- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Sall, T.
- Articles by Nilsson, N. O.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Sall, T.
- Articles by Nilsson, N. O.
Genetics, Vol 137, 589-596, Copyright © 1994
INVESTIGATIONS |
The Robustness of Recombination Frequency Estimates in Intercrosses With Dominant Markers
T. Sall and N. O. Nilsson
Department of Genetics, Lund University, S-223 62 Lund, Sweden
The robustness of the maximum likelihood estimates of recombination frequencies has been investigated in double intercrosses with complete dominance at both loci. The robustness was investigated with respect to bias in the recombination frequency estimates due to: (1) limited sample sizes, (2) heterogeneity in recombination frequencies between sexes or among meioses and (3) factors that distort the segregation-misclassification or differential viability. In the coupling phase, the recombination frequency estimates are quite robust with respect to most of the investigated factors. Potentially, the most serious cause of a bias is misclassifications, which tend to increase the recombination frequency estimates. In the repulsion phase, misclassifications are particularly serious, leading to extreme discrepancies between true and observed values. In addition, limited sample size and sex differences in recombination can also bias recombination frequency estimates in repulsion. These effects may pose serious problem in genetic mapping with random amplified polymorphic DNA (RAPD) markers.
This article has been cited by other articles:
 |
|
 |
|
  M.-T. Cervera, V. Storme, B. Ivens, J. Gusmao, B. H. Liu, V. Hostyn, J. Van Slycken, M. Van Montagu, and W. Boerjan Dense Genetic Linkage Maps of Three Populus Species (Populus deltoides, P. nigra and P. trichocarpa) Based on AFLP and Microsatellite Markers Genetics, June 1, 2001; 158(2): 787 - 809. [Abstract] [Full Text] [PDF]
|
|