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Genetics, Vol 143, 1175-1180, Copyright © 1996
INVESTIGATIONS |
Mutants With Altered Sensitivity to a Calmodulin Antagonist Affect the Circadian Clock in Neurospora crassa
S. Suzuki, S. Katagiri and H. Nakashima
Faculty of Science, Department of Biology, Okayama University, Okayama 700, Japan
Two newly isolated mutant strains of Neurospora crassa, cpz-1 and cpz-2, were hypersensitive to chlorpromazine with respect to mycelial growth but responded differently to the drug with respect to the circadian conidiation rhythm. In the wild type, chlorpromazine caused shortening of the period length of the conidiation rhythm. Pulse treatment with the drug shifted the phase and inhibited light-induced phase shifting in Neurospora. By contrast to the wild type, the cpz-2 strain was resistant to these inhibitory effects of chlorpromazine. Inhibition of cpz-2 function by chlorpromazine affected three different parameters of circadian conidiation rhythm, namely, period length, phase and light-induced phase shifting. These results indicate that the cpz-2 gene must be involved in or related closely to the clock mechanism of Neurospora. By contrast, the cpz-1 strain was hypersensitive to chlorpromazine with respect to the circadian conidiation rhythm.
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  Y. Yang, P. Cheng, G. Zhi, and Y. Liu Identification of a Calcium/Calmodulin-dependent Protein Kinase That Phosphorylates the Neurospora Circadian Clock Protein FREQUENCY J. Biol. Chem., October 26, 2001; 276(44): 41064 - 41072. [Abstract] [Full Text] [PDF]
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