- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Horabin, J. I.
- Articles by Schedl, P.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Horabin, J. I.
- Articles by Schedl, P.
Genetics, Vol 141, 1521-1535, Copyright © 1995
INVESTIGATIONS |
Selection and Maintenance of Sexual Identity in the Drosophila Germline
J. I. Horabin, D. Bopp, J. Waterbury and P. Schedl
Present address: Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294.
Unlike sex determination in the soma, which is an autonomous process, sex determination in the germline of Drosophila has both inductive and autonomous components. In this paper, we examined how sexual identity is selected and maintained in the Drosophila germline. We show that female-specific expression of genes in the germline is dependent on a somatic signaling pathway. This signaling pathway requires the sex-non-specific transformer 2 gene but, surprisingly, does not appear to require the sex-specific genes, transformer and doublesex. Moreover, in contrast to the soma where pathway initiation and maintenance are independent processes, the somatic signaling pathway appears to function continuously from embryogenesis to the larval stages to select and sustain female germline identity. We also show that the primary target for the somatic signaling pathway in germ cells can not be the Sex-lethal gene.
This article has been cited by other articles:
 |
|
 |
|
  D. S. Evans and T. W. Cline Drosophila melanogaster Male Somatic Cells Feminized Solely by TraF Can Collaborate With Female Germ Cells to Make Functional Eggs Genetics, February 1, 2007; 175(2): 631 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Casper and M. Van Doren The control of sexual identity in the Drosophila germline Development, August 1, 2006; 133(15): 2783 - 2791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Andrews and B. Oliver Sex Determination Signals Control ovo-B Transcription in Drosophila melanogaster Germ Cells Genetics, February 1, 2002; 160(2): 537 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Waterbury, J. I. Horabin, D. Bopp, and P. Schedl Sex Determination in the Drosophila Germline Is Dictated by the Sexual Identity of the Surrounding Soma Genetics, August 1, 2000; 155(4): 1741 - 1756. [Abstract] [Full Text]
|
|
|
|
|
|
A Bhattacharya, S Sudha, H. Chandra, and R Steward flex, an X-linked female-lethal mutation in Drosophila melanogaster controls the expression of Sex-lethal Development, January 12, 1999; 126(23): 5485 - 5493. [Abstract] [PDF]
|
|
|
|
|
|
D Bopp, C Schutt, J Puro, H Huang, and R Nothiger Recombination and disjunction in female germ cells of Drosophila depend on the germline activity of the gene sex-lethal Development, January 12, 1999; 126(24): 5785 - 5794. [Abstract] [PDF]
|
|
|
|
|
|
I Sahut-Barnola and D Pauli The Drosophila gene stand still encodes a germline chromatin-associated protein that controls the transcription of the ovarian tumor gene Development, January 5, 1999; 126(9): 1917 - 1926. [Abstract] [PDF]
|
|
|
|
|
|
M Meise, D Hilfiker-Kleiner, A Dubendorfer, C Brunner, R Nothiger, and D Bopp Sex-lethal, the master sex-determining gene in Drosophila, is not sex-specifically regulated in Musca domestica Development, January 4, 1998; 125(8): 1487 - 1494. [Abstract] [PDF]
|
|
|
|
|
|
C SchuLtt, A Hilfiker, and R Nothiger virilizer regulates Sex-lethal in the germline of Drosophila melanogaster Development, January 4, 1998; 125(8): 1501 - 1507. [Abstract] [PDF]
|
|
|
|
|
|
J. Hager and T. Cline Induction of female Sex-lethal RNA splicing in male germ cells: implications for Drosophila germline sex determination Development, January 12, 1997; 124(24): 5033 - 5048. [Abstract] [PDF]
|
|
|
|
|
|
L. Keyes and A. Spradling The Drosophila gene fs(2)cup interacts with otu to define a cytoplasmic pathway required for the structure and function of germ-line chromosomes Development, January 4, 1997; 124(7): 1419 - 1431. [Abstract] [PDF]
|
|
|
|
|
|
S Staab, A Heller, and M Steinmann-Zwicky Somatic sex-determining signals act on XX germ cells in Drosophila embryos Development, January 12, 1996; 122(12): 4065 - 4071. [Abstract] [PDF]
|
|
|
|
|
|
M Mevel-Ninio, E Fouilloux, I Guenal, and A Vincent The three dominant female-sterile mutations of the Drosophila ovo gene are point mutations that create new translation-initiator AUG codons Development, January 12, 1996; 122(12): 4131 - 4138. [Abstract] [PDF]
|
|