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Genetics, Vol 138, 721-732, Copyright © 1994
INVESTIGATIONS |
Dosage Compensation of the period Gene in Drosophila melanogaster
M. K. Cooper, M. J. Hamblen-Coyle, X. Liu, J. E. Rutila and J. C. Hall
Department of Biology, Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02254 Current address: Department of Neurology, Johns Hopkins University, 600 North Wolfe Street, Baltimore, Maryland 21287-7609.
The period (per) gene is located on the X chromosome of Drosophila melanogaster. Its expression influences biological clocks in this fruit fly, including the one that subserves circadian rhythms of locomotor activity. Like most X-linked genes in Drosophila, per is under the regulatory control of gene dosage compensation. In this study, we assessed the activity of altered or augmented per(+) DNA fragments in transformants. Relative expression levels in male and female adults were inferred from periodicities associated with locomotor behavioral rhythms, and by histochemically assessing {beta}-galactosidase levels in transgenics carrying different kinds of per-lacZ fusion genes. The results suggest that per contains multipartite regulatory information for dosage compensation within the large first intron and also within the 3' half of this genetic locus.
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