- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Dexter, D.
- Articles by Golin, J.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Dexter, D.
- Articles by Golin, J.
Genetics, Vol 136, 505-515, Copyright © 1994
INVESTIGATIONS |
Mutations in the Yeast PDR3, PDR4, PDR7 and PDR9 Pleiotropic (Multiple) Drug Resistance Loci Affect the Transcript Level of an ATP Binding Cassette Transporter Encoding Gene, PDR5
D. Dexter, W. S. Moye-Rowley, A. L. Wu and J. Golin
Department of Biology, The Catholic University of America, Washington, D.C. 20064
The yeast pleiotropic (multiple drug) resistance gene PDR5 encodes a product with homology to a large number of membrane transport proteins including the mammalian multiple drug resistance family. In this study, we identified four genes on chromosome II that affect the steady-state level of PDR5 transcript in addition to a previously identified positive regulator, PDR1. The genes in question are PDR3, PDR4, PDR7 and PDR9. We also analyzed the interaction between PDR5 and YAP1. YAP1 encodes a positive regulator with a leucine zipper motif that causes pleiotropic drug resistance when overproduced. YAP1-mediated pleiotropic drug resistance is not dependent on the presence of PDR5 and must act through other genes.
This article has been cited by other articles:
 |
|
 |
|
  K. Gulshan and W. S. Moye-Rowley Multidrug Resistance in Fungi Eukaryot. Cell, November 1, 2007; 6(11): 1933 - 1942. [Full Text] [PDF]
|
|
|
|
 |
|
 X. J. Chen Activity of the Kluyveromyces lactis Pdr5 Multidrug Transporter Is Modulated by the Sit4 Protein Phosphatase J. Bacteriol., July 1, 2001; 183(13): 3939 - 3948. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. J. Chen, B. E. Bauer, K. Kuchler, and G. D. Clark-Walker Positive and Negative Control of Multidrug Resistance by the Sit4 Protein Phosphatase in Kluyveromyces lactis J. Biol. Chem., May 12, 2000; 275(20): 14865 - 14872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Talibi and M. Raymond Isolation of a Putative Candida albicans Transcriptional Regulator Involved in Pleiotropic Drug Resistance by Functional Complementation of a pdr1 pdr3 Mutation in Saccharomyces cerevisiae J. Bacteriol., January 1, 1999; 181(1): 231 - 240. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Nakaune, K. Adachi, O. Nawata, M. Tomiyama, K. Akutsu, and T. Hibi A Novel ATP-Binding Cassette Transporter Involved in Multidrug Resistance in the Phytopathogenic Fungus Penicillium digitatum Appl. Envir. Microbiol., October 1, 1998; 64(10): 3983 - 3988. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Ogawa, T. Hashida-Okado, M. Endo, H. Yoshioka, T. Tsuruo, K. Takesako, and I. Kato Role of ABC Transporters in Aureobasidin A Resistance Antimicrob. Agents Chemother., April 1, 1998; 42(4): 755 - 761. [Abstract] [Full Text]
|
|
|
|
|
|
T. C. Hallstrom and W. S. Moye-Rowley Divergent Transcriptional Control of Multidrug Resistance Genes in Saccharomyces cerevisiae J. Biol. Chem., January 23, 1998; 273(4): 2098 - 2104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Spataro, T. Toda, R. Craig, M. Seeger, W. Dubiel, A. L. Harris, and C. Norbury Resistance to Diverse Drugs and Ultraviolet Light Conferred by Overexpression of a Novel Human 26 S Proteasome Subunit J. Biol. Chem., November 28, 1997; 272(48): 30470 - 30475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-M. Alarco, I. Balan, D. Talibi, N. Mainville, and M. Raymond AP1-mediated Multidrug Resistance in Saccharomyces cerevisiae Requires FLR1 Encoding a Transporter of the Major Facilitator Superfamily J. Biol. Chem., August 1, 1997; 272(31): 19304 - 19313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Katzmann, T. C. Hallstrom, Y. Mahe, and W. S. Moye-Rowley Multiple Pdr1p/Pdr3p Binding Sites Are Essential for Normal Expression of the ATP Binding Cassette Transporter Protein-encoding Gene PDR5 J. Biol. Chem., September 20, 1996; 271(38): 23049 - 23054. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Martens, J. Genereaux, A. Saleh, and C. J. Brandl Transcriptional Activation by Yeast PDR1p Is Inhibited by Its Association with NGG1p/ADA3p J. Biol. Chem., July 5, 1996; 271(27): 15884 - 15890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-L. Wu, T. C. Hallstrom, and W. S. Moye-Rowley ROD1, a Novel Gene Conferring Multiple Resistance Phenotypes in Saccharomyces cerevisiae J. Biol. Chem., February 9, 1996; 271(6): 2914 - 2920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Decottignies, L. Lambert, P. Catty, H. Degand, E. A. Epping, W. S. Moye-Rowley, E. Balzi, and A. Goffeau Identification and Characterization of SNQ2, a New Multidrug ATP Binding Cassette Transporter of the Yeast Plasma Membrane J. Biol. Chem., July 28, 1995; 270(30): 18150 - 18157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhang, Z. Cui, T. Miyakawa, and W. S. Moye-Rowley Cross-talk between Transcriptional Regulators of Multidrug Resistance in Saccharomyces cerevisiae J. Biol. Chem., March 16, 2001; 276(12): 8812 - 8819. [Abstract] [Full Text] [PDF]
|
|