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Genetics, Vol 141, 1563-1571, Copyright © 1995
INVESTIGATIONS |
Molecular Analysis of 36 Mutations at the Mouse pink-eyed dilution (p) Locus
D. K. Johnson, L. J. Stubbs, C. T. Culiat, C. S. Montgomery, L. B. Russell and E. M. Rinchik
Biology Division Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-8077
Thirty-six radiation- or chemically induced homozygous-lethal mutations at the p locus in mouse chromosome 7 have been analyzed at 17 loci defined by molecular probes to determine the types of lesions, numbers of p-region markers deleted or rearranged, regions of overlap of deletion mutations, and genetic distances between loci. A linear deletion map of the [Myod1, Ldh3]-[Snrpn, Znf127] region has been constructed from the molecular analyses of the p-locus deletions. The utility of these deletions as tools for the isolation and characterization of the genes specifying the neurological, reproductive, and developmental phenotypes genetically mapped to this region will grow as more detailed molecular analyses continue.
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