- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Orr, H. A.
- Articles by Otto, S. P.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Orr, H. A.
- Articles by Otto, S. P.
Genetics, Vol 136, 1475-1480, Copyright © 1994
INVESTIGATIONS |
Does Diploidy Increase the Rate of Adaptation?
H. A. Orr and S. P. Otto
Department of Biology, University of Rochester, Rochester, New York 14627
Explanations of the evolution of diploidy have focused on the advantages gained from masking deleterious alleles. Recent theory has shown, however, that masking does not always provide an advantage to diploidy and would never favor diploidy in predominantly asexual organisms. We explore a neglected alternative theory which posits that, by doubling the genome size, diploids double the rate at which favorable mutations arise. Consequently, the rate of adaptation in diploids is presumed to be faster than in haploids. The rate of adaptation, however, depends not only on the rate of appearance of new favorable mutations but also on the rate at which these mutations are incorporated (which depends on the population size and on the dominance of favorable mutations). We show that, in both asexuals and sexuals, doubling the mutation rate via diploidy often does not accelerate the rate of adaptation. Indeed, under many conditions, diploidy slows adaptation.
This article has been cited by other articles:
 |
|
 |
|
  C. McBryde, J. M. Gardner, M. de Barros Lopes, and V. Jiranek Generation of Novel Wine Yeast Strains by Adaptive Evolution Am. J. Enol. Vitic., December 1, 2006; 57(4): 423 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Veitia Paralogs in Polyploids: One for All and All for One? PLANT CELL, January 1, 2005; 17(1): 4 - 11. [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Anderson, C. Sirjusingh, and N. Ricker Haploidy, Diploidy and Evolution of Antifungal Drug Resistance in Saccharomyces cerevisiae Genetics, December 1, 2004; 168(4): 1915 - 1923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Froissart, C. O. Wilke, R. Montville, S. K. Remold, L. Chao, and P. E. Turner Co-infection Weakens Selection Against Epistatic Mutations in RNA Viruses Genetics, September 1, 2004; 168(1): 9 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Nuismer and S. P. Otto Host-parasite interactions and the evolution of ploidy PNAS, July 27, 2004; 101(30): 11036 - 11039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Otto The Advantages of Segregation and the Evolution of Sex Genetics, July 1, 2003; 164(3): 1099 - 1118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Anderson, C. Sirjusingh, A. B. Parsons, C. Boone, C. Wickens, L. E. Cowen, and L. M. Kohn Mode of Selection and Experimental Evolution of Antifungal Drug Resistance in Saccharomyces cerevisiae Genetics, April 1, 2003; 163(4): 1287 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Zeyl, T. Vanderford, and M. Carter An Evolutionary Advantage of Haploidy in Large Yeast Populations Science, January 24, 2003; 299(5606): 555 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Hall The Evolution of Haploid, Diploid and Polymorphic Haploid-Diploid Life Cycles: The Role of Meiotic Mutation Genetics, October 1, 2000; 156(2): 893 - 898. [Abstract] [Full Text]
|
|