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Genetics, Vol 140, 411-414, Copyright © 1995
INVESTIGATIONS |
Inversions with Deletions and Duplications
AJE. Gordon and J. A. Halliday
Section de Biologie, Institut Curie, 75231 Paris, France
Complex mutational events, including de novo inversion with deletion and duplication of sequence, have been observed but are difficult to model. We propose that nascent leading-strand misalignment upon the lagging-strand template during DNA replication can result in the inversion of sequence. The positioning of this misalignment and of the realignment of the leading strand back onto the leading-strand template will determine if the inversion is accompanied by deletion and duplication of sequence. We suggest that such strand misalignment-realignment events may occur at the replication fork during concurrent DNA replication.
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