A Genetic Analysis of pannier, a Gene Necessary for Viability of Dorsal Tissues and Bristle Positioning in Drosophila

INVESTIGATIONS

A Genetic Analysis of pannier, a Gene Necessary for Viability of Dorsal Tissues and Bristle Positioning in Drosophila

P. Heitzler, M. Haenlin, P. Ramain, M. Calleja and P. Simpson
Institut de Genetique et de Biologie Moleculaire et Cellulaire, 67404 Illkirch cedex, France

A genetic and phenotypic analysis of the gene pannier is described. Animals mutant for strong alleles die as embryos in which the cells of the amnioserosa are prematurely lost. This leads to a dorsal cuticular hole. The dorsal-most cells of the imagos are also affected: viable mutants exhibit a cleft along the dorsal midline. pannier mRNA accumulates specifically in the dorsal-most regions of the embryo and the imaginal discs. Viable mutants and mutant combinations also affect the thoracic and head bristle patterns in a complex fashion. Only those bristles within the area of expression of pannier are affected. A large number of alleles have been studied and reveal that pannier may have opposing effects on the expression of achaete and scute leading to a loss or a gain of bristles.

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				H. A. Dworak, M. A. Charles, L. B. Pellerano, and H. Sink Characterization of Drosophila hibris, a gene related to human nephrin Development, November 1, 2001; 128(21): 4265 - 4276. [Abstract] [Full Text] [PDF]

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				R Dorfman and B. Shilo Biphasic activation of the BMP pathway patterns the Drosophila embryonic dorsal region Development, January 3, 2001; 128(6): 965 - 972. [Abstract] [PDF]

				J Culi, E Martin-Blanco, and J Modolell The EGF receptor and N signalling pathways act antagonistically in Drosophila mesothorax bristle patterning Development, January 1, 2001; 128(2): 299 - 308. [Abstract] [PDF]

				Y. Takatsu, M. Nakamura, M. Stapleton, M. C. Danos, K. Matsumoto, M. B. O'Connor, H. Shibuya, and N. Ueno TAK1 Participates in c-Jun N-Terminal Kinase Signaling during Drosophila Development Mol. Cell. Biol., May 1, 2000; 20(9): 3015 - 3026. [Abstract] [Full Text]

				R. Fernandez, F. Takahashi, Z. Liu, R. Steward, D. Stein, and E. R. Stanley The Drosophila Shark tyrosine kinase is required for embryonic dorsal closure Genes & Dev., March 1, 2000; 14(5): 604 - 614. [Abstract] [Full Text]

				S Brown and J Castelli-Gair Hombria Drosophila grain encodes a GATA transcription factor required for cell rearrangement during morphogenesis Development, January 11, 2000; 127(22): 4867 - 4876. [Abstract] [PDF]

				M Calleja, H Herranz, C Estella, J Casal, P Lawrence, P Simpson, and G Morata Generation of medial and lateral dorsal body domains by the pannier gene of Drosophila Development, January 9, 2000; 127(18): 3971 - 3980. [Abstract] [PDF]

				H. Ashe, M Mannervik, and M Levine Dpp signaling thresholds in the dorsal ectoderm of the Drosophila embryo Development, January 8, 2000; 127(15): 3305 - 3312. [Abstract] [PDF]

				C Maurel-Zaffran and J. Treisman pannier acts upstream of wingless to direct dorsal eye disc development in Drosophila Development, January 3, 2000; 127(5): 1007 - 1016. [Abstract] [PDF]

				S Zaffran and M Frasch Barbu: an E(spl) m4/m(alpha)-related gene that antagonizes Notch signaling and is required for the establishment of ommatidial polarity Development, January 3, 2000; 127(5): 1115 - 1130. [Abstract] [PDF]

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				J Zeitlinger and D Bohmann Thorax closure in Drosophila: involvement of Fos and the JNK pathway Development, January 9, 1999; 126(17): 3947 - 3956. [Abstract] [PDF]