- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Cramton, S. E.
- Articles by Laski, F. A.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Cramton, S. E.
- Articles by Laski, F. A.
Genetics, Vol 137, 1039-1048, Copyright © 1994
INVESTIGATIONS |
string of pearls Encodes Drosophila Ribosomal Protein S2, Has Minute-Like Characteristics, and Is Required During Oogenesis
S. E. Cramton and F. A. Laski
Molecular Biology Institute, Department of Biology, University of California, Los Angeles, Los Angeles, California 90024
The first allele of string of pearls (sop) was isolated as a recessive female sterile mutant in a P element enhancer trap screen. Oogenesis in homozygous sop females arrests at approximately stage 5. In addition, homozygous flies of both sexes have Minute-like characteristics that include reduced bristles, delayed development and larval lethality. sop maps to 30D/E on chromosome 2L and encodes the Drosophila homolog of eukaryotic ribosomal protein S2. The gene is present in a single copy in the Drosophila genome and the level of mRNA present in mutant animals is reduced. The identification of a mutant allele that blocks development at a mid-stage of oogenesis may indicate that sop has a specific developmental role during oogenesis in addition to its general role in protein synthesis as a component of the small ribosomal subunit.
This article has been cited by other articles:
 |
|
 |
|
  J. Emmons, W.H. D. Townley-Tilson, K. M. Deleault, S. J. Skinner, R. H. Gross, M. L. Whitfield, and S. A. Brooks Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation RNA, May 1, 2008; 14(5): 888 - 902. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Swiercz, D. Cheng, D. Kim, and M. T. Bedford Ribosomal Protein rpS2 Is Hypomethylated in PRMT3-deficient Mice J. Biol. Chem., June 8, 2007; 282(23): 16917 - 16923. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Cui and P. J. DiMario RNAi Knockdown of Nopp140 Induces Minute-like Phenotypes in Drosophila Mol. Biol. Cell, June 1, 2007; 18(6): 2179 - 2191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Deutschbauer, D. F. Jaramillo, M. Proctor, J. Kumm, M. E. Hillenmeyer, R. W. Davis, C. Nislow, and G. Giaever Mechanisms of Haploinsufficiency Revealed by Genome-Wide Profiling in Yeast Genetics, April 1, 2005; 169(4): 1915 - 1925. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Matsson, E. J. Davey, N. Draptchinskaia, I. Hamaguchi, A. Ooka, P. Leveen, E. Forsberg, S. Karlsson, and N. Dahl Targeted Disruption of the Ribosomal Protein S19 Gene Is Lethal Prior to Implantation Mol. Cell. Biol., May 1, 2004; 24(9): 4032 - 4037. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. D'Andrea, N. Dahl, E. C. Guinan, and A. Shimamura Marrow Failure Hematology, January 1, 2002; 2002(1): 58 - 72. [Abstract] [Full Text]
|
|
|
|
|
|
A. M. Volpe, H. Horowitz, C. M. Grafer, S. M. Jackson, and C. A. Berg Drosophila rhino Encodes a Female-Specific Chromo-domain Protein That Affects Chromosome Structure and Egg Polarity Genetics, November 1, 2001; 159(3): 1117 - 1134. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Chrast, H. S. Scott, M. P. Papasavvas, C. Rossier, E. S. Antonarakis, C. Barras, M. T. Davisson, C. Schmidt, X. Estivill, M. Dierssen, et al. The Mouse Brain Transcriptome by SAGE: Differences in Gene Expression between P30 Brains of the Partial Trisomy 16 Mouse Model of Down Syndrome (Ts65Dn) and Normals Genome Res., December 1, 2000; 10(12): 2006 - 2021. [Abstract] [Full Text]
|
|
|
|
|
|
I. Torok, D. Herrmann-Horle, I. Kiss, G. Tick, G. Speer, R. Schmitt, and B. M. Mechler Down-Regulation of RpS21, a Putative Translation Initiation Factor Interacting with P40, Produces Viable Minute Imagos and Larval Lethality with Overgrown Hematopoietic Organs and Imaginal Discs Mol. Cell. Biol., March 1, 1999; 19(3): 2308 - 2321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Naora, I. Takai, M. Adachi, and H. Naora Altered Cellular Responses by Varying Expression of a Ribosomal Protein Gene: Sequential Coordination of Enhancement and Suppression of Ribosomal Protein S3a Gene Expression Induces Apoptosis J. Cell Biol., May 4, 1998; 141(3): 741 - 753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kenmochi, T. Kawaguchi, S. Rozen, E. Davis, N. Goodman, T. J. Hudson, T. Tanaka, and D. C. Page A Map of 75 Human Ribosomal Protein Genes Genome Res., May 1, 1998; 8(5): 509 - 523. [Abstract] [Full Text]
|
|
|
|
|
|
L. Davis and J. Engebrecht Yeast dom34 Mutants Are Defective in Multiple Developmental Pathways and Exhibit Decreased Levels of Polyribosomes Genetics, May 1, 1998; 149(1): 45 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Saboe-Larssen, M. Lyamouri, J. Merriam, M. P. Oksvold, and A. Lambertsson Ribosomal Protein Insufficiency and the Minute Syndrome in Drosophila: A Dose-Response Relationship Genetics, March 1, 1998; 148(3): 1215 - 1224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Keyes and A. Spradling The Drosophila gene fs(2)cup interacts with otu to define a cytoplasmic pathway required for the structure and function of germ-line chromosomes Development, January 4, 1997; 124(7): 1419 - 1431. [Abstract] [PDF]
|
|