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Genetics, Vol 135, 1003-1010, Copyright © 1993
INVESTIGATIONS |
Longevity-Determining Genes in Caenorhabditis elegans: Chromosomal Mapping of Multiple Noninteractive Loci
R. H. Ebert-II, V. A. Cherkasova, R. A. Dennis, J. H. Wu, S. Ruggles, T. E. Perrin and R. J. Shmookler-Reis
Department of Medicine and Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, and McClellan Memorial Veterans Hospital, Little Rock, Arkansas 72205
We have used chromosome mapping with polymorphic markers to define genetic components governing life span in the nematode Caenorhabditis elegans. A complex recombinant-inbred population was derived from an interstrain cross, yielding >1000 genotypes, each a composite of homozygous segments from the two parental strains. Genotypes were analyzed for the last-surviving 1-5% of worms in aging cohorts, and for young controls, by multiplex polymerase chain reaction using polymorphic markers to distinguish the parental alleles. We identified five regions of the genome at which one parental allele was significantly enriched in long-lived subpopulations. At four of five loci, the same alleles were selected in aging cohorts maintained under two different conditions, implying that these genes determine life span in differing environments.
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