- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Dupuis, J.
- Articles by Siegmund, D.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Dupuis, J.
- Articles by Siegmund, D.
Genetics, Vol 140, 843-856, Copyright © 1995
INVESTIGATIONS |
Statistical Methods for Linkage Analysis of Complex Traits from High-Resolution Maps of Identity by Descent
J. Dupuis, P. O. Brown and D. Siegmund
Department of Preventive Medicine and Department of Statistics, Northwestern University, Chicago, Illinois 60611-4402
A multilocus model for complex traits is described that generalizes the additive and multiplicative models and hence allows simultaneously for both heterogeneity and gene interaction (epistasis). Statistical methods of linkage analysis are discussed under the assumption that identity by descent data from a dense set of polymorphic markers are available. Three methods, single locus search, simultaneous search and conditional search, are described and compared.
This article has been cited by other articles:
 |
|
 |
|
  J.-L. Jannink Identifying Quantitative Trait Locus by Genetic Background Interactions in Association Studies Genetics, May 1, 2007; 176(1): 553 - 561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chen and J. D. Storey Relaxed Significance Criteria for Linkage Analysis Genetics, August 1, 2006; 173(4): 2371 - 2381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Bell, C. Wallace, R. Dobson, S. Wiltshire, C. Mein, J. Pembroke, M. Brown, D. Clayton, N. Samani, A. Dominiczak, et al. Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension Hum. Mol. Genet., April 15, 2006; 15(8): 1365 - 1374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Appell Inaugural Article: Biography of David O. Siegmund PNAS, May 25, 2004; 101(21): 7843 - 7844. [Full Text] [PDF]
|
|
|
|
|
|
C. Sabatti, S. Service, and N. Freimer False Discovery Rate in Linkage and Association Genome Screens for Complex Disorders Genetics, June 1, 2003; 164(2): 829 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hoh, A. Wille, and J. Ott Trimming, Weighting, and Grouping SNPs in Human Case-Control Association Studies Genome Res., December 1, 2001; 11(12): 2115 - 2119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Shimomura, S. S. Low-Zeddies, D. P. King, T. D.L. Steeves, A. Whiteley, J. Kushla, P. D. Zemenides, A. Lin, M. H. Vitaterna, G. A. Churchill, et al. Genome-Wide Epistatic Interaction Analysis Reveals Complex Genetic Determinants of Circadian Behavior in Mice Genome Res., June 1, 2001; 11(6): 959 - 980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-C. Shih and A. S Whittemore Allele-sharing among affected relatives: non-parametric methods for identifying genes Statistical Methods in Medical Research, February 1, 2001; 10(1): 27 - 55. [Abstract] [PDF]
|
|
|
|
|
|
J. Dupuis and D. Siegmund Statistical Methods for Mapping Quantitative Trait Loci From a Dense Set of Markers Genetics, January 1, 1999; 151(1): 373 - 386. [Abstract] [Full Text]
|
|