- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Fry, J. D.
- Articles by Mackay, TFC.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Fry, J. D.
- Articles by Mackay, TFC.
Genetics, Vol 139, 1293-1307, Copyright © 1995
INVESTIGATIONS |
Polygenic Mutation in Drosophila melanogaster: Genetic Analysis of Selection Lines
J. D. Fry, K. A. deRonde and TFC. Mackay
Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695-7614
We have conducted genetic analyses of 12 long-term selection lines of Drosophila melanogaster derived from a highly inbred base population, containing new mutations affecting abdominal and sternopleural bristle number. Biometric analysis of the number of effective factors differentiating the selected lines from the base inbred indicated that with the exception of the three lines selected for increased number of abdominal bristles, three or more mutations contributed to the responses of the selection lines. Analysis of the chromosomal distribution of effects revealed that mutations affecting abdominal bristle number occurred on all three major chromosomes. In addition, Y-linked mutations with effects ranging from one to three bristles occurred in all three lines selected for decreased number of abdominal bristles, as well as in one line selected for increased abdominal bristle number. Mutations affecting sternopleural bristle number were mainly on the X and third chromosomes. One abdominal and one sternopleural selection line showed evidence of a segregating lethal with large effects on bristle number. As an indirect test for allelism of mutations occurring in different selection lines, the three lines selected in the same direction for the same trait were crossed in all possible combinations, and selection continued from the F(2) hybrids. Responses of the hybrid lines usually did not exceed those of the most extreme parental lines, indicating that the responses of the parental lines may have been partly due to mutations at the same loci, although other interpretations are possible.
This article has been cited by other articles:
 |
|
 |
|
  D. Ostrow, N. Phillips, A. Avalos, D. Blanton, A. Boggs, T. Keller, L. Levy, J. Rosenbloom, and C. F. Baer Mutational Bias for Body Size in Rhabditid Nematodes Genetics, July 1, 2007; 176(3): 1653 - 1661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. F. C. Mackay, R. F. Lyman, and F. Lawrence Polygenic Mutation in Drosophila melanogaster: Mapping Spontaneous Mutations Affecting Sensory Bristle Number Genetics, August 1, 2005; 170(4): 1723 - 1735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. R. Azevedo, P. D. Keightley, C. Lauren-Maatta, L. L. Vassilieva, M. Lynch, and A. M. Leroi Spontaneous Mutational Variation for Body Size in Caenorhabditis elegans Genetics, October 1, 2002; 162(2): 755 - 765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Perez-Gonzalez and T. H. Eickbush Rates of R1 and R2 Retrotransposition and Elimination From the rDNA Locus of Drosophila melanogaster Genetics, October 1, 2002; 162(2): 799 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gadau, R. E. Page, and J. H. Werren The Genetic Basis of the Interspecific Differences in Wing Size in Nasonia (Hymenoptera; Pteromalidae): Major Quantitative Trait Loci and Epistasis Genetics, June 1, 2002; 161(2): 673 - 684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Keightley Genetic Basis of Response to 50 Generations of Selection on Body Weight in Inbred Mice Genetics, April 1, 1998; 148(4): 1931 - 1939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Age-Specific Properties of Spontaneous Mutations Affecting Mortality in Drosophila melanogaster Genetics, January 1, 1998; 148(1): 287 - 304.
|
|