Genetics, Vol 144, 1769-1776, Copyright © 1996

INVESTIGATIONS

Mom1 is a Semi-Dominant Modifier of Intestinal Adenoma Size and Multiplicity in Min/+ Mice

K. A. Gould, W. F. Dietrich, N. Borenstein, E. S. Lander and W. F. Dove
McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706 Present address: Department of Pharmacology, University of Wisconsin, Madison, WI 53706.

The intestinal tumor multiplicity in mice heterozygous for Apc(Min) is strongly modulated by genetic background. On the sensitive C57BL/6J (B6) background, mice develop large numbers of intestinal adenomas. The AKR/J (AKR) strain carries alleles that correlate with a strong reduction in tumor multiplicity. To study the effect of one of these modifiers, Mom1, we have generated a mouse line in which the AKR allele of Mom1 is carried on the sensitive B6 genetic background. This strain was produced by using a marker-assisted selection method to eliminate unlinked AKR alleles more rapidly. The application and efficiency of this method are discussed. We used this strain to determine that Mom1 affects both tumor multiplicity and tumor size in a semi-dominant fashion.

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