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Genetics, Vol 141, 857-871, Copyright © 1995
INVESTIGATIONS |
LAS1 Is an Essential Nuclear Protein Involved in Cell Morphogenesis and Cell Surface Growth
A. I. Doseff and K. T. Arndt
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724-2212 and Graduate Program in Genetics, State University of New York, Stony Brook, New York 11794
Saccharomyces cerevisiae mutations that cause a requirement for SSD1-v for viability were isolated, yielding one new gene, LAS1, and three previously identified genes, SIT4, BCK1/SLK1, and SMP3. Three of these genes, LAS1, SIT4, and BCK1/SLK1, encode proteins that have roles in bud formation or morphogenesis. LAS1 is essential and loss of LAS1 function causes the cells to arrest as 80% unbudded cells and 20% large budded cells that accumulate many vesicles at the mother-daughter neck. Overexpression of LAS1 results in extra cell surface projections in the mother cell, alterations in actin and SPA2 localization, and the accumulation of electron-dense structures along the periphery of both the mother cell and the bud. The nuclear localization of LAS1 suggests a role of LAS1 for regulating bud formation and morphogenesis via the expression of components that function directly in these processes.
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