- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Uimari, P.
- Articles by Hoeschele, I.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Uimari, P.
- Articles by Hoeschele, I.
Genetics, Vol 143, 1831-1842, Copyright © 1996
INVESTIGATIONS |
The Use of Multiple Markers in a Bayesian Method for Mapping Quantitative Trait Loci
P. Uimari, G. Thaller and I. Hoeschele
Department of Animal and Range Sciences, Montana State University, Bozeman, MT 59717
Information on multiple linked genetic markers was used in a Bayesian method for the statistical mapping of quantitative trait loci (QTL). Bayesian parameter estimation and hypothesis testing were implemented via Markov chain Monte Carlo algorithms. Variables sampled were the augmented data (marker-QTL genotypes, polygenic effects), an indicator variable for linkage or nonlinkage, and the parameters. The parameter vector included allele frequencies at the markers and the QTL, map distances of the markers and the QTL, QTL substitution effect, and polygenic and residual variances. The criterion for QTL detection was the marginal posterior probability of a QTL being located on the chromosome carrying the markers. The method was evaluated empirically by analyzing simulated granddaughter designs consisting of 2000 sons, 20 related sires, and their ancestors.
This article has been cited by other articles:
 |
|
 |
|
  J. B. C. H. M. van Kaam, M. C. A. M. Bink, D. O. Maizon, J. A. M. van Arendonk, and R. L. Quaas Bayesian reanalysis of a quantitative trait locus accounting for multiple environments by scaling in broilers J Anim Sci, August 1, 2006; 84(8): 2009 - 2021. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Yi, S. Xu, and D. B. Allison Bayesian Model Choice and Search Strategies for Mapping Interacting Quantitative Trait Loci Genetics, October 1, 2003; 165(2): 867 - 883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. de Koning, R. Pong-Wong, L. Varona, G. J. Evans, E. Giuffra, A. Sanchez, G. Plastow, J. L. Noguera, L. Andersson, and C. S. Haley Full pedigree quantitative trait locus analysis in commercial pigs using variance components J Anim Sci, September 1, 2003; 81(9): 2155 - 2163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Wu, C.-X. Ma, and G. Casella Joint Linkage and Linkage Disequilibrium Mapping of Quantitative Trait Loci in Natural Populations Genetics, February 1, 2002; 160(2): 779 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Yi and S. Xu Bayesian Mapping of Quantitative Trait Loci for Complex Binary Traits Genetics, July 1, 2000; 155(3): 1391 - 1403. [Abstract] [Full Text]
|
|
|
|
|
|
M. C. A. M. Bink and J. A. M. Van Arendonk Detection of Quantitative Trait Loci in Outbred Populations With Incomplete Marker Data Genetics, January 1, 1999; 151(1): 409 - 420. [Abstract] [Full Text]
|
|
|
|
|
|
J. Shoemaker, I. Painter, and B. S. Weir A Bayesian Characterization of Hardy-Weinberg Disequilibrium Genetics, August 1, 1998; 149(4): 2079 - 2088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Sillanpaa and E. Arjas Bayesian Mapping of Multiple Quantitative Trait Loci From Incomplete Inbred Line Cross Data Genetics, March 1, 1998; 148(3): 1373 - 1388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Mixture Model Approach to the Mapping of Quantitative Trait Loci in Complex Populations With an Application to Multiple Cattle Families Genetics, January 1, 1998; 148(1): 391 - 400.
|
|