Identification and Cloning of unc-119, a Gene Expressed in the Caenorhabditis elegans Nervous System

INVESTIGATIONS

Identification and Cloning of unc-119, a Gene Expressed in the Caenorhabditis elegans Nervous System

M. Maduro and D. Pilgrim
Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada

A spontaneous mutation affecting locomotion of the nematode Caenorhabditis elegans has been mapped to a new gene, unc-119. Phenotypic characterization of the mutants suggests the defect does not lie in the musculature and that the animals also have defects in feeding behavior and chemosensation. unc-119 has been physically mapped relative to a previously identified chromosomal break in linkage group III, and DNA clones covering the region can rescue the mutant phenotype in transgenic animals. Three more alleles at the locus, with identical phenotypes, have been induced and characterized, all of which are putative null alleles. The predicted UNC-119 protein has no significant similarity to other known proteins. Expression of an unc-119/lacZ fusion in transgenic animals is seen in many neurons, suggesting that the unc-119 mutant phenotype is due to a defect in the nervous system.

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				L. K. Schroeder, S. Kremer, M. J. Kramer, E. Currie, E. Kwan, J. L. Watts, A. L. Lawrenson, and G. J. Hermann Function of the Caenorhabditis elegans ABC Transporter PGP-2 in the Biogenesis of a Lysosome-related Fat Storage Organelle Mol. Biol. Cell, March 1, 2007; 18(3): 995 - 1008. [Abstract] [Full Text] [PDF]

				S. E. Von Stetina, R. M. Fox, K. L. Watkins, T. A. Starich, J. E. Shaw, and D. M. Miller III UNC-4 represses CEH-12/HB9 to specify synaptic inputs to VA motor neurons in C. elegans Genes & Dev., February 1, 2007; 21(3): 332 - 346. [Abstract] [Full Text] [PDF]

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				J. A. Smith, P. McGarr, and J. S. Gilleard The Caenorhabditis elegans GATA factor elt-1 is essential for differentiation and maintenance of hypodermal seam cells and for normal locomotion J. Cell Sci., December 15, 2005; 118(24): 5709 - 5719. [Abstract] [Full Text] [PDF]

				K. Sha and A. Fire Imprinting Capacity of Gamete Lineages in Caenorhabditis elegans Genetics, August 1, 2005; 170(4): 1633 - 1652. [Abstract] [Full Text] [PDF]

				D. Touroutine, R. M. Fox, S. E. Von Stetina, A. Burdina, D. M. Miller III, and J. E. Richmond acr-16 Encodes an Essential Subunit of the Levamisole-resistant Nicotinic Receptor at the Caenorhabditis elegans Neuromuscular Junction J. Biol. Chem., July 22, 2005; 280(29): 27013 - 27021. [Abstract] [Full Text] [PDF]

				L. R. Baugh, A. A. Hill, J. M. Claggett, K. Hill-Harfe, J. C. Wen, D. K. Slonim, E. L. Brown, and C. P. Hunter The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo Development, April 15, 2005; 132(8): 1843 - 1854. [Abstract] [Full Text] [PDF]

				T. Inoue, M. Wang, T. O. Ririe, J. S. Fernandes, and P. W. Sternberg Gene Regulatory Networks Special Feature: Transcriptional network underlying Caenorhabditis elegans vulval development PNAS, April 5, 2005; 102(14): 4972 - 4977. [Abstract] [Full Text] [PDF]

				C. M. Dempsey, S. M. Mackenzie, A. Gargus, G. Blanco, and J. Y. Sze Serotonin (5HT), Fluoxetine, Imipramine and Dopamine Target Distinct 5HT Receptor Signaling to Modulate Caenorhabditis elegans Egg-Laying Behavior Genetics, March 1, 2005; 169(3): 1425 - 1436. [Abstract] [Full Text] [PDF]

				C. Y. Benard, H. Kebir, S. Takagi, and S. Hekimi mau-2 acts cell-autonomously to guide axonal migrations in Caenorhabditis elegans Development, December 1, 2004; 131(23): 5947 - 5958. [Abstract] [Full Text] [PDF]

				E. Veljkovic, A. Bacconi, A. Stetak, A. Hajnal, S. Stasiuk, P. J. Skelly, I. Forster, C. B. Shoemaker, and F. Verrey Aromatic Amino Acid Transporter AAT-9 of Caenorhabditis elegans Localizes to Neurons and Muscle Cells J. Biol. Chem., November 19, 2004; 279(47): 49268 - 49273. [Abstract] [Full Text] [PDF]