- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Duffy, J. B.
- Articles by Gergen, J. P.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Duffy, J. B.
- Articles by Gergen, J. P.
Genetics, Vol 142, 839-852, Copyright © 1996
INVESTIGATIONS |
Dosage-Sensitive Maternal Modifiers of the Drosophila Segmentation Gene runt
J. B. Duffy, J. Wells and J. P. Gergen
Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, New York 11794-5215 Current address: Howard Hughes Medical Institute, Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309-0347.
The protein encoded by the pair-rule gene runt functions as a transcriptional regulator during anterior-posterior patterning of the Drosophila embryo. Results of over-expression experiments as well as parallels drawn from the recent characterization of vertebrate homologues indicate that interactions with other proteins are likely to be central to the function of the Runt protein. To identify factors important for runt activity, we took advantage of an adult visible phenotype observed in animals heterozygous for runt mutations. Using a set of 126 different deficiency chromosomes we screened ~65% of the genome for genes that act as dose-sensitive maternal modifiers of runt. Eighteen deficiencies representing 12 putative loci were identified as maternally acting enhancers of runt haplo-insufficiency. Further characterization of two of these regions led to the identification of the interacting loci. Both of these loci affect the spatial regulation of runt transcription and appear genetically complex. Furthermore, the effects of one of these loci, M(1)1B, is indirect and mediated through effects on the transcriptional regulation of posterior gap genes.
This article has been cited by other articles:
 |
|
 |
|
  M. W. Kankel, D. M. Duncan, and I. Duncan A Screen for Genes That Interact With the Drosophila Pair-Rule Segmentation Gene fushi tarazu Genetics, September 1, 2004; 168(1): 161 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Duffy, D. Harrison, and N Perrimon Identifying loci required for follicular patterning using directed mosaics Development, January 6, 1998; 125(12): 2263 - 2271. [Abstract] [PDF]
|
|