- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Mackay, TFC.
- Articles by Hill, W. G.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Mackay, TFC.
- Articles by Hill, W. G.
Genetics, Vol 139, 849-859, Copyright © 1995
INVESTIGATIONS |
Polygenic Mutation in Drosophila melanogaster: Non-Linear Divergence Among Unselected Strains
TFC. Mackay, R. F. Lyman and W. G. Hill
Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695-7614
A highly inbred strain of Drosophila melanogaster was subdivided into 20 replicate sublines that were maintained independently with 10 pairs of randomly sampled parents per generation for 180 generations. The variance between lines in abdominal and sternopleural bristle number increased little after 100 generations, in contrast to the neutral expectation of a linear increase; and the covariances of line means between different generations declined with increasing number of generations apart, in contrast to the neutral expectation of constant covariance. Thus, under a neutral model, the estimates of mutational variance were lower than for previous estimates from the first 100 generations of subline divergence. An autoregressive model was fitted to the variance of line means that indicated strong natural selection. There is no single unequivocal explanation for the results. Possible and nonexclusive alternatives include stabilizing selection on bristle number and deleterious effects on fitness of bristle mutations. The inferred strengths of selection on both traits are too high for stabilizing selection alone, and the between-line variance did not continue to increase sufficiently for pleiotropy alone to account for the observations. A third potential explanation that does not invoke selection is duplicate epistasis between mutations affecting bristle number.
This article has been cited by other articles:
 |
|
 |
|
  T. F. C. Mackay, R. F. Lyman, and F. Lawrence Polygenic Mutation in Drosophila melanogaster: Mapping Spontaneous Mutations Affecting Sensory Bristle Number Genetics, August 1, 2005; 170(4): 1723 - 1735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Weinig, L. A. Dorn, N. C. Kane, Z. M. German, S. S. Halldorsdottir, M. C. Ungerer, Y. Toyonaga, T. F. C. Mackay, M. D. Purugganan, and J. Schmitt Heterogeneous Selection at Specific Loci in Natural Environments in Arabidopsis thaliana Genetics, September 1, 2003; 165(1): 321 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Dilda and T. F. C. Mackay The Genetic Architecture of Drosophila Sensory Bristle Number Genetics, December 1, 2002; 162(4): 1655 - 1674. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Pletcher, D. Houle, and J. W. Curtsinger The Evolution of Age-Specific Mortality Rates in Drosophila melanogaster: Genetic Divergence Among Unselected Lines Genetics, October 1, 1999; 153(2): 813 - 823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Gurganus, S. V. Nuzhdin, J. W. Leips, and T. F. C. Mackay High-Resolution Mapping of Quantitative Trait Loci for Sternopleural Bristle Number in Drosophila melanogaster Genetics, August 1, 1999; 152(4): 1585 - 1604. [Abstract] [Full Text]
|
|
|
|
|
|
M. C. Gurganus, J. D. Fry, S. V. Nuzhdin, E. G. Pasyukova, R. F. Lyman, and T. F. C. Mackay Genotype-Environment Interaction at Quantitative Trait Loci Affecting Sensory Bristle Number in Drosophila melanogaster Genetics, August 1, 1998; 149(4): 1883 - 1898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. F. Lyman and T. F. C. Mackay Candidate Quantitative Trait Loci and Naturally Occurring Phenotypic Variation for Bristle Number in Drosophila melanogaster: The Delta-Hairless Gene Region Genetics, June 1, 1998; 149(2): 983 - 998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Quantitative Genetics of Ovariole Number in Drosophila melanogaster. II. Mutational Variation and Genotype-Environment Interaction Genetics, January 1, 1998; 148(1): 201 - 210.
|
|
|
|
 |
|
 S. V. Nuzhdin, E. G. Pasyukova, C. L. Dilda, Z.-B. Zeng, and T. F. C. Mackay Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster PNAS, September 2, 1997; 94(18): 9734 - 9739. [Abstract] [Full Text] [PDF]
|
|