Evidence for Positive Selection in the Superoxide Dismutase (Sod) Region of Drosophila melanogaster

INVESTIGATIONS

Evidence for Positive Selection in the Superoxide Dismutase (Sod) Region of Drosophila melanogaster

R. R. Hudson, K. Bailey, D. Skarecky, J. Kwiatowski and F. J. Ayala
Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92717

DNA sequence variation in a 1410-bp region including the Cu,Zn Sod locus was examined in 41 homozygous lines of Drosophila melanogaster. Fourteen lines were from Barcelona, Spain, 25 were from California populations and the other two were from laboratory stocks. Two common electromorphs, SOD(S) and SOD(F), are segregating in the populations. Our sample of 41 lines included 19 Sod(S) and 22 Sod(F) alleles (henceforward referred to as Slow and Fast alleles). All 19 Slow alleles were identical in sequence. Of the 22 Fast alleles sequenced, nine were identical in sequence and are referred to as the Fast A haplotypes. The Slow allele sequence differed from the Fast A haplotype at a single nucleotide site, the site that accounts for the amino acid difference between SOD(S) and SOD(F). There were nine other haplotypes among the remaining 13 Fast alleles sequenced. The overall level of nucleotide diversity ({pi}) in this sample is not greatly different than that found at other loci in D. melanogaster. It is concluded that the Slow/Fast polymorphism is a recently arisen polymorphism, not an old balanced polymorphism. The large group of nearly identical haplotypes suggests that a recent mutation, at the Sod locus or tightly linked to it, has increased rapidly in frequency to around 50%, both in California and Spain. The application of a new statistical test demonstrates that the occurrence of such large numbers of haplotypes with so little variation among them is very unlikely under the usual equilibrium neutral model. We suggest that the high frequency of some haplotypes is due to natural selection at the Sod locus or at a tightly linked locus.

This article has been cited by other articles:

J. F. Storz and J. K. Kelly
Effects of Spatially Varying Selection on Nucleotide Diversity and Linkage Disequilibrium: Insights From Deer Mouse Globin Genes
Genetics, September 1, 2008; 180(1): 367 - 379.
[Abstract] [Full Text] [PDF]

N. A. Rosenberg and M. Jakobsson
The Relationship Between Homozygosity and the Frequency of the Most Frequent Allele
Genetics, August 1, 2008; 179(4): 2027 - 2036.
[Abstract] [Full Text] [PDF]

C.-L. Huang, S.-Y. Hwang, Y.-C. Chiang, and T.-P. Lin
Molecular Evolution of the Pi-ta Gene Resistant to Rice Blast in Wild Rice (Oryza rufipogon)
Genetics, July 1, 2008; 179(3): 1527 - 1538.
[Abstract] [Full Text] [PDF]

P. Pfaffelhuber, A. Lehnert, and W. Stephan
Linkage Disequilibrium Under Genetic Hitchhiking in Finite Populations
Genetics, May 1, 2008; 179(1): 527 - 537.
[Abstract] [Full Text] [PDF]

N. Derome, E. Baudry, D. Ogereau, M. Veuille, and C. Montchamp-Moreau
Selective Sweeps in a 2-Locus Model for Sex-Ratio Meiotic Drive in Drosophila simulans
Mol. Biol. Evol., February 1, 2008; 25(2): 409 - 416.
[Abstract] [Full Text] [PDF]

A. L. Evans, P. A. Mena, and B. F. McAllister
Positive Selection Near an Inversion Breakpoint on the Neo-X Chromosome of Drosophila americana
Genetics, November 1, 2007; 177(3): 1303 - 1319.
[Abstract] [Full Text] [PDF]

K. Zeng, S. Mano, S. Shi, and C.-I Wu
Comparisons of Site- and Haplotype-Frequency Methods for Detecting Positive Selection
Mol. Biol. Evol., July 1, 2007; 24(7): 1562 - 1574.
[Abstract] [Full Text] [PDF]

E. Tauber, M. Zordan, F. Sandrelli, M. Pegoraro, N. Osterwalder, C. Breda, A. Daga, A. Selmin, K. Monger, C. Benna, et al.
Natural Selection Favors a Newly Derived timeless Allele in Drosophila melanogaster
Science, June 29, 2007; 316(5833): 1895 - 1898.
[Abstract] [Full Text] [PDF]

A. Sanchez-Gracia and J. Rozas
Unusual Pattern of Nucleotide Sequence Variation at the OS-E and OS-F Genomic Regions of Drosophila simulans
Genetics, April 1, 2007; 175(4): 1923 - 1935.
[Abstract] [Full Text] [PDF]

G. McVean
The Structure of Linkage Disequilibrium Around a Selective Sweep
Genetics, March 1, 2007; 175(3): 1395 - 1406.
[Abstract] [Full Text] [PDF]

S. Seixas, G. Suriano, F. Carvalho, R. Seruca, J. Rocha, and A. Di Rienzo
Sequence Diversity at the Proximal 14q32.1 SERPIN Subcluster: Evidence for Natural Selection Favoring the Pseudogenization of SERPINA2
Mol. Biol. Evol., February 1, 2007; 24(2): 587 - 598.
[Abstract] [Full Text] [PDF]

K. Zeng, Y.-X. Fu, S. Shi, and C.-I Wu
Statistical Tests for Detecting Positive Selection by Utilizing High-Frequency Variants
Genetics, November 1, 2006; 174(3): 1431 - 1439.
[Abstract] [Full Text] [PDF]

H. Innan
Modified Hudson-Kreitman-Aguade Test and Two-Dimensional Evaluation of Neutrality Tests
Genetics, July 1, 2006; 173(3): 1725 - 1733.
[Abstract] [Full Text] [PDF]

P. C. Sabeti, S. F. Schaffner, B. Fry, J. Lohmueller, P. Varilly, O. Shamovsky, A. Palma, T. S. Mikkelsen, D. Altshuler, and E. S. Lander
Positive natural selection in the human lineage.
Science, June 16, 2006; 312(5780): 1614 - 1620.
[Abstract] [Full Text] [PDF]

S. Beisswanger, W. Stephan, and D. De Lorenzo
Evidence for a Selective Sweep in the wapl Region of Drosophila melanogaster
Genetics, January 1, 2006; 172(1): 265 - 274.
[Abstract] [Full Text] [PDF]

M. Soejima, H. Tachida, T. Ishida, A. Sano, and Y. Koda
Evidence for Recent Positive Selection at the Human AIM1 Locus in a European Population
Mol. Biol. Evol., January 1, 2006; 23(1): 179 - 188.
[Abstract] [Full Text] [PDF]

M. A. Saunders, M. Slatkin, C. Garner, M. F. Hammer, and M. W. Nachman
The Extent of Linkage Disequilibrium Caused by Selection on G6PD in Humans
Genetics, November 1, 2005; 171(3): 1219 - 1229.
[Abstract] [Full Text] [PDF]

C. S. Lim, L. Tazi, and F. J. Ayala
Plasmodium vivax: Recent world expansion and genetic identity to Plasmodium simium
PNAS, October 25, 2005; 102(43): 15523 - 15528.
[Abstract] [Full Text] [PDF]

P. K. Ingvarsson
Molecular Population Genetics of Herbivore-induced Protease Inhibitor Genes in European Aspen (Populus tremula L., Salicaceae)
Mol. Biol. Evol., September 1, 2005; 22(9): 1802 - 1812.
[Abstract] [Full Text] [PDF]

P. R. Haddrill, K. R. Thornton, B. Charlesworth, and P. Andolfatto
Multilocus patterns of nucleotide variability and the demographic and selection history of Drosophila melanogaster populations
Genome Res., June 1, 2005; 15(6): 790 - 799.
[Abstract] [Full Text] [PDF]

H. Innan, K. Zhang, P. Marjoram, S. Tavare, and N. A. Rosenberg
Statistical Tests of the Coalescent Model Based on the Haplotype Frequency Distribution and the Number of Segregating Sites
Genetics, March 1, 2005; 169(3): 1763 - 1777.
[Abstract] [Full Text] [PDF]

S. J. Macdonald and A. D. Long
Identifying Signatures of Selection at the Enhancer of split Neurogenic Gene Complex in Drosophila
Mol. Biol. Evol., March 1, 2005; 22(3): 607 - 619.
[Abstract] [Full Text] [PDF]

F. Catania and C. Schlotterer
Non-African Origin of a Local Beneficial Mutation in D. melanogaster
Mol. Biol. Evol., February 1, 2005; 22(2): 265 - 272.
[Abstract] [Full Text] [PDF]

J. E. Stajich and M. W. Hahn
Disentangling the Effects of Demography and Selection in Human History
Mol. Biol. Evol., January 1, 2005; 22(1): 63 - 73.
[Abstract] [Full Text] [PDF]

K. K. Shimizu, J. M. Cork, A. L. Caicedo, C. A. Mays, R. C. Moore, K. M. Olsen, S. Ruzsa, G. Coop, C. D. Bustamante, P. Awadalla, et al.
Darwinian Selection on a Selfing Locus
Science, December 17, 2004; 306(5704): 2081 - 2084.
[Abstract] [Full Text] [PDF]

M. C. Leclerc, P. Durand, C. Gauthier, S. Patot, N. Billotte, M. Menegon, C. Severini, F. J. Ayala, and F. Renaud
From The Cover: Meager genetic variability of the human malaria agent Plasmodium vivax
PNAS, October 5, 2004; 101(40): 14455 - 14460.
[Abstract] [Full Text] [PDF]

E. Sezgin, D. D. Duvernell, L. M. Matzkin, Y. Duan, C.-T. Zhu, B. C. Verrelli, and W. F. Eanes
Single-Locus Latitudinal Clines and Their Relationship to Temperate Adaptation in Metabolic Genes and Derived Alleles in Drosophila melanogaster
Genetics, October 1, 2004; 168(2): 923 - 931.
[Abstract] [Full Text] [PDF]

C. D. Meiklejohn, Y. Kim, D. L. Hartl, and J. Parsch
Identification of a Locus Under Complex Positive Selection in Drosophila simulans by Haplotype Mapping and Composite-Likelihood Estimation
Genetics, September 1, 2004; 168(1): 265 - 279.
[Abstract] [Full Text] [PDF]

E. S. Balakirev and F. J. Ayala
Nucleotide Variation in the tinman and bagpipe Homeobox Genes of Drosophila melanogaster
Genetics, April 1, 2004; 166(4): 1845 - 1856.
[Abstract] [Full Text] [PDF]

S. Mousset, N. Derome, and M. Veuille
A Test of Neutrality and Constant Population Size Based on the Mismatch Distribution
Mol. Biol. Evol., April 1, 2004; 21(4): 724 - 731.
[Abstract] [Full Text] [PDF]

L. M. Matzkin
Population Genetics and Geographic Variation of Alcohol Dehydrogenase (Adh) Paralogs and Glucose-6-Phosphate Dehydrogenase (G6pd) in Drosophila mojavensis
Mol. Biol. Evol., February 1, 2004; 21(2): 276 - 285.
[Abstract] [Full Text] [PDF]

G. Zhou, Y. Zhai, X. Dong, X. Zhang, F. He, K. Zhou, Y. Zhu, H. Wei, Z. Yao, S. Zhong, et al.
Haplotype Structure and Evidence for Positive Selection at the Human IL13 Locus
Mol. Biol. Evol., January 1, 2004; 21(1): 29 - 36.
[Abstract] [Full Text] [PDF]

U. Stolz, S. Velez, K. V. Wood, M. Wood, and J. L. Feder
Darwinian natural selection for orange bioluminescent color in a Jamaican click beetle
PNAS, December 9, 2003; 100(25): 14955 - 14959.
[Abstract] [Full Text] [PDF]

E. S. Balakirev and F. J. Ayala
Nucleotide Variation of the Est-6 Gene Region in Natural Populations of Drosophila melanogaster
Genetics, December 1, 2003; 165(4): 1901 - 1914.
[Abstract] [Full Text] [PDF]

M. O. Kauer, D. Dieringer, and C. Schlotterer
A Microsatellite Variability Screen for Positive Selection Associated With the "Out of Africa" Habitat Expansion of Drosophila melanogaster
Genetics, November 1, 2003; 165(3): 1137 - 1148.
[Abstract] [Full Text] [PDF]

K. L. Montooth, J. H. Marden, and A. G. Clark
Mapping Determinants of Variation in Energy Metabolism, Respiration and Flight in Drosophila
Genetics, October 1, 2003; 165(2): 623 - 635.
[Abstract] [Full Text] [PDF]

H. Quesada, U. E. M. Ramirez, J. Rozas, and M. Aguade
Large-Scale Adaptive Hitchhiking Upon High Recombination in Drosophila simulans
Genetics, October 1, 2003; 165(2): 895 - 900.
[Abstract] [Full Text] [PDF]

C. Toomajian, R. S. Ajioka, L. B. Jorde, J. P. Kushner, and M. Kreitman
A Method for Detecting Recent Selection in the Human Genome From Allele Age Estimates
Genetics, September 1, 2003; 165(1): 287 - 297.
[Abstract] [Full Text] [PDF]

D. Charlesworth, B. K. Mable, M. H. Schierup, C. Bartolome, and P. Awadalla
Diversity and Linkage of Genes in the Self-Incompatibility Gene Family in Arabidopsis lyrata
Genetics, August 1, 2003; 164(4): 1519 - 1535.
[Abstract] [Full Text] [PDF]

M. Przeworski
Estimating the Time Since the Fixation of a Beneficial Allele
Genetics, August 1, 2003; 164(4): 1667 - 1676.
[Abstract] [Full Text] [PDF]

H. Innan, B. Padhukasahasram, and M. Nordborg
The Pattern of Polymorphism on Human Chromosome 21
Genome Res., June 1, 2003; 13(6): 1158 - 1168.
[Abstract] [Full Text] [PDF]

J. O. Borevitz and M. Nordborg
The Impact of Genomics on the Study of Natural Variation in Arabidopsis
Plant Physiology, June 1, 2003; 132(2): 718 - 725.
[Full Text] [PDF]

M. Nordborg and H. Innan
The Genealogy of Sequences Containing Multiple Sites Subject to Strong Selection in a Subdivided Population
Genetics, March 1, 2003; 163(3): 1201 - 1213.
[Abstract] [Full Text] [PDF]

A. G. Saez, A. Tatarenkov, E. Barrio, N. H. Becerra, and F. J. Ayala
Patterns of DNA sequence polymorphism at Sod vicinities in Drosophila melanogaster: Unraveling the footprint of a recent selective sweep
PNAS, February 18, 2003; 100(4): 1793 - 1798.
[Abstract] [Full Text] [PDF]

S. Mousset, L. Brazier, M.-L. Cariou, F. Chartois, F. Depaulis, and M. Veuille
Evidence of a High Rate of Selective Sweeps in African Drosophila melanogaster
Genetics, February 1, 2003; 163(2): 599 - 609.
[Abstract] [Full Text] [PDF]

L. M. Matzkin and W. F. Eanes
Sequence Variation of Alcohol Dehydrogenase (Adh) Paralogs in Cactophilic Drosophila
Genetics, January 1, 2003; 163(1): 181 - 194.
[Abstract] [Full Text] [PDF]

L. Zhang, A. S. Peek, D. Dunams, and B. S. Gaut
Population Genetics of Duplicated Disease-Defense Genes, hm1 and hm2, in Maize (Zea mays ssp. mays L.) and Its Wild Ancestor (Zea mays ssp. parviglumis)
Genetics, October 1, 2002; 162(2): 851 - 860.
[Abstract] [Full Text] [PDF]

C. Robin, R. F. Lyman, A. D. Long, C. H. Langley, and T. F. C. Mackay
hairy: A Quantitative Trait Locus for Drosophila Sensory Bristle Number
Genetics, September 1, 2002; 162(1): 155 - 164.
[Abstract] [Full Text] [PDF]

J. Gonzalez, J. M. Ranz, and A. Ruiz
Chromosomal Elements Evolve at Different Rates in the Drosophila Genome
Genetics, July 1, 2002; 161(3): 1137 - 1154.
[Abstract] [Full Text] [PDF]

J. F. Baines, Y. Chen, A. Das, and W. Stephan
DNA Sequence Variation at a Duplicated Gene: Excess of Replacement Polymorphism and Extensive Haplotype Structure in the Drosophila melanogasterbicoid Region
Mol. Biol. Evol., July 1, 2002; 19(7): 989 - 998.
[Abstract] [Full Text] [PDF]

J. M. Comeron and M. Kreitman
Population, Evolutionary and Genomic Consequences of Interference Selection
Genetics, May 1, 2002; 161(1): 389 - 410.
[Abstract] [Full Text] [PDF]

W. Wang, K. Thornton, A. Berry, and M. Long
Nucleotide Variation Along the Drosophila melanogaster Fourth Chromosome
Science, January 4, 2002; 295(5552): 134 - 137.
[Abstract] [Full Text] [PDF]

J. Parsch, C. D. Meiklejohn, and D. L. Hartl
Patterns of DNA Sequence Variation Suggest the Recent Action of Positive Selection in the janus-ocnus Region of Drosophila simulans
Genetics, October 1, 2001; 159(2): 647 - 657.
[Abstract] [Full Text] [PDF]

B. P. Lazzaro and A. G. Clark
Evidence for Recurrent Paralogous Gene Conversion and Exceptional Allelic Divergence in the Attacin Genes of Drosophila melanogaster
Genetics, October 1, 2001; 159(2): 659 - 671.
[Abstract] [Full Text] [PDF]

E. Baudry, C. Kerdelhue, H. Innan, and W. Stephan
Species and Recombination Effects on DNA Variability in the Tomato Genus
Genetics, August 1, 2001; 158(4): 1725 - 1735.
[Abstract] [Full Text] [PDF]

J. Rozas, M. Gullaud, G. Blandin, and M. Aguade
DNA Variation at the rp49 Gene Region of Drosophila simulans: Evolutionary Inferences From an Unusual Haplotype Structure
Genetics, July 1, 2001; 158(3): 1147 - 1155.
[Abstract] [Full Text] [PDF]

B. C. Verrelli and W. F. Eanes
Clinal Variation for Amino Acid Polymorphisms at the Pgm Locus in Drosophila melanogaster
Genetics, April 1, 2001; 157(4): 1649 - 1663.
[Abstract] [Full Text]

G. H. Pogson
Nucleotide Polymorphism and Natural Selection at the Pantophysin (Pan I) Locus in the Atlantic Cod, Gadus morhua (L.)
Genetics, January 1, 2001; 157(1): 317 - 330.
[Abstract] [Full Text]

B. C. Verrelli and W. F. Eanes
Extensive Amino Acid Polymorphism at the Pgm Locus Is Consistent With Adaptive Protein Evolution in Drosophila melanogaster
Genetics, December 1, 2000; 156(4): 1737 - 1752.
[Abstract] [Full Text]

D. D. Duvernell and W. F. Eanes
Contrasting Molecular Population Genetics of Four Hexokinases in Drosophila melanogaster, D. simulans and D. yakuba
Genetics, November 1, 2000; 156(3): 1191 - 1201.
[Abstract] [Full Text]

M. Kovacevic and S. W. Schaeffer
Molecular Population Genetics of X-Linked Genes in Drosophila pseudoobscura
Genetics, September 1, 2000; 156(1): 155 - 172.
[Abstract] [Full Text]

P. Andolfatto and M. Przeworski
A Genome-Wide Departure From the Standard Neutral Model in Natural Populations of Drosophila
Genetics, September 1, 2000; 156(1): 257 - 268.
[Abstract] [Full Text]

J. Vieira and B. Charlesworth
Evidence for Selection at the fused Locus of Drosophila virilis
Genetics, August 1, 2000; 155(4): 1701 - 1709.
[Abstract] [Full Text]

				N. A. Rosenberg and M. Jakobsson The Relationship Between Homozygosity and the Frequency of the Most Frequent Allele Genetics, August 1, 2008; 179(4): 2027 - 2036. [Abstract] [Full Text] [PDF]

				C.-L. Huang, S.-Y. Hwang, Y.-C. Chiang, and T.-P. Lin Molecular Evolution of the Pi-ta Gene Resistant to Rice Blast in Wild Rice (Oryza rufipogon) Genetics, July 1, 2008; 179(3): 1527 - 1538. [Abstract] [Full Text] [PDF]

				P. Pfaffelhuber, A. Lehnert, and W. Stephan Linkage Disequilibrium Under Genetic Hitchhiking in Finite Populations Genetics, May 1, 2008; 179(1): 527 - 537. [Abstract] [Full Text] [PDF]

				N. Derome, E. Baudry, D. Ogereau, M. Veuille, and C. Montchamp-Moreau Selective Sweeps in a 2-Locus Model for Sex-Ratio Meiotic Drive in Drosophila simulans Mol. Biol. Evol., February 1, 2008; 25(2): 409 - 416. [Abstract] [Full Text] [PDF]

				A. L. Evans, P. A. Mena, and B. F. McAllister Positive Selection Near an Inversion Breakpoint on the Neo-X Chromosome of Drosophila americana Genetics, November 1, 2007; 177(3): 1303 - 1319. [Abstract] [Full Text] [PDF]

				K. Zeng, S. Mano, S. Shi, and C.-I Wu Comparisons of Site- and Haplotype-Frequency Methods for Detecting Positive Selection Mol. Biol. Evol., July 1, 2007; 24(7): 1562 - 1574. [Abstract] [Full Text] [PDF]

				E. Tauber, M. Zordan, F. Sandrelli, M. Pegoraro, N. Osterwalder, C. Breda, A. Daga, A. Selmin, K. Monger, C. Benna, et al. Natural Selection Favors a Newly Derived timeless Allele in Drosophila melanogaster Science, June 29, 2007; 316(5833): 1895 - 1898. [Abstract] [Full Text] [PDF]

				A. Sanchez-Gracia and J. Rozas Unusual Pattern of Nucleotide Sequence Variation at the OS-E and OS-F Genomic Regions of Drosophila simulans Genetics, April 1, 2007; 175(4): 1923 - 1935. [Abstract] [Full Text] [PDF]

				G. McVean The Structure of Linkage Disequilibrium Around a Selective Sweep Genetics, March 1, 2007; 175(3): 1395 - 1406. [Abstract] [Full Text] [PDF]

				S. Seixas, G. Suriano, F. Carvalho, R. Seruca, J. Rocha, and A. Di Rienzo Sequence Diversity at the Proximal 14q32.1 SERPIN Subcluster: Evidence for Natural Selection Favoring the Pseudogenization of SERPINA2 Mol. Biol. Evol., February 1, 2007; 24(2): 587 - 598. [Abstract] [Full Text] [PDF]

				K. Zeng, Y.-X. Fu, S. Shi, and C.-I Wu Statistical Tests for Detecting Positive Selection by Utilizing High-Frequency Variants Genetics, November 1, 2006; 174(3): 1431 - 1439. [Abstract] [Full Text] [PDF]

				H. Innan Modified Hudson-Kreitman-Aguade Test and Two-Dimensional Evaluation of Neutrality Tests Genetics, July 1, 2006; 173(3): 1725 - 1733. [Abstract] [Full Text] [PDF]

				P. C. Sabeti, S. F. Schaffner, B. Fry, J. Lohmueller, P. Varilly, O. Shamovsky, A. Palma, T. S. Mikkelsen, D. Altshuler, and E. S. Lander Positive natural selection in the human lineage. Science, June 16, 2006; 312(5780): 1614 - 1620. [Abstract] [Full Text] [PDF]

				S. Beisswanger, W. Stephan, and D. De Lorenzo Evidence for a Selective Sweep in the wapl Region of Drosophila melanogaster Genetics, January 1, 2006; 172(1): 265 - 274. [Abstract] [Full Text] [PDF]

				M. Soejima, H. Tachida, T. Ishida, A. Sano, and Y. Koda Evidence for Recent Positive Selection at the Human AIM1 Locus in a European Population Mol. Biol. Evol., January 1, 2006; 23(1): 179 - 188. [Abstract] [Full Text] [PDF]

				M. A. Saunders, M. Slatkin, C. Garner, M. F. Hammer, and M. W. Nachman The Extent of Linkage Disequilibrium Caused by Selection on G6PD in Humans Genetics, November 1, 2005; 171(3): 1219 - 1229. [Abstract] [Full Text] [PDF]

				C. S. Lim, L. Tazi, and F. J. Ayala Plasmodium vivax: Recent world expansion and genetic identity to Plasmodium simium PNAS, October 25, 2005; 102(43): 15523 - 15528. [Abstract] [Full Text] [PDF]

				P. K. Ingvarsson Molecular Population Genetics of Herbivore-induced Protease Inhibitor Genes in European Aspen (Populus tremula L., Salicaceae) Mol. Biol. Evol., September 1, 2005; 22(9): 1802 - 1812. [Abstract] [Full Text] [PDF]

				P. R. Haddrill, K. R. Thornton, B. Charlesworth, and P. Andolfatto Multilocus patterns of nucleotide variability and the demographic and selection history of Drosophila melanogaster populations Genome Res., June 1, 2005; 15(6): 790 - 799. [Abstract] [Full Text] [PDF]

				H. Innan, K. Zhang, P. Marjoram, S. Tavare, and N. A. Rosenberg Statistical Tests of the Coalescent Model Based on the Haplotype Frequency Distribution and the Number of Segregating Sites Genetics, March 1, 2005; 169(3): 1763 - 1777. [Abstract] [Full Text] [PDF]

				S. J. Macdonald and A. D. Long Identifying Signatures of Selection at the Enhancer of split Neurogenic Gene Complex in Drosophila Mol. Biol. Evol., March 1, 2005; 22(3): 607 - 619. [Abstract] [Full Text] [PDF]

				F. Catania and C. Schlotterer Non-African Origin of a Local Beneficial Mutation in D. melanogaster Mol. Biol. Evol., February 1, 2005; 22(2): 265 - 272. [Abstract] [Full Text] [PDF]

				J. E. Stajich and M. W. Hahn Disentangling the Effects of Demography and Selection in Human History Mol. Biol. Evol., January 1, 2005; 22(1): 63 - 73. [Abstract] [Full Text] [PDF]

				K. K. Shimizu, J. M. Cork, A. L. Caicedo, C. A. Mays, R. C. Moore, K. M. Olsen, S. Ruzsa, G. Coop, C. D. Bustamante, P. Awadalla, et al. Darwinian Selection on a Selfing Locus Science, December 17, 2004; 306(5704): 2081 - 2084. [Abstract] [Full Text] [PDF]

				M. C. Leclerc, P. Durand, C. Gauthier, S. Patot, N. Billotte, M. Menegon, C. Severini, F. J. Ayala, and F. Renaud From The Cover: Meager genetic variability of the human malaria agent Plasmodium vivax PNAS, October 5, 2004; 101(40): 14455 - 14460. [Abstract] [Full Text] [PDF]

				E. Sezgin, D. D. Duvernell, L. M. Matzkin, Y. Duan, C.-T. Zhu, B. C. Verrelli, and W. F. Eanes Single-Locus Latitudinal Clines and Their Relationship to Temperate Adaptation in Metabolic Genes and Derived Alleles in Drosophila melanogaster Genetics, October 1, 2004; 168(2): 923 - 931. [Abstract] [Full Text] [PDF]

				C. D. Meiklejohn, Y. Kim, D. L. Hartl, and J. Parsch Identification of a Locus Under Complex Positive Selection in Drosophila simulans by Haplotype Mapping and Composite-Likelihood Estimation Genetics, September 1, 2004; 168(1): 265 - 279. [Abstract] [Full Text] [PDF]

				E. S. Balakirev and F. J. Ayala Nucleotide Variation in the tinman and bagpipe Homeobox Genes of Drosophila melanogaster Genetics, April 1, 2004; 166(4): 1845 - 1856. [Abstract] [Full Text] [PDF]

				S. Mousset, N. Derome, and M. Veuille A Test of Neutrality and Constant Population Size Based on the Mismatch Distribution Mol. Biol. Evol., April 1, 2004; 21(4): 724 - 731. [Abstract] [Full Text] [PDF]

				L. M. Matzkin Population Genetics and Geographic Variation of Alcohol Dehydrogenase (Adh) Paralogs and Glucose-6-Phosphate Dehydrogenase (G6pd) in Drosophila mojavensis Mol. Biol. Evol., February 1, 2004; 21(2): 276 - 285. [Abstract] [Full Text] [PDF]