Mapping Quantitative Trait Loci Controlling Milk Production in Dairy Cattle by Exploiting Progeny Testing

INVESTIGATIONS

Mapping Quantitative Trait Loci Controlling Milk Production in Dairy Cattle by Exploiting Progeny Testing

M. Georges, D. Nielsen, M. Mackinnon, A. Mishra, R. Okimoto, A. T. Pasquino, L. S. Sargeant, A. Sorensen, M. R. Steele, X. Zhao, J. E. Womack and I. Hoeschele
Genmark Inc., Salt Lake City, Utah 84108

We have exploited ``progeny testing'' to map quantitative trait loci (QTL) underlying the genetic variation of milk production in a selected dairy cattle population. A total of 1,518 sires, with progeny tests based on the milking performances of > 150,000 daughters jointly, was genotyped for 159 autosomal microsatellites bracketing 1645 centimorgan or approximately two thirds of the bovine genome. Using a maximum likelihood multilocus linkage analysis accounting for variance heterogeneity of the phenotypes, we identified five chromosomes giving very strong evidence (LOD score >/= 3) for the presence of a QTL controlling milk production: chromosomes 1, 6, 9, 10 and 20. These findings demonstrate that loci with considerable effects on milk production are still segregating in highly selected populations and pave the way toward marker-assisted selection in dairy cattle breeding.

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				T. Druet, S. Fritz, M. Boussaha, S. Ben-Jemaa, F. Guillaume, D. Derbala, D. Zelenika, D. Lechner, C. Charon, D. Boichard, et al. Fine Mapping of Quantitative Trait Loci Affecting Female Fertility in Dairy Cattle on BTA03 Using a Dense Single-Nucleotide Polymorphism Map Genetics, April 1, 2008; 178(4): 2227 - 2235. [Abstract] [Full Text] [PDF]

				S. N. White, E. Casas, M. F. Allan, J. W. Keele, W. M. Snelling, T. L. Wheeler, S. D. Shackelford, M. Koohmaraie, and T. P. L. Smith Evaluation in beef cattle of six deoxyribonucleic acid markers developed for dairy traits reveals an osteopontin polymorphism associated with postweaning growth J Anim Sci, January 1, 2007; 85(1): 1 - 10. [Abstract] [Full Text] [PDF]

				T. Druet, S. Fritz, D. Boichard, and J. J. Colleau Estimation of genetic parameters for quantitative trait Loci for dairy traits in the French holstein population. J Dairy Sci, October 1, 2006; 89(10): 4070 - 4076. [Abstract] [Full Text] [PDF]

				S. Viitala, J. Szyda, S. Blott, N. Schulman, M. Lidauer, A. Maki-Tanila, M. Georges, and J. Vilkki The Role of the Bovine Growth Hormone Receptor and Prolactin Receptor Genes in Milk, Fat and Protein Production in Finnish Ayrshire Dairy Cattle Genetics, August 1, 2006; 173(4): 2151 - 2164. [Abstract] [Full Text] [PDF]

				S. H. Lee and J. H. J. Van der Werf Simultaneous Fine Mapping of Multiple Closely Linked Quantitative Trait Loci Using Combined Linkage Disequilibrium and Linkage With a General Pedigree Genetics, August 1, 2006; 173(4): 2329 - 2337. [Abstract] [Full Text] [PDF]

				J. P. Liron, P. Peral-Garcia, and G. Giovambattista Genetic Characterization of Argentine and Bolivian Creole Cattle Breeds Assessed through Microsatellites J. Hered., July 1, 2006; 97(4): 331 - 339. [Abstract] [Full Text] [PDF]

				C. Sandor, F. Farnir, S. Hansoul, W. Coppieters, T. Meuwissen, and M. Georges Linkage Disequilibrium on the Bovine X Chromosome: Characterization and Use in Quantitative Trait Locus Mapping Genetics, July 1, 2006; 173(3): 1777 - 1786. [Abstract] [Full Text] [PDF]

				R. J. Hawken, J. A. L. Cavanagh, J. R. S. Meadows, M. S. Khatkar, Y. Husaini, K. R. Zenger, S. McClintock, A. E. McClintock, and H. W. Raadsma Technical note: Whole-genome amplification of DNA extracted from cattle semen samples. J Dairy Sci, June 1, 2006; 89(6): 2217 - 2221. [Abstract] [Full Text] [PDF]

				M. Gautier, R. R. Barcelona, S. Fritz, C. Grohs, T. Druet, D. Boichard, A. Eggen, and T. H. E. Meuwissen Fine Mapping and Physical Characterization of Two Linked Quantitative Trait Loci Affecting Milk Fat Yield in Dairy Cattle on BTA26 Genetics, January 1, 2006; 172(1): 425 - 436. [Abstract] [Full Text] [PDF]

				M. S. Ashwell, D. W. Heyen, J. I. Weller, M. Ron, T. S. Sonstegard, C. P. Van Tassell, and H. A. Lewin Detection of Quantitative Trait Loci Influencing Conformation Traits and Calving Ease in Holstein-Friesian Cattle J Dairy Sci, November 1, 2005; 88(11): 4111 - 4119. [Abstract] [Full Text] [PDF]

				M. Cohen-Zinder, E. Seroussi, D. M. Larkin, J. J. Loor, A. E.-v. d. Wind, J.-H. Lee, J. K. Drackley, M. R. Band, A.G. Hernandez, M. Shani, et al. Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle Genome Res., July 1, 2005; 15(7): 936 - 944. [Abstract] [Full Text] [PDF]

				C. Mantey, G. A. Brockmann, E. Kalm, and N. Reinsch Mapping and Exclusion Mapping of Genomic Imprinting Effects in Mouse F2 Families J. Hered., July 1, 2005; 96(4): 329 - 338. [Abstract] [Full Text] [PDF]

				R. D. Schnabel, J.-J. Kim, M. S. Ashwell, T. S. Sonstegard, C. P. Van Tassell, E. E. Connor, and J. F. Taylor Fine-mapping milk production quantitative trait loci on BTA6: Analysis of the bovine osteopontin gene PNAS, May 10, 2005; 102(19): 6896 - 6901. [Abstract] [Full Text] [PDF]

				C. Schrooten, H. Bovenhuis, J. A. M. van Arendonk, and P. Bijma Genetic Progress in Multistage Dairy Cattle Breeding Schemes Using Genetic Markers J Dairy Sci, April 1, 2005; 88(4): 1569 - 1581. [Abstract] [Full Text] [PDF]

				R. Weikard, C. Kuhn, T. Goldammer, G. Freyer, and M. Schwerin The bovine PPARGC1A gene: molecular characterization and association of an SNP with variation of milk fat synthesis Physiol Genomics, March 21, 2005; 21(1): 1 - 13. [Abstract] [Full Text] [PDF]

				J. Szyda, Z. Liu, F. Reinhardt, and R. Reents Estimation of Quantitative Trait Loci Parameters for Milk Production Traits in German Holstein Dairy Cattle Population J Dairy Sci, January 1, 2005; 88(1): 356 - 367. [Abstract] [Full Text] [PDF]

				H. G. Olsen, S. Lien, M. Gautier, H. Nilsen, A. Roseth, P. R. Berg, K. K. Sundsaasen, M. Svendsen, and T. H. E. Meuwissen Mapping of a Milk Production Quantitative Trait Locus to a 420-kb Region on Bovine Chromosome 6 Genetics, January 1, 2005; 169(1): 275 - 283. [Abstract] [Full Text] [PDF]

				C. Schrooten, M. C. A. M. Bink, and H. Bovenhuis Whole Genome Scan to Detect Chromosomal Regions Affecting Multiple Traits in Dairy Cattle J Dairy Sci, October 1, 2004; 87(10): 3550 - 3560. [Abstract] [Full Text] [PDF]

				M. Holmberg and L. Andersson-Eklund Quantitative Trait Loci Affecting Health Traits in Swedish Dairy Cattle J Dairy Sci, August 1, 2004; 87(8): 2653 - 2659. [Abstract] [Full Text] [PDF]

				G. A. Walling, P. M. Visscher, A. D. Wilson, B. L. McTeir, G. Simm, and S. C. Bishop Mapping of quantitative trait loci for growth and carcass traits in commercial sheep populations J Anim Sci, August 1, 2004; 82(8): 2234 - 2245. [Abstract] [Full Text] [PDF]

				C. Zhang, D.-J. de Koning, J. Hernandez-Sanchez, C. S. Haley, J. L. Williams, and P. Wiener Mapping of Multiple Quantitative Trait Loci Affecting Bovine Spongiform Encephalopathy Genetics, August 1, 2004; 167(4): 1863 - 1872. [Abstract] [Full Text] [PDF]

				H. G. Olsen, S. Lien, M. Svendsen, H. Nilsen, A. Roseth, M. Aasland Opsal, and T. H. E. Meuwissen Fine Mapping of Milk Production QTL on BTA6 by Combined Linkage and Linkage Disequilibrium Analysis J Dairy Sci, March 1, 2004; 87(3): 690 - 698. [Abstract] [Full Text] [PDF]

				J. Nsengimana, P. Baret, C. S. Haley, and P. M. Visscher Linkage Disequilibrium in the Domesticated Pig Genetics, March 1, 2004; 166(3): 1395 - 1404. [Abstract] [Full Text] [PDF]

				N. F. Schulman, S. M. Viitala, D. J. de Koning, J. Virta, A. Maki-Tanila, and J. H. Vilkki Quantitative Trait Loci for Health Traits in Finnish Ayrshire Cattle J Dairy Sci, February 1, 2004; 87(2): 443 - 449. [Abstract] [Full Text] [PDF]

				M. S. Ashwell, D. W. Heyen, T. S. Sonstegard, C. P. Van Tassell, Y. Da, P. M. VanRaden, M. Ron, J. I. Weller, and H. A. Lewin Detection of Quantitative Trait Loci Affecting Milk Production, Health, and Reproductive Traits in Holstein Cattle J Dairy Sci, February 1, 2004; 87(2): 468 - 475. [Abstract] [Full Text] [PDF]

				M. Ron, E. Feldmesser, M. Golik, I. Tager-Cohen, D. Kliger, V. Reiss, R. Domochovsky, O. Alus, E. Seroussi, E. Ezra, et al. A Complete Genome Scan of the Israeli Holstein Population for Quantitative Trait Loci by a Daughter Design J Dairy Sci, February 1, 2004; 87(2): 476 - 490. [Abstract] [Full Text] [PDF]

				Y. Liu, G. B. Jansen, and C. Y. Lin Quantitative Trait Loci Mapping for Dairy Cattle Production Traits Using a Maximum Likelihood Method J Dairy Sci, February 1, 2004; 87(2): 491 - 500. [Abstract] [Full Text] [PDF]

				R. Mihaljevic, H. F. Utz, and A. E. Melchinger Congruency of Quantitative Trait Loci Detected for Agronomic Traits in Testcrosses of Five Populations of European Maize Crop Sci., January 1, 2004; 44(1): 114 - 124. [Abstract] [Full Text] [PDF]

				A. Stella and P. J. Boettcher Optimal Designs for Linkage Disequilibrium Mapping and Candidate Gene Association Tests in Livestock Populations Genetics, January 1, 2004; 166(1): 341 - 350. [Abstract] [Full Text] [PDF]