMI) of animal mtDNA: both female and male progeny contained only the maternal mtDNA. These observations illustrate the intimate linkage between sex and mtDNA inheritance in species with DUI and suggest different major roles for each gender. We propose a model according to which development of a male gonad requires the presence in the early germ cells of an agent associated with sperm-derived mitochondria, these mitochondria are endowed with a paternally encoded replicative advantage through which they overcome their original minority in the fertilized egg and this advantage (and, therefore, the chance of an early entrance into the germ line) is countered by a maternally encoded egg factor.
This article has been cited by other articles:
 |
|
 |
|
  I. Theologidis, C. Saavedra, and E. Zouros No Evidence for Absence of Paternal mtDNA in Male Progeny From Pair Matings of the Mussel Mytilus galloprovincialis Genetics, June 1, 2007; 176(2): 1367 - 1369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yusa Nuclear Sex-Determining Genes Cause Large Sex-Ratio Variation in the Apple Snail Pomacea canaliculata Genetics, January 1, 2007; 175(1): 179 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Burzynski, M. Zbawicka, D. O. F. Skibinski, and R. Wenne Doubly Uniparental Inheritance Is Associated With High Polymorphism for Rearranged and Recombinant Control Region Haplotypes in Baltic Mytilus trossulus Genetics, November 1, 2006; 174(3): 1081 - 1094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Breton, G. Burger, D. T. Stewart, and P. U. Blier Comparative Analysis of Gender-Associated Complete Mitochondrial Genomes in Marine Mussels (Mytilus spp.) Genetics, February 1, 2006; 172(2): 1107 - 1119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Mizi, E. Zouros, N. Moschonas, and G. C. Rodakis The Complete Maternal and Paternal Mitochondrial Genomes of the Mediterranean Mussel Mytilus galloprovincialis: Implications for the Doubly Uniparental Inheritance Mode of mtDNA Mol. Biol. Evol., April 1, 2005; 22(4): 952 - 967. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cao, E. Kenchington, and E. Zouros Differential Segregation Patterns of Sperm Mitochondria in Embryos of the Blue Mussel (Mytilus edulis) Genetics, February 1, 2004; 166(2): 883 - 894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Hamilton and J. R. Miller Comparing Relative Rates of Pollen and Seed Gene Flow in the Island Model Using Nuclear and Organelle Measures of Population Structure Genetics, December 1, 2002; 162(4): 1897 - 1909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Grande, J. Templado, J. Lucas Cervera, and R. Zardoya The Complete Mitochondrial Genome of the Nudibranch Roboastra europaea (Mollusca: Gastropoda) Supports the Monophyly of Opisthobranchs Mol. Biol. Evol., October 1, 2002; 19(10): 1672 - 1685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kenchington, B. MacDonald, L. Cao, D. Tsagkarakis, and E. Zouros Genetics of Mother-Dependent Sex Ratio in Blue Mussels (Mytilus spp.) and Implications for Doubly Uniparental Inheritance of Mitochondrial DNA Genetics, August 1, 2002; 161(4): 1579 - 1588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Curole and T. D. Kocher Ancient Sex-Specific Extension of the Cytochrome c Oxidase II Gene in Bivalves and the Fidelity of Doubly-Uniparental Inheritance Mol. Biol. Evol., August 1, 2002; 19(8): 1323 - 1328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Ladoukakis and E. Zouros Direct Evidence for Homologous Recombination in Mussel (Mytilus galloprovincialis) Mitochondrial DNA Mol. Biol. Evol., July 1, 2001; 18(7): 1168 - 1175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
The Fate of Paternal Mitochondrial DNA in Developing Female Mussels, Mytilus edulis: Implications for the Mechanism of Doubly Uniparental Inheritance of Mitochondrial DNA Genetics, January 1, 1998; 148(1): 341 - 348.
|
|