Advanced Intercross Lines, an Experimental Population for Fine Genetic Mapping

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Advanced Intercross Lines, an Experimental Population for Fine Genetic Mapping

A. Darvasi and M. Soller
Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel

An advanced intercrossed line (AIL) is an experimental population that can provide more accurate estimates of quantitative trait loci (QTL) map location than conventional mapping populations. An AIL is produced by randomly and sequentially intercrossing a population that initially originated from a cross between two inbred lines or some variant thereof. This provides increasing probability of recombination between any two loci. Consequently, the genetic length of the entire genome is stretched, providing increased mapping resolution. In this way, for example, with the same population size and QTL effect, a 95% confidence interval of QTL map location of 20 cM in the F(2) is reduced fivefold after eight additional random mating generations (F(10)). Simulation results showed that to obtain the anticipated reduction in the confidence interval, breeding population size of the AIL in all generations should comprise an effective number of >/=100 individuals. It is proposed that AILs derived from crosses between known inbred lines may be a useful resource for fine genetic mapping.

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				J. R. Sheng, M. Jagodic, I. Dahlman, K. Becanovic, R. Nohra, M. Marta, E. Iacobaeus, T. Olsson, and E. Wallstrom Eae19, a New Locus on Rat Chromosome 15 Regulating Experimental Autoimmune Encephalomyelitis Genetics, May 1, 2005; 170(1): 283 - 289. [Abstract] [Full Text] [PDF]

				K. E. Bennett, D. Flick, K. H. Fleming, R. Jochim, B. J. Beaty, and W. C. Black IV Quantitative Trait Loci That Control Dengue-2 Virus Dissemination in the Mosquito Aedes aegypti Genetics, May 1, 2005; 170(1): 185 - 194. [Abstract] [Full Text] [PDF]

				J.-L. Jannink Selective Phenotyping to Accurately Map Quantitative Trait Loci Crop Sci., March 28, 2005; 45(3): 901 - 908. [Abstract] [Full Text] [PDF]

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				A. K. Bauer, A. M. Malkinson, and S. R. Kleeberger Susceptibility to neoplastic and non-neoplastic pulmonary diseases in mice: genetic similarities Am J Physiol Lung Cell Mol Physiol, October 1, 2004; 287(4): L685 - L703. [Abstract] [Full Text] [PDF]

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