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Genetics, Vol 137, 513-520, Copyright © 1994
INVESTIGATIONS |
A Drosophila Third Chromosome Minute Locus Encodes a Ribosomal Protein
S. Andersson, S. S{aelig}b{oslash}e-Larssen, A. Lambertsson, J. Merriam and M. Jacobs-Lorena
Department of Genetics, University of Umea, S-901 87 Umea, Sweden
Minutes (M) are a group of over 50 phenotypically similar Drosophila mutations widely believed to affect ribosomal protein genes. This report describes the characterization of the P element-induced M(3)95A(Plac92) mutation [allelic to M(3)95A]. This mutation can be reversed by the mobilization of the P element, demonstrating that the mutation is caused by insertion of this transposable element. The gene interrupted by insertion of the P element was cloned by use of inverse polymerase chain reaction. Nucleotide sequence analysis revealed a 70-75% identity to the human and rat ribosomal protein S3 genes, and to the Xenopus ribosomal protein S1a gene. At the amino acid level, the overall identity is {complex}78% for all three species. This is only the second time that a Minute has been demonstrated to encode a ribosomal protein.
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