The rec8 Gene of Schizosaccharomyces pombe Is Involved in Linear Element Formation, Chromosome Pairing and Sister-Chromatid Cohesion During Meiosis

INVESTIGATIONS

The rec8 Gene of Schizosaccharomyces pombe Is Involved in Linear Element Formation, Chromosome Pairing and Sister-Chromatid Cohesion During Meiosis

M. Molnar, J. Bahler, M. Sipiczki and J. Kohli
Department of Genetics, University of Debrecen, H-4010 Debrecen, Hungary

The fission yeast Schizosaccharomyces pombe does not form tripartite synaptonemal complexes during meiotic prophase, but axial core-like structures (linear elements). To probe the relationship between meiotic recombination and the structure, pairing, and segregation of meiotic chromosomes, we genetically and cytologically characterized the rec8-110 mutant, which is partially deficient in meiotic recombination. The pattern of spore viability indicates that chromosome segregation is affected in the mutant. A detailed segregational analysis in the rec8-110 mutant revealed more spores disomic for chromosome III than in a wild-type strain. Aberrant segregations are caused by precocious segregation of sister chromatids at meiosis I, rather than by nondisjunction as a consequence of lack of crossovers. In situ hybridization further showed that the sister chromatids are separated prematurely during meiotic prophase. Moreover, the mutant forms aberrant linear elements and shows a shortened meiotic prophase. Meiotic chromosome pairing in interstitial and centromeric regions is strongly impaired in rec8-110, whereas the chromosome ends are less deficient in pairing. We propose that the rec8 gene encodes a protein required for linear element formation and that the different phenotypes of rec8-110 reflect direct and indirect consequences of the absence of regular linear elements.

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				C. Ellermeier and G. R. Smith Cohesins are required for meiotic DNA breakage and recombination in Schizosaccharomyces pombe PNAS, August 2, 2005; 102(31): 10952 - 10957. [Abstract] [Full Text] [PDF]

				M. K. Davidson, N. P. Young, G. G. Glick, and W. P. Wahls Meiotic chromosome segregation mutants identified by insertional mutagenesis of fission yeast Schizosaccharomyces pombe; tandem-repeat, single-site integrations Nucleic Acids Res., August 17, 2004; 32(14): 4400 - 4410. [Abstract] [Full Text] [PDF]

				A. Lorenz, J. L. Wells, D. W. Pryce, M. Novatchkova, F. Eisenhaber, R. J. McFarlane, and J. Loidl S. pombe meiotic linear elements contain proteins related to synaptonemal complex components J. Cell Sci., July 1, 2004; 117(15): 3343 - 3351. [Abstract] [Full Text] [PDF]

				B. Liebe, M. Alsheimer, C. Hoog, R. Benavente, and H. Scherthan Telomere Attachment, Meiotic Chromosome Condensation, Pairing, and Bouquet Stage Duration Are Modified in Spermatocytes Lacking Axial Elements Mol. Biol. Cell, February 1, 2004; 15(2): 827 - 837. [Abstract] [Full Text] [PDF]

				R. Mercier, Susan. J. Armstrong, C. Horlow, N. P. Jackson, C. A. Makaroff, D. Vezon, G. Pelletier, G. H. Jones, and F. C. H. Franklin The meiotic protein SWI1 is required for axial element formation and recombination initiation in Arabidopsis Development, July 15, 2003; 130(14): 3309 - 3318. [Abstract] [Full Text] [PDF]

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				M. Molnar, J. Bahler, J. Kohli, and Y. Hiraoka Live observation of fission yeast meiosis in recombination-deficient mutants: a study on achiasmate chromosome segregation J. Cell Sci., January 8, 2001; 114(15): 2843 - 2853. [Abstract] [Full Text] [PDF]

				A. Losada, T. Yokochi, R. Kobayashi, and T. Hirano Identification and Characterization of SA/Scc3p Subunits in the Xenopus and Human Cohesin Complexes J. Cell Biol., August 7, 2000; 150(3): 405 - 416. [Abstract] [Full Text] [PDF]

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