- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Schrick, J. J.
- Articles by Woychik, R. P.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Schrick, J. J.
- Articles by Woychik, R. P.
Genetics, Vol 140, 1061-1067, Copyright © 1995
INVESTIGATIONS |
Molecular and Phenotypic Characterization of a New Mouse Insertional Mutation That Causes a Defect in the Distal Vertebrae of the Spine
J. J. Schrick, M. E. Dickinson, BLM. Hogan, P. B. Selby and R. P. Woychik
University of Tennessee, Graduate School for Biomedical Sciences, Oak Ridge, Tennessee 37831-8080
We have identified and characterized the phenotype of a new insertional mutation in one line of transgenic mice. Mice carrying this mutation, which we have designated TgN(Imusd)370Rpw, display undulations of the vertebrae giving rise to a novel kinky-tail phenotype. Molecular characterization of the insertion site indicates that the transgene integration has occurred without any substantial alterations in the structure of the host sequences. Using probes that flank the insertion site, we have mapped the mutation to chromosome 5 near the semidominant mutation, thick tail (Tht). Thick tail does not complement the TgN(Imusd)370Rpw mutation; compound mutants containing one copy of each mutation display a more severe phenotype than either mutation individually.