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Genetics, Vol 141, 1037-1042, Copyright © 1995
INVESTIGATIONS |
The Triplo-lethal Locus of Drosophila: Reexamination of Mutants and Discovery of a Second-Site Suppressor
D. R. Dorer, D. H. Ezekiel and A. C. Christensen
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5541 Present address: Division of Basic Sciences A1-162, Fred Hutchinson Cancer Research Center, 1124 Columbia St., Seattle, WA 98104.
In the genome of Drosophila melanogaster there is a single locus, Triplo-lethal (Tpl), that causes lethality when present in either one or three copies in an otherwise diploid animal. Previous attempts to mutagenize Tpl produced alleles that were viable over a chromosome bearing a duplication of Tpl, but were not lethal in combination with a wild-type chromosome, as deficiencies for Tpl are. These mutations were interpreted as hypomorphic alleles of Tpl. In this work, we show that these alleles are not mutations at Tpl; rather, they are dominant mutations in a tightly linked, but cytologically distant, locus that we have named Suppressor-of-Tpl (Su(Tpl)). Su(Tpl) mutations suppress the lethality associated with three copies of the Triplo-lethal locus and are recessive lethal. We have mapped Su(Tpl) to the approximate map position 3-46.5, within the cytological region 76B-76D.
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