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Genetics, Vol 141, 903-907, Copyright © 1995
INVESTIGATIONS |
Evolutionary Origin of Nonuniversal CUG(Ser) Codon in Some Candida Species as Inferred From a Molecular Phylogeny
G. Pesole, M. Lotti, L. Alberghina and C. Saccone
Dipartimento di Biochimica e Biologia Molecolare and Centro Studi sui Mitocondri e Metabolismo Energetico Consiglio Nazionale delle Ricerche, Universita di Bari, 70126 Bari, Italy
CUG, a universal leucine codon, has been reported to be read as serine in various yeast species belonging to the genus Candida. To gain a deeper insight into the origin of this deviation from the universal genetic code, we carried out a phylogenetic analysis based on the small-subunit ribosomal RNA genes from some Candida and other related Hemiascomycetes. Furthermore, we determined the phylogenetic relationships between the tRNA(Ser)CAG, responsible for the translation of CUG, from some Candida species and the other serine and leucine isoacceptor tRNAs in C. cylindracea. We demonstrate that the group of Candida showing the genetic code deviation is monophiletic and that this deviation could have been originated more than 150 million years ago. We also describe how phylogenetic analysis can be used for genetic code predictions.
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