Saccharomyces cerevisiae S288C Has a Mutation in FLO8, a Gene Required for Filamentous Growth

INVESTIGATIONS

Saccharomyces cerevisiae S288C Has a Mutation in FLO8, a Gene Required for Filamentous Growth

H. Liu, C. A. Styles and G. R. Fink
Department of Biological Chemistry, College of Medicine, University of California, Irvine, California 92717

Diploid strains of baker's yeast Saccharomyces cerevisiae can grow in a cellular yeast form or in filaments called pseudohyphae. This dimorphic transition from yeast to pseudohyphae is induced by starvation for nitrogen. Not all laboratory strains are capable of this dimorphic switch; many grow only in the yeast form and fail to form pseudohyphae when starved for nitrogen. Analysis of the standard laboratory strain S288C shows that this defect in dimorphism results from a nonsense mutation in the FLO8 gene. This defect in FLO8 blocks pseudohyphal growth in diploids, haploid invasive growth, and flocculation. Since feral strains of S. cerevisiae are dimorphic and have a functional FLO8 gene, we suggest that the flo8 mutation was selected during laboratory cultivation.

This article has been cited by other articles:

L. N. Dimitrov, R. B. Brem, L. Kruglyak, and D. E. Gottschling
Polymorphisms in Multiple Genes Contribute to the Spontaneous Mitochondrial Genome Instability of Saccharomyces cerevisiae S288C Strains
Genetics, September 1, 2009; 183(1): 365 - 383.
[Abstract] [Full Text] [PDF]

J. Dodgson, H. Avula, K.-L. Hoe, D.-U. Kim, H.-O. Park, J. Hayles, and J. Armstrong
Functional Genomics of Adhesion, Invasion, and Mycelial Formation in Schizosaccharomyces pombe
Eukaryot. Cell, August 1, 2009; 8(8): 1298 - 1306.
[Abstract] [Full Text] [PDF]

X. Mao, X. Nie, F. Cao, and J. Chen
Functional analysis of ScSwi1 and CaSwi1 in invasive and pseudohyphal growth of Saccharomyces cerevisiae
Acta Biochim Biophys Sin, July 1, 2009; 41(7): 594 - 602.
[Abstract] [Full Text] [PDF]

L. A. Strawn, C. A. Lin, E. M.H. Tank, M. M. Osman, S. A. Simpson, and H. L. True
Mutants of the Paf1 Complex Alter Phenotypic Expression of the Yeast Prion [PSI+]
Mol. Biol. Cell, April 15, 2009; 20(8): 2229 - 2241.
[Abstract] [Full Text] [PDF]

P. Govender, J. L. Domingo, M. C. Bester, I. S. Pretorius, and F. F. Bauer
Controlled Expression of the Dominant Flocculation Genes FLO1, FLO5, and FLO11 in Saccharomyces cerevisiae
Appl. Envir. Microbiol., October 1, 2008; 74(19): 6041 - 6052.
[Abstract] [Full Text] [PDF]

O. A. Zill and J. Rine
Interspecies variation reveals a conserved repressor of {alpha}-specific genes in Saccharomyces yeasts
Genes & Dev., June 15, 2008; 22(12): 1704 - 1716.
[Abstract] [Full Text] [PDF]

F. Li and S. P. Palecek
Distinct domains of the Candida albicans adhesin Eap1p mediate cell-cell and cell-substrate interactions
Microbiology, April 1, 2008; 154(4): 1193 - 1203.
[Abstract] [Full Text] [PDF]

L. M. Douglas, L. Li, Y. Yang, and A. M. Dranginis
Expression and Characterization of the Flocculin Flo11/Muc1, a Saccharomyces cerevisiae Mannoprotein with Homotypic Properties of Adhesion
Eukaryot. Cell, December 1, 2007; 6(12): 2214 - 2221.
[Abstract] [Full Text] [PDF]

Y. Li, C. Su, X. Mao, F. Cao, and J. Chen
Roles of Candida albicans Sfl1 in Hyphal Development
Eukaryot. Cell, November 1, 2007; 6(11): 2112 - 2121.
[Abstract] [Full Text] [PDF]

A. Gacser, F. Stehr, C. Kroger, L. Kredics, W. Schafer, and J. D. Nosanchuk
Lipase 8 Affects the Pathogenesis of Candida albicans
Infect. Immun., October 1, 2007; 75(10): 4710 - 4718.
[Abstract] [Full Text] [PDF]

J. Ma, R. Jin, X. Jia, C. J. Dobry, L. Wang, F. Reggiori, J. Zhu, and A. Kumar
An Interrelationship Between Autophagy and Filamentous Growth in Budding Yeast
Genetics, September 1, 2007; 177(1): 205 - 214.
[Abstract] [Full Text] [PDF]

W. V. Gilbert, K. Zhou, T. K. Butler, and J. A. Doudna
Cap-Independent Translation Is Required for Starvation-Induced Differentiation in Yeast
Science, August 31, 2007; 317(5842): 1224 - 1227.
[Abstract] [Full Text] [PDF]

W. Wei, J. H. McCusker, R. W. Hyman, T. Jones, Y. Ning, Z. Cao, Z. Gu, D. Bruno, M. Miranda, M. Nguyen, et al.
Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789
PNAS, July 31, 2007; 104(31): 12825 - 12830.
[Abstract] [Full Text] [PDF]

Y.-U. Park, H. Hur, M. Ka, and J. Kim
Identification of Translational Regulation Target Genes during Filamentous Growth in Saccharomyces cerevisiae: Regulatory Role of Caf20 and Dhh1
Eukaryot. Cell, December 1, 2006; 5(12): 2120 - 2127.
[Abstract] [Full Text] [PDF]

T. K. Ezov, E. Boger-Nadjar, Z. Frenkel, I. Katsperovski, S. Kemeny, E. Nevo, A. Korol, and Y. Kashi
Molecular-Genetic Biodiversity in a Natural Population of the Yeast Saccharomyces cerevisiae From "Evolution Canyon": Microsatellite Polymorphism, Ploidy and Controversial Sexual Status
Genetics, November 1, 2006; 174(3): 1455 - 1468.
[Abstract] [Full Text] [PDF]

V. Voynov, K. J. Verstrepen, A. Jansen, V. M. Runner, S. Buratowski, and G. R. Fink
Genes with internal repeats require the THO complex for transcription
PNAS, September 26, 2006; 103(39): 14423 - 14428.
[Abstract] [Full Text] [PDF]

J. Ronald, H. Tang, and R. B. Brem
Genomewide Evolutionary Rates in Laboratory and Wild Yeast
Genetics, September 1, 2006; 174(1): 541 - 544.
[Abstract] [Full Text] [PDF]

G. Huang, H. Wang, S. Chou, X. Nie, J. Chen, and H. Liu
From the Cover: Bistable expression of WOR1, a master regulator of white-opaque switching in Candida albicans
PNAS, August 22, 2006; 103(34): 12813 - 12818.
[Abstract] [Full Text] [PDF]

M. J. Brauer, C. M. Christianson, D. A. Pai, and M. J. Dunham
Mapping Novel Traits by Array-Assisted Bulk Segregant Analysis in Saccharomyces cerevisiae
Genetics, July 1, 2006; 173(3): 1813 - 1816.
[Abstract] [Full Text] [PDF]

A. R. Borneman, J. A. Leigh-Bell, H. Yu, P. Bertone, M. Gerstein, and M. Snyder
Target hub proteins serve as master regulators of development in yeast
Genes & Dev., February 15, 2006; 20(4): 435 - 448.
[Abstract] [Full Text] [PDF]

F. Cao, S. Lane, P. P. Raniga, Y. Lu, Z. Zhou, K. Ramon, J. Chen, and H. Liu
The Flo8 Transcription Factor Is Essential for Hyphal Development and Virulence in Candida albicans
Mol. Biol. Cell, January 1, 2006; 17(1): 295 - 307.
[Abstract] [Full Text] [PDF]

A. Trott, L. Shaner, and K. A. Morano
The Molecular Chaperone Sse1 and the Growth Control Protein Kinase Sch9 Collaborate to Regulate Protein Kinase A Activity in Saccharomyces cerevisiae
Genetics, July 1, 2005; 170(3): 1009 - 1021.
[Abstract] [Full Text] [PDF]

S. Zara, A. T. Bakalinsky, G. Zara, G. Pirino, M. A. Demontis, and M. Budroni
FLO11-Based Model for Air-Liquid Interfacial Biofilm Formation by Saccharomyces cerevisiae
Appl. Envir. Microbiol., June 1, 2005; 71(6): 2934 - 2939.
[Abstract] [Full Text] [PDF]

L. J. Flatauer, S. F. Zadeh, and L. Bardwell
Mitogen-Activated Protein Kinases with Distinct Requirements for Ste5 Scaffolding Influence Signaling Specificity in Saccharomyces cerevisiae
Mol. Cell. Biol., March 1, 2005; 25(5): 1793 - 1803.
[Abstract] [Full Text] [PDF]

D. van Dyk, I. S. Pretorius, and F. F. Bauer
Mss11p Is a Central Element of the Regulatory Network That Controls FLO11 Expression and Invasive Growth in Saccharomyces cerevisiae
Genetics, January 1, 2005; 169(1): 91 - 106.
[Abstract] [Full Text] [PDF]

P. J. Cullen, W. Sabbagh Jr., E. Graham, M. M. Irick, E. K. van Olden, C. Neal, J. Delrow, L. Bardwell, and G. F. Sprague Jr.
A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast
Genes & Dev., July 15, 2004; 18(14): 1695 - 1708.
[Abstract] [Full Text] [PDF]

M. B. Einarson, E. Cukierman, D. A. Compton, and E. A. Golemis
Human Enhancer of Invasion-Cluster, a Coiled-Coil Protein Required for Passage through Mitosis
Mol. Cell. Biol., May 1, 2004; 24(9): 3957 - 3971.
[Abstract] [Full Text] [PDF]

F. Li and S. P. Palecek
EAP1, a Candida albicans Gene Involved in Binding Human Epithelial Cells
Eukaryot. Cell, December 1, 2003; 2(6): 1266 - 1273.
[Abstract] [Full Text] [PDF]

Y. W. Jiang and C. M. Kang
Induction of S. cerevisiae Filamentous Differentiation by Slowed DNA Synthesis Involves Mec1, Rad53 and Swe1 Checkpoint Proteins
Mol. Biol. Cell, December 1, 2003; 14(12): 5116 - 5124.
[Abstract] [Full Text] [PDF]

A. Breitkreutz, L. Boucher, B.-J. Breitkreutz, M. Sultan, I. Jurisica, and M. Tyers
Phenotypic and Transcriptional Plasticity Directed by a Yeast Mitogen-Activated Protein Kinase Network
Genetics, November 1, 2003; 165(3): 997 - 1015.
[Abstract] [Full Text] [PDF]

K. A. Willis, K. E. Barbara, B. B. Menon, J. Moffat, B. Andrews, and G. M. Santangelo
The Global Transcriptional Activator of Saccharomyces cerevisiae, Gcr1p, Mediates the Response to Glucose by Stimulating Protein Synthesis and CLN-Dependent Cell Cycle Progression
Genetics, November 1, 2003; 165(3): 1017 - 1029.
[Abstract] [Full Text] [PDF]

G. H. Braus, O. Grundmann, S. Bruckner, and H.-U. Mosch
Amino Acid Starvation and Gcn4p Regulate Adhesive Growth and FLO11 Gene Expression in Saccharomyces cerevisiae
Mol. Biol. Cell, October 1, 2003; 14(10): 4272 - 4284.
[Abstract] [Full Text] [PDF]

A. Tanghe, P. Van Dijck, F. Dumortier, A. Teunissen, S. Hohmann, and J. M. Thevelein
Aquaporin Expression Correlates with Freeze Tolerance in Baker's Yeast, and Overexpression Improves Freeze Tolerance in Industrial Strains
Appl. Envir. Microbiol., December 1, 2002; 68(12): 5981 - 5989.
[Abstract] [Full Text] [PDF]

I. Mannazzu, E. Simonetti, P. Marinangeli, E. Guerra, M. Budroni, M. Thangavelu, and F. Clementi
SED1 Gene Length and Sequence Polymorphisms in Feral Strains of Saccharomyces cerevisiae
Appl. Envir. Microbiol., November 1, 2002; 68(11): 5437 - 5444.
[Abstract] [Full Text] [PDF]

T. Kohler, S. Wesche, N. Taheri, G. H. Braus, and H.-U. Mosch
Dual Role of the Saccharomyces cerevisiae TEA/ATTS Family Transcription Factor Tec1p in Regulation of Gene Expression and Cellular Development
Eukaryot. Cell, October 1, 2002; 1(5): 673 - 686.
[Abstract] [Full Text] [PDF]

S. Ito-Harashima, P. E. Hartzog, H. Sinha, and J. H. McCusker
The tRNA-Tyr Gene Family of Saccharomyces cerevisiae: Agents of Phenotypic Variation and Position Effects on Mutation Frequency
Genetics, August 1, 2002; 161(4): 1395 - 1410.
[Abstract] [Full Text] [PDF]

X. Pan and J. Heitman
Protein Kinase A Operates a Molecular Switch That Governs Yeast Pseudohyphal Differentiation
Mol. Cell. Biol., June 15, 2002; 22(12): 3981 - 3993.
[Abstract] [Full Text] [PDF]

S. P. Palecek, A. S. Parikh, and S. J. Kron
Sensing, signalling and integrating physical processes during Saccharomyces cerevisiae invasive and filamentous growth
Microbiology, April 1, 2002; 148(4): 893 - 907.
[Full Text] [PDF]

M. Shichiri, C. Hoshikawa, S. Nakamori, and H. Takagi
A Novel Acetyltransferase Found in Saccharomyces cerevisiaeSigma 1278b That Detoxifies a Proline Analogue, Azetidine-2-carboxylic Acid
J. Biol. Chem., November 2, 2001; 276(45): 41998 - 42002.
[Abstract] [Full Text] [PDF]

R. D. Emes and C. P. Ponting
A new sequence motif linking lissencephaly, Treacher Collins and oral-facial-digital type 1 syndromes, microtubule dynamics and cell migration
Hum. Mol. Genet., November 1, 2001; 10(24): 2813 - 2820.
[Abstract] [Full Text] [PDF]

A. L. Goldstein and J. H. McCusker
Development of Saccharomyces cerevisiae as a Model Pathogen: A System for the Genetic Identification of Gene Products Required for Survival in the Mammalian Host Environment
Genetics, October 1, 2001; 159(2): 499 - 513.
[Abstract] [Full Text] [PDF]

R. Scherz, V. Shinder, and D. Engelberg
Anatomical Analysis of Saccharomyces cerevisiae Stalk-Like Structures Reveals Spatial Organization and Cell Specialization
J. Bacteriol., September 15, 2001; 183(18): 5402 - 5413.
[Abstract] [Full Text] [PDF]

C. Miled, C. Mann, and G. Faye
Xbp1-Mediated Repression of CLB Gene Expression Contributes to the Modifications of Yeast Cell Morphology and Cell Cycle Seen during Nitrogen-Limited Growth
Mol. Cell. Biol., June 1, 2001; 21(11): 3714 - 3724.
[Abstract] [Full Text]

R. La Valle and C. Wittenberg
A Role for the Swe1 Checkpoint Kinase During Filamentous Growth of Saccharomyces cerevisiae
Genetics, June 1, 2001; 158(2): 549 - 562.
[Abstract] [Full Text] [PDF]

S. D. Johnston, S. Enomoto, L. Schneper, M. C. McClellan, F. Twu, N. D. Montgomery, S. A. Haney, J. R. Broach, and J. Berman
CAC3 (MSI1) Suppression of RAS2G19V Is Independent of Chromatin Assembly Factor I and Mediated by NPR1
Mol. Cell. Biol., March 1, 2001; 21(5): 1784 - 1794.
[Abstract] [Full Text]

C. M. Asleson, E. S. Bensen, C. A. Gale, A.-S. Melms, C. Kurischko, and J. Berman
Candida albicans INT1-Induced Filamentation in Saccharomyces cerevisiae Depends on Sla2p
Mol. Cell. Biol., February 15, 2001; 21(4): 1272 - 1284.
[Abstract] [Full Text]

T. B. Reynolds and G. R. Fink
Bakers' Yeast, a Model for Fungal Biofilm Formation
Science, February 2, 2001; 291(5505): 878 - 881.
[Abstract] [Full Text] [PDF]

J. M. Carbrey, M. Bonhivers, J. D. Boeke, and P. Agre
Aquaporins in Saccharomyces: Characterization of a second functional water channel protein
PNAS, January 30, 2001; 98(3): 1000 - 1005.
[Abstract] [Full Text] [PDF]

K. B. Lengeler, R. C. Davidson, C. D'souza, T. Harashima, W.-C. Shen, P. Wang, X. Pan, M. Waugh, and J. Heitman
Signal Transduction Cascades Regulating Fungal Development and Virulence
Microbiol. Mol. Biol. Rev., December 1, 2000; 64(4): 746 - 785.
[Abstract] [Full Text] [PDF]

J. Chen, S. Zhou, Q. Wang, X. Chen, T. Pan, and H. Liu
Crk1, a Novel Cdc2-Related Protein Kinase, Is Required for Hyphal Development and Virulence in Candida albicans
Mol. Cell. Biol., December 1, 2000; 20(23): 8696 - 8708.
[Abstract] [Full Text]

J. Conner and Z. Liu
LEUNIG, a putative transcriptional corepressor that regulates AGAMOUS expression during flower development
PNAS, October 26, 2000; (2000) 230352397.
[Abstract] [Full Text]

H. Takagi, M. Shichiri, M. Takemura, M. Mohri, and S. Nakamori
Saccharomyces cerevisiae Sigma 1278b Has Novel Genes of the N-Acetyltransferase Gene Superfamily Required for L-Proline Analogue Resistance
J. Bacteriol., August 1, 2000; 182(15): 4249 - 4256.
[Abstract] [Full Text]

A. Morillon, M. Springer, and P. Lesage
Activation of the Kss1 Invasive-Filamentous Growth Pathway Induces Ty1 Transcription and Retrotransposition in Saccharomyces cerevisiae
Mol. Cell. Biol., August 1, 2000; 20(15): 5766 - 5776.
[Abstract] [Full Text]

P. C. Hollenhorst, M. E. Bose, M. R. Mielke, U. Müller, and C. A. Fox
Forkhead Genes in Transcriptional Silencing, Cell Morphology and the Cell Cycle: Overlapping and Distinct Functions for FKH1 and FKH2 in Saccharomyces cerevisiae
Genetics, April 1, 2000; 154(4): 1533 - 1548.
[Abstract] [Full Text]

C. J. Roberts, B. Nelson, M. J. Marton, R. Stoughton, M. R. Meyer, H. A. Bennett, Y. D. He, H. Dai, W. L. Walker, T. R. Hughes, et al.
Signaling and Circuitry of Multiple MAPK Pathways Revealed by a Matrix of Global Gene Expression Profiles
Science, February 4, 2000; 287(5454): 873 - 880.
[Abstract] [Full Text]

M. C. Lorenz, N. S. Cutler, and J. Heitman
Characterization of Alcohol-induced Filamentous Growth in Saccharomyces cerevisiae
Mol. Biol. Cell, January 1, 2000; 11(1): 183 - 199.
[Abstract] [Full Text]

J. D. J. Loeb, T. A. Kerentseva, T. Pan, M. Sepulveda-Becerra, and H. Liu
Saccharomyces cerevisiae G1 Cyclins Are Differentially Involved in Invasive and Pseudohyphal Growth Independent of the Filamentation Mitogen-Activated Protein Kinase Pathway
Genetics, December 1, 1999; 153(4): 1535 - 1546.
[Abstract] [Full Text]

A. Stanhill, N. Schick, and D. Engelberg
The Yeast Ras/Cyclic AMP Pathway Induces Invasive Growth by Suppressing the Cellular Stress Response
Mol. Cell. Biol., November 1, 1999; 19(11): 7529 - 7538.
[Abstract] [Full Text] [PDF]

M. Gagiano, D. Van Dyk, F. F. Bauer, M. G. Lambrechts, and I. S. Pretorius
Divergent Regulation of the Evolutionarily Closely Related Promoters of the Saccharomyces cerevisiae STA2 and MUC1 Genes
J. Bacteriol., October 15, 1999; 181(20): 6497 - 6508.
[Abstract] [Full Text]

H. Klasson, G. R. Fink, and P. O. Ljungdahl
Ssy1p and Ptr3p Are Plasma Membrane Components of a Yeast System That Senses Extracellular Amino Acids
Mol. Cell. Biol., August 1, 1999; 19(8): 5405 - 5416.
[Abstract] [Full Text] [PDF]

X. Pan and J. Heitman
Cyclic AMP-Dependent Protein Kinase Regulates Pseudohyphal Differentiation in Saccharomyces cerevisiae
Mol. Cell. Biol., July 1, 1999; 19(7): 4874 - 4887.
[Abstract] [Full Text] [PDF]

P. A. Kirchman, S. Kim, C.-Y. Lai, and S. M. Jazwinski
Interorganelle Signaling Is a Determinant of Longevity in Saccharomyces cerevisiae
Genetics, May 1, 1999; 152(1): 179 - 190.
[Abstract] [Full Text]

J. Jantti, J. Lahdenranta, V. M. Olkkonen, H. Soderlund, and S. Keranen
SEM1, a homologue of the split hand/split foot malformation candidate gene Dss1, regulates exocytosis and pseudohyphal differentiation in yeast
PNAS, February 2, 1999; 96(3): 909 - 914.
[Abstract] [Full Text] [PDF]

N. P. Edgington, M. J. Blacketer, T. A. Bierwagen, and A. M. Myers
Control of Saccharomyces cerevisiae Filamentous Growth by Cyclin-Dependent Kinase Cdc28
Mol. Cell. Biol., February 1, 1999; 19(2): 1369 - 1380.
[Abstract] [Full Text] [PDF]

L. Bardwell, J. G. Cook, J. X. Zhu-Shimoni, D. Voora, and J. Thorner
Differential regulation of transcription: Repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins
PNAS, December 22, 1998; 95(26): 15400 - 15405.
[Abstract] [Full Text] [PDF]

O. Kobayashi, N. Hayashi, R. Kuroki, and H. Sone
Region of Flo1 Proteins Responsible for Sugar Recognition
J. Bacteriol., December 15, 1998; 180(24): 6503 - 6510.
[Abstract] [Full Text]

M. C. Gustin, J. Albertyn, M. Alexander, and K. Davenport
MAP Kinase Pathways in the Yeast Saccharomyces cerevisiae
Microbiol. Mol. Biol. Rev., December 1, 1998; 62(4): 1264 - 1300.
[Abstract] [Full Text] [PDF]

M. Bonhivers, J. M. Carbrey, S. J. Gould, and P. Agre
Aquaporins in Saccharomyces. GENETIC AND FUNCTIONAL DISTINCTIONS BETWEEN LABORATORY AND WILD-TYPE STRAINS
J. Biol. Chem., October 16, 1998; 273(42): 27565 - 27572.
[Abstract] [Full Text] [PDF]

B. M. Cali, T. C. Doyle, D. Botstein, and G. R. Fink
Multiple Functions for Actin during Filamentous Growth of Saccharomyces cerevisiae
Mol. Biol. Cell, July 1, 1998; 9(7): 1873 - 1889.
[Abstract] [Full Text]

T Roemer, L Vallier, Y. Sheu, and M Snyder
The Spa2-related protein, Sph1p, is important for polarized growth in yeast
J. Cell Sci., January 2, 1998; 111(4): 479 - 494.
[Abstract] [PDF]

W.-S. Lo and A. M. Dranginis
The Cell Surface Flocculin Flo11 Is Required for Pseudohyphae Formation and Invasion by Saccharomyces cerevisiae
Mol. Biol. Cell, January 1, 1998; 9(1): 161 - 171.
[Abstract] [Full Text]

J. Conner and Z. Liu
LEUNIG, a putative transcriptional corepressor that regulates AGAMOUS expression during flower development
PNAS, November 7, 2000; 97(23): 12902 - 12907.
[Abstract] [Full Text] [PDF]

				J. Dodgson, H. Avula, K.-L. Hoe, D.-U. Kim, H.-O. Park, J. Hayles, and J. Armstrong Functional Genomics of Adhesion, Invasion, and Mycelial Formation in Schizosaccharomyces pombe Eukaryot. Cell, August 1, 2009; 8(8): 1298 - 1306. [Abstract] [Full Text] [PDF]

				X. Mao, X. Nie, F. Cao, and J. Chen Functional analysis of ScSwi1 and CaSwi1 in invasive and pseudohyphal growth of Saccharomyces cerevisiae Acta Biochim Biophys Sin, July 1, 2009; 41(7): 594 - 602. [Abstract] [Full Text] [PDF]

				L. A. Strawn, C. A. Lin, E. M.H. Tank, M. M. Osman, S. A. Simpson, and H. L. True Mutants of the Paf1 Complex Alter Phenotypic Expression of the Yeast Prion [PSI+] Mol. Biol. Cell, April 15, 2009; 20(8): 2229 - 2241. [Abstract] [Full Text] [PDF]

				P. Govender, J. L. Domingo, M. C. Bester, I. S. Pretorius, and F. F. Bauer Controlled Expression of the Dominant Flocculation Genes FLO1, FLO5, and FLO11 in Saccharomyces cerevisiae Appl. Envir. Microbiol., October 1, 2008; 74(19): 6041 - 6052. [Abstract] [Full Text] [PDF]

				O. A. Zill and J. Rine Interspecies variation reveals a conserved repressor of {alpha}-specific genes in Saccharomyces yeasts Genes & Dev., June 15, 2008; 22(12): 1704 - 1716. [Abstract] [Full Text] [PDF]

				F. Li and S. P. Palecek Distinct domains of the Candida albicans adhesin Eap1p mediate cell-cell and cell-substrate interactions Microbiology, April 1, 2008; 154(4): 1193 - 1203. [Abstract] [Full Text] [PDF]

				L. M. Douglas, L. Li, Y. Yang, and A. M. Dranginis Expression and Characterization of the Flocculin Flo11/Muc1, a Saccharomyces cerevisiae Mannoprotein with Homotypic Properties of Adhesion Eukaryot. Cell, December 1, 2007; 6(12): 2214 - 2221. [Abstract] [Full Text] [PDF]

				Y. Li, C. Su, X. Mao, F. Cao, and J. Chen Roles of Candida albicans Sfl1 in Hyphal Development Eukaryot. Cell, November 1, 2007; 6(11): 2112 - 2121. [Abstract] [Full Text] [PDF]

				A. Gacser, F. Stehr, C. Kroger, L. Kredics, W. Schafer, and J. D. Nosanchuk Lipase 8 Affects the Pathogenesis of Candida albicans Infect. Immun., October 1, 2007; 75(10): 4710 - 4718. [Abstract] [Full Text] [PDF]

				J. Ma, R. Jin, X. Jia, C. J. Dobry, L. Wang, F. Reggiori, J. Zhu, and A. Kumar An Interrelationship Between Autophagy and Filamentous Growth in Budding Yeast Genetics, September 1, 2007; 177(1): 205 - 214. [Abstract] [Full Text] [PDF]

				W. V. Gilbert, K. Zhou, T. K. Butler, and J. A. Doudna Cap-Independent Translation Is Required for Starvation-Induced Differentiation in Yeast Science, August 31, 2007; 317(5842): 1224 - 1227. [Abstract] [Full Text] [PDF]

				W. Wei, J. H. McCusker, R. W. Hyman, T. Jones, Y. Ning, Z. Cao, Z. Gu, D. Bruno, M. Miranda, M. Nguyen, et al. Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789 PNAS, July 31, 2007; 104(31): 12825 - 12830. [Abstract] [Full Text] [PDF]

				Y.-U. Park, H. Hur, M. Ka, and J. Kim Identification of Translational Regulation Target Genes during Filamentous Growth in Saccharomyces cerevisiae: Regulatory Role of Caf20 and Dhh1 Eukaryot. Cell, December 1, 2006; 5(12): 2120 - 2127. [Abstract] [Full Text] [PDF]

				T. K. Ezov, E. Boger-Nadjar, Z. Frenkel, I. Katsperovski, S. Kemeny, E. Nevo, A. Korol, and Y. Kashi Molecular-Genetic Biodiversity in a Natural Population of the Yeast Saccharomyces cerevisiae From "Evolution Canyon": Microsatellite Polymorphism, Ploidy and Controversial Sexual Status Genetics, November 1, 2006; 174(3): 1455 - 1468. [Abstract] [Full Text] [PDF]

				V. Voynov, K. J. Verstrepen, A. Jansen, V. M. Runner, S. Buratowski, and G. R. Fink Genes with internal repeats require the THO complex for transcription PNAS, September 26, 2006; 103(39): 14423 - 14428. [Abstract] [Full Text] [PDF]

				J. Ronald, H. Tang, and R. B. Brem Genomewide Evolutionary Rates in Laboratory and Wild Yeast Genetics, September 1, 2006; 174(1): 541 - 544. [Abstract] [Full Text] [PDF]

				G. Huang, H. Wang, S. Chou, X. Nie, J. Chen, and H. Liu From the Cover: Bistable expression of WOR1, a master regulator of white-opaque switching in Candida albicans PNAS, August 22, 2006; 103(34): 12813 - 12818. [Abstract] [Full Text] [PDF]

				M. J. Brauer, C. M. Christianson, D. A. Pai, and M. J. Dunham Mapping Novel Traits by Array-Assisted Bulk Segregant Analysis in Saccharomyces cerevisiae Genetics, July 1, 2006; 173(3): 1813 - 1816. [Abstract] [Full Text] [PDF]

				A. R. Borneman, J. A. Leigh-Bell, H. Yu, P. Bertone, M. Gerstein, and M. Snyder Target hub proteins serve as master regulators of development in yeast Genes & Dev., February 15, 2006; 20(4): 435 - 448. [Abstract] [Full Text] [PDF]

				F. Cao, S. Lane, P. P. Raniga, Y. Lu, Z. Zhou, K. Ramon, J. Chen, and H. Liu The Flo8 Transcription Factor Is Essential for Hyphal Development and Virulence in Candida albicans Mol. Biol. Cell, January 1, 2006; 17(1): 295 - 307. [Abstract] [Full Text] [PDF]

				A. Trott, L. Shaner, and K. A. Morano The Molecular Chaperone Sse1 and the Growth Control Protein Kinase Sch9 Collaborate to Regulate Protein Kinase A Activity in Saccharomyces cerevisiae Genetics, July 1, 2005; 170(3): 1009 - 1021. [Abstract] [Full Text] [PDF]

				S. Zara, A. T. Bakalinsky, G. Zara, G. Pirino, M. A. Demontis, and M. Budroni FLO11-Based Model for Air-Liquid Interfacial Biofilm Formation by Saccharomyces cerevisiae Appl. Envir. Microbiol., June 1, 2005; 71(6): 2934 - 2939. [Abstract] [Full Text] [PDF]

				L. J. Flatauer, S. F. Zadeh, and L. Bardwell Mitogen-Activated Protein Kinases with Distinct Requirements for Ste5 Scaffolding Influence Signaling Specificity in Saccharomyces cerevisiae Mol. Cell. Biol., March 1, 2005; 25(5): 1793 - 1803. [Abstract] [Full Text] [PDF]

				D. van Dyk, I. S. Pretorius, and F. F. Bauer Mss11p Is a Central Element of the Regulatory Network That Controls FLO11 Expression and Invasive Growth in Saccharomyces cerevisiae Genetics, January 1, 2005; 169(1): 91 - 106. [Abstract] [Full Text] [PDF]

				P. J. Cullen, W. Sabbagh Jr., E. Graham, M. M. Irick, E. K. van Olden, C. Neal, J. Delrow, L. Bardwell, and G. F. Sprague Jr. A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast Genes & Dev., July 15, 2004; 18(14): 1695 - 1708. [Abstract] [Full Text] [PDF]

				M. B. Einarson, E. Cukierman, D. A. Compton, and E. A. Golemis Human Enhancer of Invasion-Cluster, a Coiled-Coil Protein Required for Passage through Mitosis Mol. Cell. Biol., May 1, 2004; 24(9): 3957 - 3971. [Abstract] [Full Text] [PDF]

				F. Li and S. P. Palecek EAP1, a Candida albicans Gene Involved in Binding Human Epithelial Cells Eukaryot. Cell, December 1, 2003; 2(6): 1266 - 1273. [Abstract] [Full Text] [PDF]

				Y. W. Jiang and C. M. Kang Induction of S. cerevisiae Filamentous Differentiation by Slowed DNA Synthesis Involves Mec1, Rad53 and Swe1 Checkpoint Proteins Mol. Biol. Cell, December 1, 2003; 14(12): 5116 - 5124. [Abstract] [Full Text] [PDF]

				A. Breitkreutz, L. Boucher, B.-J. Breitkreutz, M. Sultan, I. Jurisica, and M. Tyers Phenotypic and Transcriptional Plasticity Directed by a Yeast Mitogen-Activated Protein Kinase Network Genetics, November 1, 2003; 165(3): 997 - 1015. [Abstract] [Full Text] [PDF]

				K. A. Willis, K. E. Barbara, B. B. Menon, J. Moffat, B. Andrews, and G. M. Santangelo The Global Transcriptional Activator of Saccharomyces cerevisiae, Gcr1p, Mediates the Response to Glucose by Stimulating Protein Synthesis and CLN-Dependent Cell Cycle Progression Genetics, November 1, 2003; 165(3): 1017 - 1029. [Abstract] [Full Text] [PDF]