Sex-Limited Mitochondrial DNA Transmission in the Marine Mussel Mytilus edulis

INVESTIGATIONS

Sex-Limited Mitochondrial DNA Transmission in the Marine Mussel Mytilus edulis

DOF. Skibinski, C. Gallagher and C. M. Beynon
Molecular Biology Research Group, School of Biological Sciences, University of Wales, Swansea SA2 8PP, United Kingdom

Mitochondrial DNA (mtDNA) was thought to be inherited maternally in animals, although paternal leakage has been reported in mice and Drosophila. Recently, direct evidence of extensive paternal inheritance of mtDNA has been found in the marine mussel Mytilus. We give evidence that whereas female mussels are homoplasmic for a genome that is transmitted to eggs, male mussels are heteroplasmic for this genome and for a second genome that is transmitted preferentially to sperm. The results provide support for the existence of separate male and female routes of mtDNA inheritance in mussels. The two genomes show a base sequence divergence exceeding 20% at three protein coding genes, consistent with long term maintenance of the heteroplasmic state. We propose that the two genomes differ in fitness in males and females, possibly as a result of interaction with nuclear genes.

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				M. Passamonti, J. L. Boore, and V. Scali Molecular Evolution and Recombination in Gender-Associated Mitochondrial DNAs of the Manila Clam Tapes philippinarum Genetics, June 1, 2003; 164(2): 603 - 611. [Abstract] [Full Text] [PDF]

				E. Kenchington, B. MacDonald, L. Cao, D. Tsagkarakis, and E. Zouros Genetics of Mother-Dependent Sex Ratio in Blue Mussels (Mytilus spp.) and Implications for Doubly Uniparental Inheritance of Mitochondrial DNA Genetics, August 1, 2002; 161(4): 1579 - 1588. [Abstract] [Full Text] [PDF]

				J. P. Curole and T. D. Kocher Ancient Sex-Specific Extension of the Cytochrome c Oxidase II Gene in Bivalves and the Fidelity of Doubly-Uniparental Inheritance Mol. Biol. Evol., August 1, 2002; 19(8): 1323 - 1328. [Abstract] [Full Text] [PDF]

				J. G. Umen and U. W. Goodenough Chloroplast DNA methylation and inheritance in Chlamydomonas Genes & Dev., October 1, 2001; 15(19): 2585 - 2597. [Abstract] [Full Text] [PDF]

				E. D. Ladoukakis and E. Zouros Direct Evidence for Homologous Recombination in Mussel (Mytilus galloprovincialis) Mitochondrial DNA Mol. Biol. Evol., July 1, 2001; 18(7): 1168 - 1175. [Abstract] [Full Text] [PDF]

				A. E. Bogan and W. R. Hoeh On becoming cemented: evolutionary relationships among the genera in the freshwater bivalve family Etheriidae (Bivalvia: Unionoida) Geological Society, London, Special Publications, January 1, 2000; 177(1): 159 - 168. [Abstract] [PDF]

				C. T. Beagley, R. Okimoto, and D. R. Wolstenholme Mytilus Mitochondrial DNA Contains a Functional Gene for a tRNASer(UCN) With a Dihydrouridine Arm-Replacement Loop and a pseudo-tRNASer(UCN) Gene Genetics, June 1, 1999; 152(2): 641 - 652. [Abstract] [Full Text]

				L. Partridge and Laurence D. Hurst Sex and Conflict Science, September 25, 1998; 281(5385): 2003 - 2008. [Abstract] [Full Text]

				H. Quesada, M. Warren, and D. O. F. Skibinski Nonneutral Evolution and Differential Mutation Rate of Gender-Associated Mitochondrial DNA Lineages in the Marine Mussel Mytilus Genetics, July 1, 1998; 149(3): 1511 - 1526. [Abstract] [Full Text] [PDF]

				The Fate of Paternal Mitochondrial DNA in Developing Female Mussels, Mytilus edulis: Implications for the Mechanism of Doubly Uniparental Inheritance of Mitochondrial DNA Genetics, January 1, 1998; 148(1): 341 - 348.