An Autosomal Genetic Linkage Map of the Sheep Genome

INVESTIGATIONS

An Autosomal Genetic Linkage Map of the Sheep Genome

A. M. Crawford, K. G. Dodds, A. J. Ede, C. A. Pierson, G. W. Montgomery, H. G. Garmonsway, A. E. Beattie, K. Davies, J. F. Maddox, S. W. Kappes, R. T. Stone, T. C. Nguyen, J. M. Penty, E. A. Lord, J. E. Broom, J. Buitkamp, W. Schwaiger, J. T. Epplen, P. Matthew, M. E. Matthews, D. J. Hulme, K. J. Beh, R. A. McGraw and C. W. Beattie
AgResearch Molecular Biology Unit, Department of Biochemistry and Centre for Gene Research, University of Otago, Dunedin, New Zealand

We report the first extensive ovine genetic linkage map covering 2070 cM of the sheep genome. The map was generated from the linkage analysis of 246 polymorphic markers, in nine three-generation fullsib pedigrees, which make up the AgResearch International Mapping Flock. We have exploited many markers from cattle so that valuable comparisons between these two ruminant linkage maps can be made. The markers, used in the segregation analyses, comprised 86 anonymous microsatellite markers derived from the sheep genome, 126 anonymous microsatellites from cattle, one from deer, and 33 polymorphic markers of various types associated with known genes. The maximum number of informative meioses within the mapping flock was 222. The average number of informative meioses per marker was 140 (range 18-209). Linkage groups have been assigned to all 26 sheep autosomes.

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				L. Schibler, D. Vaiman, A. Oustry, C. Giraud-Delville, and E. P. Cribiu Comparative Gene Mapping: A Fine-Scale Survey of Chromosome Rearrangements between Ruminants and Humans Genome Res., September 1, 1998; 8(9): 901 - 915. [Abstract] [Full Text]

				G. Lindgren, K. Sandberg, H. Persson, S. Marklund, M. Breen, B. Sandgren, J. Carlstén, and H. Ellegren A Primary Male Autosomal Linkage Map of the Horse Genome Genome Res., September 1, 1998; 8(9): 951 - 966. [Abstract] [Full Text]

				E. Lipkin, M. O. Mosig, A. Darvasi, E. Ezra, A. Shalom, A. Friedmann, and M. Soller Quantitative Trait Locus Mapping in Dairy Cattle by Means of Selective Milk DNA Pooling Using Dinucleotide Microsatellite Markers: Analysis of Milk Protein Percentage Genetics, July 1, 1998; 149(3): 1557 - 1567. [Abstract] [Full Text] [PDF]

				S. Paterson, K. Wilson, and J. M. Pemberton Major histocompatibility complex variation associated with juvenile survival and parasite resistance in a large unmanaged ungulate population (Ovis aries L.) PNAS, March 31, 1998; 95(7): 3714 - 3719. [Abstract] [Full Text] [PDF]

				S M Kappes, J W Keele, R T Stone, R A McGraw, T S Sonstegard, T P Smith, N L Lopez-Corrales, and C W Beattie A second-generation linkage map of the bovine genome. Genome Res., March 1, 1997; 7(3): 235 - 249. [Abstract] [PDF]

				M Georges and L Andersson Livestock genomics comes of age. Genome Res., October 1, 1996; 6(10): 907 - 921. [PDF]

				A M Crawford and R P Cuthbertson Mutations in sheep microsatellites. Genome Res., September 1, 1996; 6(9): 876 - 879. [Abstract] [PDF]

				S M Galloway, V Hanrahan, K G Dodds, M D Potts, A M Crawford, and D F Hill A linkage map of the ovine X chromosome. Genome Res., August 1, 1996; 6(8): 667 - 677. [Abstract] [PDF]

				G A Rohrer, L J Alexander, Z Hu, T P Smith, J W Keele, and C W Beattie A comprehensive map of the porcine genome. Genome Res., May 1, 1996; 6(5): 371 - 391. [Abstract] [PDF]

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				J. F. Maddox, K. P. Davies, A. M. Crawford, D. J. Hulme, D. Vaiman, E. P. Cribiu, B. A. Freking, K. J. Beh, N. E. Cockett, N. Kang, et al. An Enhanced Linkage Map of the Sheep Genome Comprising More Than 1000 Loci Genome Res., July 1, 2001; 11(7): 1275 - 1289. [Abstract] [Full Text] [PDF]