- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Balakirev, E. S.
- Articles by Ayala, F. J.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Balakirev, E. S.
- Articles by Ayala, F. J.
Genetics, Vol 144, 1511-1518, Copyright © 1996
INVESTIGATIONS |
Is Esterase-P Encoded by a Cryptic Pseudogene In Drosophila melanogaster?
E. S. Balakirev and F. J. Ayala
Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92697-2525
We have amplified and sequenced the gene encoding Esterase-P (Est-P) in 10 strains of Drosophila melanogaster. Three premature termination codons occur in the coding region of the gene in two strains. This observation, together with other indirect evidence, leads us to propose that Est-P may be a pseudogene in D. melanogaster. Est-P would be a ``cryptic'' pseudogene, in the sense that it retains intact the coding sequence (without stop codons and other alterations usually observed in pseudogenes) in most D. melanogaster strains. We conjecture that the {beta}-esterase cluster may consist in other Drosophila species of functional and nonfunctional genes. We also conjecture that the rarity of detected pseudogenes in Drosophila may be due to the difficulty of discovering them, because most of them are cryptic.
This article has been cited by other articles:
 |
|
 |
|
  E. S. Balakirev, V. R. Chechetkin, V. V. Lobzin, and F. J. Ayala Entropy and GC Content in the {beta}-esterase Gene Cluster of the Drosophila melanogaster Subgroup Mol. Biol. Evol., October 1, 2005; 22(10): 2063 - 2072. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Balakirev and F. J. Ayala Nucleotide Variation in the tinman and bagpipe Homeobox Genes of Drosophila melanogaster Genetics, April 1, 2004; 166(4): 1845 - 1856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Balakirev and F. J. Ayala Nucleotide Variation of the Est-6 Gene Region in Natural Populations of Drosophila melanogaster Genetics, December 1, 2003; 165(4): 1901 - 1914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Balakirev, V. R. Chechetkin, V. V. Lobzin, and F. J. Ayala DNA Polymorphism in the {beta}-Esterase Gene Cluster of Drosophila melanogaster Genetics, June 1, 2003; 164(2): 533 - 544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Balakirev, E. I. Balakirev, F. Rodríguez-Trelles, and F. J. Ayala Molecular Evolution of Two Linked Genes, Est-6 and Sod, in Drosophila melanogaster Genetics, November 1, 1999; 153(3): 1357 - 1369. [Abstract] [Full Text]
|
|
|
|
|
|
S. Ramos-Onsins and M. Aguadé Molecular Evolution of the Cecropin Multigene Family in Drosophila: Functional Genes vs. Pseudogenes Genetics, September 1, 1998; 150(1): 157 - 171. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. R. Hudson, A. G. Saez, and F. J. Ayala DNA variation at the Sod locus of Drosophila melanogaster: An unfolding story of natural selection PNAS, July 22, 1997; 94(15): 7725 - 7729. [Abstract] [Full Text] [PDF]
|
|