Centromere-Linkage Analysis and Consolidation of the Zebrafish Genetic Map

INVESTIGATIONS

Centromere-Linkage Analysis and Consolidation of the Zebrafish Genetic Map

S. L. Johnson, M. A. Gates, M. Johnson, W. S. Talbot, S. Horne, K. Baik, S. Rude, J. R. Wong and J. H. Postlethwait
Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403

The ease of isolating mutations in zebrafish will contribute to an understanding of a variety of processes common to all vertebrates. To facilitate genetic analysis of such mutations, we have identified DNA polymorphisms closely linked to each of the 25 centromeres of zebrafish, placed centromeres on the linkage map, increased the number of mapped PCR-based markers to 652, and consolidated the number of linkage groups to the number of chromosomes. This work makes possible centromere-linkage analysis, a novel, rapid method to assign mutations to a specific linkage group using half-tetrads.

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				R. O. Karlstrom, O. V. Tyurina, A. Kawakami, N. Nishioka, W. S. Talbot, H. Sasaki, and A. F. Schier Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development Development, April 15, 2003; 130(8): 1549 - 1564. [Abstract] [Full Text] [PDF]

				K. D. Poss, A. Nechiporuk, A. M. Hillam, S. L. Johnson, and M. T. Keating Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration Development, March 13, 2003; 129(22): 5141 - 5149. [Abstract] [Full Text] [PDF]

				J. F. Rawls, M. R. Frieda, A. R. McAdow, J. P. Gross, C. M. Clayton, C. K. Heyen, and S. L. Johnson Coupled Mutagenesis Screens and Genetic Mapping in Zebrafish Genetics, March 1, 2003; 163(3): 997 - 1009. [Abstract] [Full Text] [PDF]

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				K. Naruse, S. Fukamachi, H. Mitani, M. Kondo, T. Matsuoka, S. Kondo, N. Hanamura, Y. Morita, K. Hasegawa, R. Nishigaki, et al. A Detailed Linkage Map of Medaka, Oryzias latipes: Comparative Genomics and Genome Evolution Genetics, April 1, 2000; 154(4): 1773 - 1784. [Abstract] [Full Text]

				W Liao, C. Ho, Y. Yan, J Postlethwait, and D. Stainier Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish Development, January 10, 2000; 127(20): 4303 - 4313. [Abstract] [PDF]

				J. Rawls and S. Johnson Zebrafish kit mutation reveals primary and secondary regulation of melanocyte development during fin stripe regeneration Development, January 9, 2000; 127(17): 3715 - 3724. [Abstract] [PDF]

				C. Miller, T. Schilling, K Lee, J Parker, and C. Kimmel sucker encodes a zebrafish Endothelin-1 required for ventral pharyngeal arch development Development, January 9, 2000; 127(17): 3815 - 3828. [Abstract] [PDF]

				C. Beattie, E Melancon, and J. Eisen Mutations in the stumpy gene reveal intermediate targets for zebrafish motor axons Development, January 6, 2000; 127(12): 2653 - 2662. [Abstract] [PDF]

				A. Nechiporuk, J. E. Finney, M. T. Keating, and S. L. Johnson Assessment of Polymorphism in Zebrafish Mapping Strains Genome Res., December 1, 1999; 9(12): 1231 - 1238. [Abstract] [Full Text]

				M. Ohtsuka, S. Makino, K. Yoda, H. Wada, K. Naruse, H. Mitani, A. Shima, K. Ozato, M. Kimura, and H. Inoko Construction of a Linkage Map of the Medaka (Oryzias latipes) and Mapping of the Da Mutant Locus Defective in Dorsoventral Patterning Genome Res., December 1, 1999; 9(12): 1277 - 1287. [Abstract] [Full Text]

				A. C. Oates, A. Brownlie, S. J. Pratt, D. V. Irvine, E. C. Liao, B. H. Paw, K. J. Dorian, S. L. Johnson, J. H. Postlethwait, L. I. Zon, et al. Gene Duplication of Zebrafish JAK2 Homologs Is Accompanied by Divergent Embryonic Expression Patterns: Only jak2a Is Expressed During Erythropoiesis Blood, October 15, 1999; 94(8): 2622 - 2636. [Abstract] [Full Text] [PDF]

				N. A. Hukriede, L. Joly, M. Tsang, J. Miles, P. Tellis, J. A. Epstein, W. B. Barbazuk, F. N. Li, B. Paw, J. H. Postlethwait, et al. Radiation hybrid mapping of the zebrafish genome PNAS, August 17, 1999; 96(17): 9745 - 9750. [Abstract] [Full Text] [PDF]

				M. A. Gates, L. Kim, E. S. Egan, T. Cardozo, H. I. Sirotkin, S. T. Dougan, D. Lashkari, R. Abagyan, A. F. Schier, and W. S. Talbot A Genetic Linkage Map for Zebrafish: Comparative Analysis and Localization of Genes and Expressed Sequences Genome Res., April 1, 1999; 9(4): 334 - 347. [Abstract] [Full Text]

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				D. Parichy, J. Rawls, S. Pratt, T. Whitfield, and S. Johnson Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development Development, January 8, 1999; 126(15): 3425 - 3436. [Abstract] [PDF]

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				T. D. Kocher, W.-J. Lee, H. Sobolewska, D. Penman, and B. McAndrew A Genetic Linkage Map of a Cichlid Fish, the Tilapia (Oreochromis niloticus) Genetics, March 1, 1998; 148(3): 1225 - 1232. [Abstract] [Full Text] [PDF]

				C. Moens, S. Cordes, M. Giorgianni, G. Barsh, and C. Kimmel Equivalence in the genetic control of hindbrain segmentation in fish and mouse Development, January 2, 1998; 125(3): 381 - 391. [Abstract] [PDF]