Genetics, Vol 144, 1673-1679, Copyright © 1996

INVESTIGATIONS

The Autosomal FLP-DFS Technique for Generating Germline Mosaics in Drosophila melanogaster

T. B. Chou and N. Perrimon
Present address: Department of Zoology, National Taiwan University, Taipei, Taiwan.

The production of female germline chimeras is invaluable for analyzing the tissue specificity of recessive female sterile mutations as well as detecting the maternal effect of recessive zygotic lethal mutations. Previously, we developed the ``FLP-DFS'' technique to efficiently generate germline clones. This technique uses the X-linked germline-dependent dominant female sterile mutation ovo(D1) as a selection for the detection of germline recombination events, and the FLP-FRT recombination system to promote site-specific chromosomal exchange. This method allows the efficient production of germline mosaics only on the X chromosome. In this paper we have built chromosomes that allow the use of this technique to the autosomes. We describe the various steps involved in the development of this technique as well as the properties of the chromosomes utilized.


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J. Z. Maines, L. M. Stevens, X. Tong, and D. Stein
Drosophila dMyc is required for ovary cell growth and endoreplication
Development, February 15, 2004; 131(4): 775 - 786.
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L. Gong, M. Puri, M. Unlu, M. Young, K. Robertson, S. Viswanathan, A. Krishnaswamy, S. R. Dowd, and J. S. Minden
Drosophila ventral furrow morphogenesis: a proteomic analysis
Development, February 1, 2004; 131(3): 643 - 656.
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C. Han, T. Y. Belenkaya, B. Wang, and X. Lin
Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process
Development, February 1, 2004; 131(3): 601 - 611.
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M. Kim, G.-H. Cha, S. Kim, J. H. Lee, J. Park, H. Koh, K.-Y. Choi, and J. Chung
MKP-3 Has Essential Roles as a Negative Regulator of the Ras/Mitogen-Activated Protein Kinase Pathway during Drosophila Development
Mol. Cell. Biol., January 15, 2004; 24(2): 573 - 583.
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M. Murthy and T. L. Schwarz
The exocyst component Sec5 is required for membrane traffic and polarity in the Drosophila ovary
Development, January 15, 2004; 131(2): 377 - 388.
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L. M. Escudero, S.-Y. Wei, W.-H. Chiu, J. Modolell, and J.-C. Hsu
Echinoid synergizes with the Notch signaling pathway in Drosophila mesothorax bristle patterning
Development, December 22, 2003; 130(25): 6305 - 6316.
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T. Gupta and T. Schupbach
Cct1, a phosphatidylcholine biosynthesis enzyme, is required for Drosophila oogenesis and ovarian morphogenesis
Development, December 15, 2003; 130(24): 6075 - 6087.
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B. Laundrie, J. S. Peterson, J. S. Baum, J. C. Chang, D. Fileppo, S. R. Thompson, and K. McCall
Germline Cell Death Is Inhibited by P-Element Insertions Disrupting the dcp-1/pita Nested Gene Pair in Drosophila
Genetics, December 1, 2003; 165(4): 1881 - 1888.
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C. B. Yohn, L. Pusateri, V. Barbosa, and R. Lehmann
l(3)malignant brain tumor and Three Novel Genes Are Required for Drosophila Germ-Cell Formation
Genetics, December 1, 2003; 165(4): 1889 - 1900.
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D. J. Sutherland, M. Li, X.-q. Liu, R. Stefancsik, and L. A. Raftery
Stepwise formation of a SMAD activity gradient during dorsal-ventral patterning of the Drosophila embryo
Development, December 1, 2003; 130(23): 5705 - 5716.
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S. S. Blair
Genetic mosaic techniques for studying Drosophila development
Development, November 1, 2003; 130(21): 5065 - 5072.
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P. Carrera, Y. M. Moshkin, S. Gronke, H. H.W. Sillje, E. A. Nigg, H. Jackle, and F. Karch
Tousled-like kinase functions with the chromatin assembly pathway regulating nuclear divisions
Genes & Dev., October 15, 2003; 17(20): 2578 - 2590.
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T. Sasamura, N. Sasaki, F. Miyashita, S. Nakao, H. O. Ishikawa, M. Ito, M. Kitagawa, K. Harigaya, E. Spana, D. Bilder, et al.
neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions
Development, October 15, 2003; 130(20): 4785 - 4795.
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S. M. Paul, M. Ternet, P. M. Salvaterra, and G. J. Beitel
The Na+/K+ ATPase is required for septate junction function and epithelial tube-size control in the Drosophila tracheal system
Development, October 15, 2003; 130(20): 4963 - 4974.
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