- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Kolman, C. J.
- Articles by Bermingham, E.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Kolman, C. J.
- Articles by Bermingham, E.
Genetics, Vol 142, 1321-1334, Copyright © 1996
INVESTIGATIONS |
Mitochondrial DNA Analysis of Mongolian Populations and Implications for the Origin of New World Founders
C. J. Kolman, N. Sambuughin and E. Bermingham
Smithsonian Tropical Research Institute, Apartado 2072, Balboa, Panama
High levels of mitochondrial DNA (mtDNA) diversity were determined for Mongolian populations, represented by the Mongol-speaking Khalkha and Dariganga. Although 103 samples were collected across Mongolia, low levels of genetic substructuring were detected, reflecting the nomadic lifestyle and relatively recent ethnic differentiation of Mongolian populations. mtDNA control region I sequence and seven additional mtDNA polymorphisms were assayed to allow extensive comparison with previous human population studies. Based on a comparative analysis, we propose that indigenous populations in east Central Asia represent the closest genetic link between Old and New World populations. Utilizing restriction/deletion polymorphisms, Mongolian populations were found to carry all four New World founding haplogroups as defined by WALLACE and coworkers. The ubiquitous presence of the four New World haplogroups in the Americas but narrow distribution across Asia weakens support for GREENBERG and coworkers' theory of New World colonization via three independent migrations. The statistical and geographic scarcity of New World haplogroups in Asia makes it improbable that the same four haplotypes would be drawn from one geographic region three independent times. Instead, it is likely that founder effects manifest throughout Asia and the Americas are responsible for differences in mtDNA haplotype frequencies observed in these regions.
This article has been cited by other articles:
 |
|
 |
|
  M. G. B. Blum and N. A. Rosenberg Estimating the Number of Ancestral Lineages Using a Maximum-Likelihood Method Based on Rejection Sampling Genetics, July 1, 2007; 176(3): 1741 - 1757. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Hill, P. Soares, M. Mormina, V. Macaulay, W. Meehan, J. Blackburn, D. Clarke, J. M. Raja, P. Ismail, D. Bulbeck, et al. Phylogeography and Ethnogenesis of Aboriginal Southeast Asians Mol. Biol. Evol., December 1, 2006; 23(12): 2480 - 2491. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tanaka, V. M. Cabrera, A. M. Gonzalez, J. M. Larruga, T. Takeyasu, N. Fuku, L.-J. Guo, R. Hirose, Y. Fujita, M. Kurata, et al. Mitochondrial Genome Variation in Eastern Asia and the Peopling of Japan Genome Res., October 1, 2004; 14(10a): 1832 - 1850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. A. ZAKHAROV, M. V. DERENKO, B. A. MALIARCHUK, I. K. DAMBUEVA, C. M. DORZHU, and S. Y. RYCHKOV Mitochondrial DNA Variation in the Aboriginal Populations of the Altai-Baikal Region: Implications for the Genetic History of North Asia and America Ann. N.Y. Acad. Sci., April 1, 2004; 1011(1): 21 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Zegura, T. M. Karafet, L. A. Zhivotovsky, and M. F. Hammer High-Resolution SNPs and Microsatellite Haplotypes Point to a Single, Recent Entry of Native American Y Chromosomes into the Americas Mol. Biol. Evol., January 1, 2004; 21(1): 164 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kivisild, H.-V. Tolk, J. Parik, Y. Wang, S. S. Papiha, H.-J. Bandelt, and R. Villems The Emerging Limbs and Twigs of the East Asian mtDNA Tree Mol. Biol. Evol., October 1, 2002; 19(10): 1737 - 1751. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Bonatto and F. M. Salzano A single and early migration for the peopling of the Americas supported by mitochondrial DNA sequence data PNAS, March 4, 1997; 94(5): 1866 - 1871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bamshad, T. Kivisild, W. S. Watkins, M. E. Dixon, C. E. Ricker, B. B. Rao, J. M. Naidu, B.V. R. Prasad, P. G. Reddy, A. Rasanayagam, et al. Genetic Evidence on the Origins of Indian Caste Populations Genome Res., June 1, 2001; 11(6): 994 - 1004. [Abstract] [Full Text] [PDF]
|
|