- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Otto, S. P.
- Articles by Orive, M. E.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Otto, S. P.
- Articles by Orive, M. E.
Genetics, Vol 141, 1173-1187, Copyright © 1995
INVESTIGATIONS |
Evolutionary Consequences of Mutation and Selection Within an Individual
S. P. Otto and M. E. Orive
Institute of Cellular, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
Whether in sexual or asexual organisms, selection among cell lineages during development is an effective way of eliminating deleterious mutations. Using a mathematical analysis, we find that relatively small differences in cell replication rates during development can translate into large differences in the proportion of mutant cells within the adult, especially when development involves a large number of cell divisions. Consequently, intraorganismal selection can substantially reduce the deleterious mutation rate observed among offspring as well as the mutation load within a population, because cells rather than individuals provide the selective ``deaths'' necessary to stem the tide of deleterious mutations. The reduction in mutation rate among offspring is more pronounced in organisms with plastic development than in those with structured development. It is also more pronounced in asexual organisms that produce multicellular rather than unicellular offspring. By effecting the mutation rate, intraorganismal selection may have broad evolutionary implications; as an example, we consider its influence on the evolution of ploidy levels, finding that cell-lineage selection is more effective in haploids and tends to favor their evolution.
This article has been cited by other articles:
 |
|
 |
|
  P. J. Taylor, S. M. Eppley, and L. K. Jesson Sporophytic inbreeding depression in mosses occurs in a species with separate sexes but not in a species with combined sexes Am. J. Botany, November 1, 2007; 94(11): 1853 - 1859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Joseph and D. W. Hall Spontaneous Mutations in Diploid Saccharomyces cerevisiae: More Beneficial Than Expected Genetics, December 1, 2004; 168(4): 1817 - 1825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Whitlock Selection, Load and Inbreeding Depression in a Large Metapopulation Genetics, March 1, 2002; 160(3): 1191 - 1202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Shaw, D. L. Byers, and E. Darmo Spontaneous Mutational Effects on Reproductive Traits of Arabidopsis thaliana Genetics, May 1, 2000; 155(1): 369 - 378. [Abstract] [Full Text]
|
|