Quantitative Trait Loci for Murine Growth

INVESTIGATIONS

Quantitative Trait Loci for Murine Growth

J. M. Cheverud, E. J. Routman, FAM. Duarte, B. van-Swinderen, K. Cothran and C. Perel
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110

Body size is an archetypal quantitative trait with variation due to the segregation of many gene loci, each of relatively minor effect, and the environment. We examine the effects of quantitative trait loci (QTLs) on age-specific body weights and growth in the F(2) intercross of the LG/J and SM/J strains of inbred mice. Weekly weights (1-10 wk) and 75 microsatellite genotypes were obtained for 535 mice. Interval mapping was used to locate and measure the genotypic effects of QTLs on body weight and growth. QTL effects were detected on 16 of the 19 autosomes with several chromosomes carrying more than one QTL. The number of QTLs for age-specific weights varied from seven at 1 week to 17 at 10 wk. The QTLs were each of relatively minor, subequal effect. QTLs affecting early and late growth were generally distinct, mapping to different chromosomal locations indicating separate genetic and physiological systems for early and later murine growth.

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				J. P. Jarvis, J. Kenney-Hunt, T. H. Ehrich, L. S. Pletscher, C. F. Semenkovich, and J. M. Cheverud Maternal genotype affects adult offspring lipid, obesity, and diabetes phenotypes in LGXSM recombinant inbred strains J. Lipid Res., August 1, 2005; 46(8): 1692 - 1702. [Abstract] [Full Text] [PDF]

				T. H. Ehrich, T. Hrbek, J. P. Kenney-Hunt, L. S. Pletscher, B. Wang, C. F. Semenkovich, and J. M. Cheverud Fine-Mapping Gene-by-Diet Interactions on Chromosome 13 in a LG/J x SM/J Murine Model of Obesity Diabetes, June 1, 2005; 54(6): 1863 - 1872. [Abstract] [Full Text] [PDF]

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				J. M. Cheverud, T. H. Ehrich, T. Hrbek, J. P. Kenney, L. S. Pletscher, and C. F. Semenkovich Quantitative Trait Loci for Obesity- and Diabetes-Related Traits and Their Dietary Responses to High-Fat Feeding in LGXSM Recombinant Inbred Mouse Strains Diabetes, December 1, 2004; 53(12): 3328 - 3336. [Abstract] [Full Text] [PDF]

				R. Wu, Z. Wang, W. Zhao, and J. M. Cheverud A Mechanistic Model for Genetic Machinery of Ontogenetic Growth Genetics, December 1, 2004; 168(4): 2383 - 2394. [Abstract] [Full Text] [PDF]

				W. Zhao, J. Zhu, M. Gallo-Meagher, and R. Wu A Unified Statistical Model for Functional Mapping of Environment-Dependent Genetic Expression and Genotype x Environment Interactions for Ontogenetic Development Genetics, November 1, 2004; 168(3): 1751 - 1762. [Abstract] [Full Text] [PDF]

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				J. M. Cheverud, T. H. Ehrich, J. P. Kenney, L. S. Pletscher, and C. F. Semenkovich Genetic Evidence for Discordance Between Obesity- and Diabetes-Related Traits in the LGXSM Recombinant Inbred Mouse Strains Diabetes, October 1, 2004; 53(10): 2700 - 2708. [Abstract] [Full Text] [PDF]

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