Genetics, Vol 141, 977-988, Copyright © 1995

INVESTIGATIONS

Identification and Cloning of unc-119, a Gene Expressed in the Caenorhabditis elegans Nervous System

M. Maduro and D. Pilgrim
Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada

A spontaneous mutation affecting locomotion of the nematode Caenorhabditis elegans has been mapped to a new gene, unc-119. Phenotypic characterization of the mutants suggests the defect does not lie in the musculature and that the animals also have defects in feeding behavior and chemosensation. unc-119 has been physically mapped relative to a previously identified chromosomal break in linkage group III, and DNA clones covering the region can rescue the mutant phenotype in transgenic animals. Three more alleles at the locus, with identical phenotypes, have been induced and characterized, all of which are putative null alleles. The predicted UNC-119 protein has no significant similarity to other known proteins. Expression of an unc-119/lacZ fusion in transgenic animals is seen in many neurons, suggesting that the unc-119 mutant phenotype is due to a defect in the nervous system.

This article has been cited by other articles:

				T. L. Vrablik, L. Huang, S. E. Lange, and W. Hanna-Rose Nicotinamidase modulation of NAD+ biosynthesis and nicotinamide levels separately affect reproductive development and cell survival in C. elegans Development, November 1, 2009; 136(21): 3637 - 3646. [Abstract] [Full Text] [PDF]

				D. E. Davis, H. C. Roh, K. Deshmukh, J. J. Bruinsma, D. L. Schneider, J. Guthrie, J. D. Robertson, and K. Kornfeld The Cation Diffusion Facilitator Gene cdf-2 Mediates Zinc Metabolism in Caenorhabditis elegans Genetics, August 1, 2009; 182(4): 1015 - 1033. [Abstract] [Full Text] [PDF]

				M. M. Gorska, Q. Liang, Z. Karim, and R. Alam Uncoordinated 119 Protein Controls Trafficking of Lck via the Rab11 Endosome and Is Critical for Immunological Synapse Formation J. Immunol., August 1, 2009; 183(3): 1675 - 1684. [Abstract] [Full Text] [PDF]

				T. O. Ririe, J. S. Fernandes, and P. W. Sternberg Gene Networks in Development and Evolution Special Feature Sackler Colloquium: The Caenorhabditis elegans vulva: A post-embryonic gene regulatory network controlling organogenesis PNAS, December 23, 2008; 105(51): 20095 - 20099. [Abstract] [Full Text] [PDF]

				J. R. Tenlen, J. N. Molk, N. London, B. D. Page, and J. R. Priess MEX-5 asymmetry in one-cell C. elegans embryos requires PAR-4- and PAR-1-dependent phosphorylation Development, November 15, 2008; 135(22): 3665 - 3675. [Abstract] [Full Text] [PDF]

				S. Zhou, K. Opperman, X. Wang, and L. Chen unc-44 Ankyrin and stn-2 {gamma}-Syntrophin Regulate sax-7 L1CAM Function in Maintaining Neuronal Positioning in Caenorhabditis elegans Genetics, November 1, 2008; 180(3): 1429 - 1443. [Abstract] [Full Text] [PDF]

				M. Sato, B. D. Grant, A. Harada, and K. Sato Rab11 is required for synchronous secretion of chondroitin proteoglycans after fertilization in Caenorhabditis elegans J. Cell Sci., October 1, 2008; 121(19): 3177 - 3186. [Abstract] [Full Text] [PDF]

				M. C. Ow, N. J. Martinez, P. H. Olsen, H. S. Silverman, M. I. Barrasa, B. Conradt, A. J.M. Walhout, and V. Ambros The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans Genes & Dev., September 15, 2008; 22(18): 2520 - 2534. [Abstract] [Full Text] [PDF]

				R. Voutev and E. J. A. Hubbard A "FLP-Out" System for Controlled Gene Expression in Caenorhabditis elegans Genetics, September 1, 2008; 180(1): 103 - 119. [Abstract] [Full Text] [PDF]

				E. V. Entchev, D. Schwudke, V. Zagoriy, V. Matyash, A. Bogdanova, B. Habermann, L. Zhu, A. Shevchenko, and T. V. Kurzchalia LET-767 Is Required for the Production of Branched Chain and Long Chain Fatty Acids in Caenorhabditis elegans J. Biol. Chem., June 20, 2008; 283(25): 17550 - 17560. [Abstract] [Full Text] [PDF]

				F. Haeseleer Interaction and Colocalization of CaBP4 and Unc119 (MRG4) in Photoreceptors Invest. Ophthalmol. Vis. Sci., June 1, 2008; 49(6): 2366 - 2375. [Abstract] [Full Text] [PDF]

				H. Lee, J. S. Cho, N. Lambacher, J. Lee, S.-J. Lee, T. H. Lee, A. Gartner, and H.-S. Koo The Caenorhabditis elegans AMP-activated Protein Kinase AAK-2 Is Phosphorylated by LKB1 and Is Required for Resistance to Oxidative Stress and for Normal Motility and Foraging Behavior J. Biol. Chem., May 30, 2008; 283(22): 14988 - 14993. [Abstract] [Full Text] [PDF]

				A. L. Fisher, K. E. Page, G. J. Lithgow, and L. Nash The Caenorhabditis elegans K10C2.4 Gene Encodes a Member of the Fumarylacetoacetate Hydrolase Family: A CAENORHABDITIS ELEGANS MODEL OF TYPE I TYROSINEMIA J. Biol. Chem., April 4, 2008; 283(14): 9127 - 9135. [Abstract] [Full Text] [PDF]

				M. Hebeisen and R. Roy CDC-25.1 stability is regulated by distinct domains to restrict cell division during embryogenesis in C. elegans Development, April 1, 2008; 135(7): 1259 - 1269. [Abstract] [Full Text] [PDF]

				S. Jarriault, Y. Schwab, and I. Greenwald A Caenorhabditis elegans model for epithelial-neuronal transdifferentiation PNAS, March 11, 2008; 105(10): 3790 - 3795. [Abstract] [Full Text] [PDF]

				R. Vepachedu, M. M. Gorska, N. Singhania, G. P. Cosgrove, K. K. Brown, and R. Alam Unc119 Regulates Myofibroblast Differentiation through the Activation of Fyn and the p38 MAPK Pathway J. Immunol., July 1, 2007; 179(1): 682 - 690. [Abstract] [Full Text] [PDF]

				B. D. Page, S. J. Diede, J. R. Tenlen, and E. L. Ferguson EEL-1, a Hect E3 ubiquitin ligase, controls asymmetry and persistence of the SKN-1 transcription factor in the early C. elegans embryo Development, June 15, 2007; 134(12): 2303 - 2314. [Abstract] [Full Text] [PDF]

				G. Ou, M. Koga, O. E. Blacque, T. Murayama, Y. Ohshima, J. C. Schafer, C. Li, B. K. Yoder, M. R. Leroux, and J. M. Scholey Sensory Ciliogenesis in Caenorhabditis elegans: Assignment of IFT Components into Distinct Modules Based on Transport and Phenotypic Profiles Mol. Biol. Cell, May 1, 2007; 18(5): 1554 - 1569. [Abstract] [Full Text] [PDF]

				L. K. Schroeder, S. Kremer, M. J. Kramer, E. Currie, E. Kwan, J. L. Watts, A. L. Lawrenson, and G. J. Hermann Function of the Caenorhabditis elegans ABC Transporter PGP-2 in the Biogenesis of a Lysosome-related Fat Storage Organelle Mol. Biol. Cell, March 1, 2007; 18(3): 995 - 1008. [Abstract] [Full Text] [PDF]

				S. E. Von Stetina, R. M. Fox, K. L. Watkins, T. A. Starich, J. E. Shaw, and D. M. Miller III UNC-4 represses CEH-12/HB9 to specify synaptic inputs to VA motor neurons in C. elegans Genes & Dev., February 1, 2007; 21(3): 332 - 346. [Abstract] [Full Text] [PDF]

				C. Schmitz, P. Kinge, and H. Hutter Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126) PNAS, January 16, 2007; 104(3): 834 - 839. [Abstract] [Full Text] [PDF]

				J. R. Tenlen, J. A. Schisa, S. J. Diede, and B. D. Page Reduced Dosage of pos-1 Suppresses Mex Mutants and Reveals Complex Interactions Among CCCH Zinc-Finger Proteins During Caenorhabditis elegans Embryogenesis Genetics, December 1, 2006; 174(4): 1933 - 1945. [Abstract] [Full Text] [PDF]

				C. Shen, Z. Shao, and J. A. Powell-Coffman The Caenorhabditis elegans rhy-1 Gene Inhibits HIF-1 Hypoxia-Inducible Factor Activity in a Negative Feedback Loop That Does Not Include vhl-1 Genetics, November 1, 2006; 174(3): 1205 - 1214. [Abstract] [Full Text] [PDF]

				D. Park, H. Jia, V. Rajakumar, and H. M. Chamberlin Pax2/5/8 proteins promote cell survival in C. elegans Development, November 1, 2006; 133(21): 4193 - 4202. [Abstract] [Full Text] [PDF]

				M. Beers and K. Kemphues Depletion of the co-chaperone CDC-37 reveals two modes of PAR-6 cortical association in C. elegans embryos Development, October 1, 2006; 133(19): 3745 - 3754. [Abstract] [Full Text] [PDF]

				Y.-K. Bae, H. Qin, K. M. Knobel, J. Hu, J. L. Rosenbaum, and M. M. Barr General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia Development, October 1, 2006; 133(19): 3859 - 3870. [Abstract] [Full Text] [PDF]

				G. Broitman-Maduro, K. T.-H. Lin, W. W. K. Hung, and M. F. Maduro Specification of the C. elegans MS blastomere by the T-box factor TBX-35 Development, August 15, 2006; 133(16): 3097 - 3106. [Abstract] [Full Text] [PDF]

				L. Jia and S. W. Emmons Genes That Control Ray Sensory Neuron Axon Development in the Caenorhabditis elegans Male Genetics, July 1, 2006; 173(3): 1241 - 1258. [Abstract] [Full Text] [PDF]

				K. Sato, M. Sato, A. Audhya, K. Oegema, P. Schweinsberg, and B. D. Grant Dynamic Regulation of Caveolin-1 Trafficking in the Germ Line and Embryo of Caenorhabditis elegans Mol. Biol. Cell, July 1, 2006; 17(7): 3085 - 3094. [Abstract] [Full Text] [PDF]

				N. Mori, Y. Ishiba, S. Kubota, A. Kobayashi, T. Higashide, M. J. McLaren, and G. Inana Truncation Mutation in HRG4 (UNC119) Leads to Mitochondrial ANT-1-Mediated Photoreceptor Synaptic and Retinal Degeneration by Apoptosis. Invest. Ophthalmol. Vis. Sci., April 1, 2006; 47(4): 1281 - 1292. [Abstract] [Full Text] [PDF]

				J. Novelli, A. P. Page, and J. Hodgkin The C Terminus of Collagen SQT-3 Has Complex and Essential Functions in Nematode Collagen Assembly Genetics, April 1, 2006; 172(4): 2253 - 2267. [Abstract] [Full Text] [PDF]

				Y. Kubota, M. Sano, S. Goda, N. Suzuki, and K. Nishiwaki The conserved oligomeric Golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease in C. elegans Development, January 15, 2006; 133(2): 263 - 273. [Abstract] [Full Text] [PDF]

				J. A. Smith, P. McGarr, and J. S. Gilleard The Caenorhabditis elegans GATA factor elt-1 is essential for differentiation and maintenance of hypodermal seam cells and for normal locomotion J. Cell Sci., December 15, 2005; 118(24): 5709 - 5719. [Abstract] [Full Text] [PDF]

				K. Sha and A. Fire Imprinting Capacity of Gamete Lineages in Caenorhabditis elegans Genetics, August 1, 2005; 170(4): 1633 - 1652. [Abstract] [Full Text] [PDF]

				D. Touroutine, R. M. Fox, S. E. Von Stetina, A. Burdina, D. M. Miller III, and J. E. Richmond acr-16 Encodes an Essential Subunit of the Levamisole-resistant Nicotinic Receptor at the Caenorhabditis elegans Neuromuscular Junction J. Biol. Chem., July 22, 2005; 280(29): 27013 - 27021. [Abstract] [Full Text] [PDF]

				L. R. Baugh, A. A. Hill, J. M. Claggett, K. Hill-Harfe, J. C. Wen, D. K. Slonim, E. L. Brown, and C. P. Hunter The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo Development, April 15, 2005; 132(8): 1843 - 1854. [Abstract] [Full Text] [PDF]

				T. Inoue, M. Wang, T. O. Ririe, J. S. Fernandes, and P. W. Sternberg Gene Regulatory Networks Special Feature: Transcriptional network underlying Caenorhabditis elegans vulval development PNAS, April 5, 2005; 102(14): 4972 - 4977. [Abstract] [Full Text] [PDF]

				C. M. Dempsey, S. M. Mackenzie, A. Gargus, G. Blanco, and J. Y. Sze Serotonin (5HT), Fluoxetine, Imipramine and Dopamine Target Distinct 5HT Receptor Signaling to Modulate Caenorhabditis elegans Egg-Laying Behavior Genetics, March 1, 2005; 169(3): 1425 - 1436. [Abstract] [Full Text] [PDF]

				C. Y. Benard, H. Kebir, S. Takagi, and S. Hekimi mau-2 acts cell-autonomously to guide axonal migrations in Caenorhabditis elegans Development, December 1, 2004; 131(23): 5947 - 5958. [Abstract] [Full Text] [PDF]

				E. Veljkovic, A. Bacconi, A. Stetak, A. Hajnal, S. Stasiuk, P. J. Skelly, I. Forster, C. B. Shoemaker, and F. Verrey Aromatic Amino Acid Transporter AAT-9 of Caenorhabditis elegans Localizes to Neurons and Muscle Cells J. Biol. Chem., November 19, 2004; 279(47): 49268 - 49273. [Abstract] [Full Text] [PDF]

				J. Novelli, S. Ahmed, and J. Hodgkin Gene Interactions in Caenorhabditis elegans Define DPY-31 as a Candidate Procollagen C-Proteinase and SQT-3/ROL-4 as Its Predicted Major Target Genetics, November 1, 2004; 168(3): 1259 - 1273. [Abstract] [Full Text] [PDF]

				E. Runko and Z. Kaprielian Caenorhabditis elegans VEM-1, a Novel Membrane Protein, Regulates the Guidance of Ventral Nerve Cord-Associated Axons J. Neurosci., October 13, 2004; 24(41): 9015 - 9026. [Abstract] [Full Text] [PDF]

				V. Jantsch, P. Pasierbek, M. M. Mueller, D. Schweizer, M. Jantsch, and J. Loidl Targeted Gene Knockout Reveals a Role in Meiotic Recombination for ZHP-3, a Zip3-Related Protein in Caenorhabditis elegans Mol. Cell. Biol., September 15, 2004; 24(18): 7998 - 8006. [Abstract] [Full Text] [PDF]

				Z. Chen, D. J. Eastburn, and M. Han The Caenorhabditis elegans Nuclear Receptor Gene nhr-25 Regulates Epidermal Cell Development Mol. Cell. Biol., September 1, 2004; 24(17): 7345 - 7358. [Abstract] [Full Text] [PDF]

				J. Hoflich, P. Berninsone, C. Gobel, M. J. Gravato-Nobre, B. J. Libby, C. Darby, S. M. Politz, J. Hodgkin, C. B. Hirschberg, and R. Baumeister Loss of srf-3-encoded Nucleotide Sugar Transporter Activity in Caenorhabditis elegans Alters Surface Antigenicity and Prevents Bacterial Adherence J. Biol. Chem., July 16, 2004; 279(29): 30440 - 30448. [Abstract] [Full Text] [PDF]

				E. Berezikov, C. I. Bargmann, and R. H. A. Plasterk Homologous gene targeting in Caenorhabditis elegans by biolistic transformation Nucleic Acids Res., February 24, 2004; 32(4): e40 - e40. [Abstract] [Full Text] [PDF]

				G. Kao, S. Tuck, D. Baillie, and M. V. Sundaram C. elegans SUR-6/PR55 cooperates with LET-92/protein phosphatase 2A and promotes Raf activity independently of inhibitory Akt phosphorylation sites Development, February 15, 2004; 131(4): 755 - 765. [Abstract] [Full Text] [PDF]

				M. M. Gorska, S. J. Stafford, O. Cen, S. Sur, and R. Alam Unc119, a Novel Activator of Lck/Fyn, Is Essential for T Cell Activation J. Exp. Med., February 2, 2004; 199(3): 369 - 379. [Abstract] [Full Text] [PDF]

				L. I. Grad and B. D. Lemire Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis Hum. Mol. Genet., February 1, 2004; 13(3): 303 - 314. [Abstract] [Full Text] [PDF]

				L. S. da Graca, K. K. Zimmerman, M. C. Mitchell, M. Kozhan-Gorodetska, K. Sekiewicz, Y. Morales, and G. I. Patterson,, DAF-5 is a Ski oncoprotein homolog that functions in a neuronal TGF{beta} pathway to regulate C. elegans dauer development Development, January 15, 2004; 131(2): 435 - 446. [Abstract] [Full Text] [PDF]

				K. R. Siegfried, A. R. Kidd III, M. A. Chesney, and J. Kimble The sys-1 and sys-3 Genes Cooperate With Wnt Signaling to Establish the Proximal-Distal Axis of the Caenorhabditis elegans Gonad Genetics, January 1, 2004; 166(1): 171 - 186. [Abstract] [Full Text] [PDF]

				G. M. Lesa, M. Palfreyman, D. H. Hall, M. T. Clandinin, C. Rudolph, E. M. Jorgensen, and G. Schiavo Long chain polyunsaturated fatty acids are required for efficient neurotransmission in C. elegans J. Cell Sci., December 15, 2003; 116(24): 4965 - 4975. [Abstract] [Full Text] [PDF]

				V. Galy, I. W. Mattaj, and P. Askjaer Caenorhabditis elegans Nucleoporins Nup93 and Nup205 Determine the Limit of Nuclear Pore Complex Size Exclusion In Vivo Mol. Biol. Cell, December 1, 2003; 14(12): 5104 - 5115. [Abstract] [Full Text] [PDF]

				J. Nance, E. M. Munro, and J. R. Priess C. elegans PAR-3 and PAR-6 are required for apicobasal asymmetries associated with cell adhesion and gastrulation Development, November 15, 2003; 130(22): 5339 - 5350. [Abstract] [Full Text] [PDF]

				I. Ruvinsky and G. Ruvkun Functional tests of enhancer conservation between distantly related species Development, November 1, 2003; 130(21): 5133 - 5142. [Abstract] [Full Text] [PDF]

				H. Yu, R. F. Pretot, T. R. Burglin, and P. W. Sternberg Distinct roles of transcription factors EGL-46 and DAF-19 in specifying the functionality of a polycystin-expressing sensory neuron necessary for C. elegans male vulva location behavior Development, November 1, 2003; 130(21): 5217 - 5227. [Abstract] [Full Text] [PDF]

				S. Chang, R. J. Johnston Jr., and O. Hobert A transcriptional regulatory cascade that controls left/right asymmetry in chemosensory neurons of C. elegans Genes & Dev., September 1, 2003; 17(17): 2123 - 2137. [Abstract] [Full Text] [PDF]

				X. Huang, P. Huang, M. K. Robinson, M. J. Stern, and Y. Jin UNC-71, a disintegrin and metalloprotease (ADAM) protein, regulates motor axon guidance and sex myoblast migration in C. elegans Development, July 15, 2003; 130(14): 3147 - 3161. [Abstract] [Full Text] [PDF]

				D. S. Fay, E. Large, M. Han, and M. Darland lin-35/Rb and ubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control pharyngeal morphogenesis in C. elegans Development, July 15, 2003; 130(14): 3319 - 3330. [Abstract] [Full Text] [PDF]

				L. Timmons, H. Tabara, C. C. Mello, and A. Z. Fire Inducible Systemic RNA Silencing in Caenorhabditis elegans Mol. Biol. Cell, July 1, 2003; 14(7): 2972 - 2983. [Abstract] [Full Text] [PDF]

				G. Battu, E. F. Hoier, and A. Hajnal The C. elegans G-protein-coupled receptor SRA-13 inhibits RAS/MAPK signalling during olfaction and vulval development Development, June 15, 2003; 130(12): 2567 - 2577. [Abstract] [Full Text] [PDF]

				O. Cen, M. M. Gorska, S. J. Stafford, S. Sur, and R. Alam Identification of UNC119 as a Novel Activator of SRC-type Tyrosine Kinases J. Biol. Chem., February 28, 2003; 278(10): 8837 - 8845. [Abstract] [Full Text] [PDF]

				Y. Suzuki, G. A. Morris, M. Han, and W. B. Wood A Cuticle Collagen Encoded by the lon-3 Gene May Be a Target of TGF-{beta} Signaling in Determining Caenorhabditis elegans Body Shape Genetics, December 1, 2002; 162(4): 1631 - 1639. [Abstract] [Full Text] [PDF]

				P. Askjaer, V. Galy, E. Hannak, and I. W. Mattaj Ran GTPase Cycle and Importins alpha and beta Are Essential for Spindle Formation and Nuclear Envelope Assembly in Living Caenorhabditis elegans Embryos Mol. Biol. Cell, December 1, 2002; 13(12): 4355 - 4370. [Abstract] [Full Text] [PDF]

				O. I. Petriv, D. B. Pilgrim, R. A. Rachubinski, and V. I. Titorenko RNA interference of peroxisome-related genes in C. elegans: a new model for human peroxisomal disorders Physiol Genomics, August 14, 2002; 10(2): 79 - 91. [Abstract] [Full Text] [PDF]

				V. Nancy, I. Callebaut, A. El Marjou, and J. de Gunzburg The delta Subunit of Retinal Rod cGMP Phosphodiesterase Regulates the Membrane Association of Ras and Rap GTPases J. Biol. Chem., April 19, 2002; 277(17): 15076 - 15084. [Abstract] [Full Text] [PDF]

				S. Kubota, A. Kobayashi, N. Mori, T. Higashide, M. J. McLaren, and G. Inana Changes in Retinal Synaptic Proteins in the Transgenic Model Expressing a Mutant HRG4 (UNC119) Invest. Ophthalmol. Vis. Sci., February 1, 2002; 43(2): 308 - 313. [Abstract] [Full Text] [PDF]

				Z. Chen and M. Han Role of C. elegans lin-40 MTA in vulval fate specification and morphogenesis Development, December 1, 2001; 128(23): 4911 - 4921. [Abstract] [Full Text] [PDF]

				K. M. Knobel, W. S. Davis, E. M. Jorgensen, and M. J. Bastiani UNC-119 suppresses axon branching in C. elegans Development, October 15, 2001; 128(20): 4079 - 4092. [Abstract] [Full Text] [PDF]

				A. D. Johnson, D. Fitzsimmons, J. Hagman, and H. M. Chamberlin EGL-38 Pax regulates the ovo-related gene lin-48 during Caenorhabditis elegans organ development Development, August 1, 2001; 128(15): 2857 - 2865. [Abstract] [Full Text] [PDF]

				Z. Altun-Gultekin, Y. Andachi, E. L. Tsalik, D. Pilgrim, Y. Kohara, and O. Hobert A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans Development, June 1, 2001; 128(11): 1951 - 1969. [Abstract] [Full Text] [PDF]

				C. Tenenhaus, K. Subramaniam, M. A. Dunn, and G. Seydoux PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegans Genes & Dev., April 15, 2001; 15(8): 1031 - 1040. [Abstract] [Full Text]

				V. Praitis, E. Casey, D. Collar, and J. Austin Creation of Low-Copy Integrated Transgenic Lines in Caenorhabditis elegans Genetics, March 1, 2001; 157(3): 1217 - 1226. [Abstract] [Full Text]

				B. Vogel and E. Hedgecock Hemicentin, a conserved extracellular member of the immunoglobulin superfamily, organizes epithelial and other cell attachments into oriented line-shaped junctions Development, January 3, 2001; 128(6): 883 - 894. [Abstract] [PDF]

				C. A. Wolkow, K. D. Kimura, M.-S. Lee, and G. Ruvkun Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System Science, October 6, 2000; 290(5489): 147 - 150. [Abstract] [Full Text]

				A. Kobayashi, T. Higashide, D. Hamasaki, S. Kubota, H. Sakuma, W. An, T. Fujimaki, M. J. McLaren, R. G. Weleber, and G. Inana HRG4 (UNC119) Mutation Found in Cone-Rod Dystrophy Causes Retinal Degeneration in a Transgenic Model Invest. Ophthalmol. Vis. Sci., October 1, 2000; 41(11): 3268 - 3277. [Abstract] [Full Text]

				A. F. Dernburg, J. Zalevsky, M. P. Colaiácovo, and A. M. Villeneuve Transgene-mediated cosuppression in the C. elegans germ line Genes & Dev., July 1, 2000; 14(13): 1578 - 1583. [Abstract] [Full Text]

				K. Nishiwaki, N. Hisamoto, and K. Matsumoto A Metalloprotease Disintegrin That Controls Cell Migration in Caenorhabditis elegans Science, June 23, 2000; 288(5474): 2205 - 2208. [Abstract] [Full Text]

				E. F. Hoier, W. A. Mohler, S. K. Kim, and A. Hajnal The Caenorhabditis elegans APC-related gene apr-1 is required for epithelial cell migration and Hox gene expression Genes & Dev., April 1, 2000; 14(7): 874 - 886. [Abstract] [Full Text]

				T von Zelewsky, F Palladino, K Brunschwig, H Tobler, A Hajnal, and F Muller The C. elegans Mi-2 chromatin-remodelling proteins function in vulval cell fate determination Development, January 12, 2000; 127(24): 5277 - 5284. [Abstract] [PDF]

				H. Chamberlin and J. Thomas The bromodomain protein LIN-49 and trithorax-related protein LIN-59 affect development and gene expression in Caenorhabditis elegans Development, January 2, 2000; 127(4): 713 - 723. [Abstract] [PDF]

				J. Hsieh, J. Liu, S. A. Kostas, C. Chang, P. W. Sternberg, and A. Fire The RING finger/B-Box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans Genes & Dev., November 15, 1999; 13(22): 2958 - 2970. [Abstract] [Full Text]

				L. H. Moilanen, T. Fukushige, and J. H. Freedman Regulation of Metallothionein Gene Transcription. IDENTIFICATION OF UPSTREAM REGULATORY ELEMENTS AND TRANSCRIPTION FACTORS RESPONSIBLE FOR CELL-SPECIFIC EXPRESSION OF THE METALLOTHIONEIN GENES FROM CAENORHABDITIS ELEGANS J. Biol. Chem., October 15, 1999; 274(42): 29655 - 29665. [Abstract] [Full Text] [PDF]

				D. S. Sieburth, M. Sundaram, R. M. Howard, and M. Han A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction Genes & Dev., October 1, 1999; 13(19): 2562 - 2569. [Abstract] [Full Text]

				D. E. Cikaluk, N. Tahbaz, L. C. Hendricks, G. E. DiMattia, D. Hansen, D. Pilgrim, and T. C. Hobman GERp95, a Membrane-associated Protein that Belongs to a Family of Proteins Involved in Stem Cell Differentiation Mol. Biol. Cell, October 1, 1999; 10(10): 3357 - 3372. [Abstract] [Full Text]

				Y.-S. Lim, S. Mallapur, G. Kao, X.-C. Ren, and W. G. Wadsworth Netrin UNC-6 and the Regulation of Branching and Extension of Motoneuron Axons from the Ventral Nerve Cord of Caenorhabditis elegans J. Neurosci., August 15, 1999; 19(16): 7048 - 7056. [Abstract] [Full Text] [PDF]

				S Kim, X. Ren, E Fox, and W. Wadsworth SDQR migrations in Caenorhabditis elegans are controlled by multiple guidance cues and changing responses to netrin UNC-6 Development, January 9, 1999; 126(17): 3881 - 3890. [Abstract] [PDF]

				K Brunschwig, C Wittmann, R Schnabel, T. Burglin, H Tobler, and F Muller Anterior organization of the Caenorhabditis elegans embryo by the labial-like Hox gene ceh-13 Development, January 4, 1999; 126(7): 1537 - 1546. [Abstract] [PDF]

				W Hanna-Rose and M Han COG-2, a sox domain protein necessary for establishing a functional vulval-uterine connection in Caenorhabditis elegans Development, January 1, 1999; 126(1): 169 - 179. [Abstract] [PDF]

				Y Suzuki, M. Yandell, P. Roy, S Krishna, C Savage-Dunn, R. Ross, R. Padgett, and W. Wood A BMP homolog acts as a dose-dependent regulator of body size and male tail patterning in Caenorhabditis elegans Development, January 1, 1999; 126(2): 241 - 250. [Abstract] [PDF]

				M. R. Lackner and S. K. Kim Genetic Analysis of the Caenorhabditis elegans MAP Kinase Gene mpk-1 Genetics, September 1, 1998; 150(1): 103 - 117. [Abstract] [Full Text]

				T. Gu, S. Orita, and M. Han Caenorhabditis elegans SUR-5, a Novel but Conserved Protein, Negatively Regulates LET-60 Ras Activity during Vulval Induction Mol. Cell. Biol., August 1, 1998; 18(8): 4556 - 4564. [Abstract] [Full Text]

				J. Yochem, T. Gu, and M. Han A New Marker for Mosaic Analysis in Caenorhabditis elegans Indicates a Fusion Between hyp6 and hyp7, Two Major Components of the Hypodermis Genetics, July 1, 1998; 149(3): 1323 - 1334. [Abstract] [Full Text] [PDF]