Genetics, Vol 141, 1605-1617, Copyright © 1995

INVESTIGATIONS

Deleterious Background Selection With Recombination

R. R. Hudson and N. L. Kaplan
Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92717

An analytic expression for the expected nucleotide diversity is obtained for a neutral locus in a region with deleterious mutation and recombination. Our analytic results are used to predict levels of variation for the entire third chromosome of Drosophila melanogaster. The predictions are consistent with the low levels of variation that have been observed at loci near the centromeres of the third chromosome of D. melanogaster. However, the low levels of variation observed near the tips of this chromosome are not predicted using currently available estimates of the deleterious mutation rate and of selection coefficients. If considerably smaller selection coefficients are assumed, the low observed levels of variation at the tips of the third chromosome are consistent with the background selection model.


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