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Genetics, Vol 143, 237-247, Copyright © 1996
INVESTIGATIONS |
The Caenorhabditis elegans sel-1 Gene, a Negative Regulator of lin-12 and glp-1, Encodes a Predicted Extracellular Protein
B. Grant and I. Greenwald
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 and Department of Biochemistry and Molecular Biophysics, Columbia University, College of Physicians and Surgeons, New York, New York 10032
The Caenorhabditis elegans lin-12 and glp-1 genes encode members of the LIN-12/NOTCH family of receptors. The sel-1 gene was identified as an extragenic suppressor of a lin-12 hypomorphic mutant. We show in this report that the sel-1 null phenotype is wild type, except for an apparent elevation in lin-12 and glp-1 activity in sensitized genetic backgrounds, and that this genetic interaction seems to be lin-12 and glp-1 specific. We also find that sel-1 encodes a predicted extracellular protein, with a domain sharing sequence similarity to predicted proteins from humans and yeast. SEL-1 may interact with the LIN-12 and GLP-1 receptors and/or their respective ligands to down-regulate signaling.
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