The Pleiotropic Function of Delta During Postembryonic Development of Drosophila melanogaster

INVESTIGATIONS

The Pleiotropic Function of Delta During Postembryonic Development of Drosophila melanogaster

T. R. Parody and MAT. Muskavitch
Program in Genetics, Cell and Developmental Biology, Department of Biology, Indiana University, Bloomington, Indiana 47405

Analysis of the development of Delta (Dl) temperature-sensitive mutants pulsed at restrictive temperature during larval and pupal stages reveals multiple phenocritical periods during which reduction of Dl function affects viability and development of adult structures. Dl function is required during the third larval instar for post-pupal viability and during the first day of pupal development for viability through eclosion. Dl function is required biphasically for the development of sensory bristles. Earlier pulses lead to bristle multiplication and later pulses lead to bristle loss. The exact intervals during which multiplication and loss are induced vary for different bristles. Dl function is also required for development of most, if not all, cell types in the retina. Different pulses result in reduction in eye size, scarring, and glossiness, as well as multiplication and loss of interommatidial bristles. We also define intervals during which Dl function is required for aspects of leg and wing development. Phenocritical periods for Dl function are temporally coincident with those previously reported for Notch (N), consistent with the hypothesis that the proteins encoded by Dl and N interact throughout development to assure correct specification of cell fates in a variety of imaginal tissues.

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				G. R. Buckles, C. Rauskolb, J. L. Villano, and F. N. Katz four-jointed interacts with dachs, abelson and enabled and feeds back onto the Notch pathway to affect growth and segmentation in the Drosophila leg Development, September 15, 2001; 128(18): 3533 - 3542. [Abstract] [Full Text] [PDF]

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				A. Parks, K. Klueg, J. Stout, and M. Muskavitch Ligand endocytosis drives receptor dissociation and activation in the Notch pathway Development, January 4, 2000; 127(7): 1373 - 1385. [Abstract] [PDF]

				T Ikeya and S Hayashi Interplay of Notch and FGF signaling restricts cell fate and MAPK activation in the Drosophila trachea Development, January 10, 1999; 126(20): 4455 - 4463. [Abstract] [PDF]

				S. Bishop, T Klein, A. Arias, and J. Couso Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch Development, January 7, 1999; 126(13): 2993 - 3003. [Abstract] [PDF]

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				K. M. Klueg, T. R. Parody, and M. A.T. Muskavitch Complex Proteolytic Processing Acts on Delta, a Transmembrane Ligand for Notch, during Drosophila Development Mol. Biol. Cell, July 1, 1998; 9(7): 1709 - 1723. [Abstract] [Full Text]

				J. de Celis, D. Tyler, J de Celis, and S. Bray Notch signalling mediates segmentation of the Drosophila leg Development, January 12, 1998; 125(23): 4617 - 4626. [Abstract] [PDF]

				B Biehs, M. Sturtevant, and E Bier Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs Development, January 11, 1998; 125(21): 4245 - 4257. [Abstract] [PDF]

				T. Jacobsen, K Brennan, A. Arias, and M. Muskavitch Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila Development, January 11, 1998; 125(22): 4531 - 4540. [Abstract] [PDF]

				S. Huppert, T. Jacobsen, and M. Muskavitch Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis Development, January 9, 1997; 124(17): 3283 - 3291. [Abstract] [PDF]

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				K. Cadigan and R Nusse wingless signaling in the Drosophila eye and embryonic epidermis Development, January 9, 1996; 122(9): 2801 - 2812. [Abstract] [PDF]

				J. de Celis, A Garcia-Bellido, and S. Bray Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc Development, January 1, 1996; 122(1): 359 - 369. [Abstract] [PDF]

				S Artavanis-Tsakonas, K Matsuno, and M. Fortini Notch signaling Science, April 14, 1995; 268(5208): 225 - 232. [Abstract] [PDF]

				K Matsuno, R. Diederich, M. Go, C. Blaumueller, and S Artavanis-Tsakonas Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats Development, January 8, 1995; 121(8): 2633 - 2644. [Abstract] [PDF]

				A Singson, M W Leviten, A G Bang, X H Hua, and J W Posakony Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling. Genes & Dev., September 1, 1994; 8(17): 2058 - 2071. [Abstract] [PDF]