- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Vinh, DBN.
- Articles by Drubin, D. G.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Vinh, DBN.
- Articles by Drubin, D. G.
Genetics, Vol 135, 275-286, Copyright © 1993
INVESTIGATIONS |
Genetic Evidence for Functional Interactions Between Actin Noncomplementing (Anc) Gene Products and Actin Cytoskeletal Proteins in Saccharomyces cerevisiae
DBN. Vinh, M. D. Welch, A. K. Corsi, K. F. Wertman and D. G. Drubin
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720
We describe here genetic interactions between mutant alleles of Actin-NonComplementing (ANC) genes and actin (ACT1) or actin-binding protein (SAC6, ABP1, TPM1) genes. The anc mutations were found to exhibit allele-specific noncomplementing interactions with different act1 mutations. In addition, mutant alleles of four ANC genes (ANC1, ANC2, ANC3 and ANC4) were tested for interactions with null alleles of actin-binding protein genes. An anc1 mutant allele failed to complement null alleles of the SAC6 and TPM1 genes that encode yeast fimbrin and tropomyosin, respectively. Also, synthetic lethality between anc3 and sac6 mutations, and between anc4 and tpm1 mutations was observed. Taken together, the above results strongly suggest that the ANC gene products contribute to diverse aspects of actin function. Finally, we report the results of tests of two models previously proposed to explain extragenic noncomplementation.
This article has been cited by other articles:
 |
|
 |
|
  B. Haarer, S. Viggiano, M. A. Hibbs, O. G. Troyanskaya, and D. C. Amberg Modeling complex genetic interactions in a simple eukaryotic genome: actin displays a rich spectrum of complex haploinsufficiencies Genes & Dev., January 15, 2007; 21(2): 148 - 159. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Hawley and W. D. Gilliland Sometimes the Result Is Not the Answer: The Truths and the Lies That Come From Using the Complementation Test Genetics, September 1, 2006; 174(1): 5 - 15. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Baetz, N. J. Krogan, A. Emili, J. Greenblatt, and P. Hieter The ctf13-30/CTF13 Genomic Haploinsufficiency Modifier Screen Identifies the Yeast Chromatin Remodeling Complex RSC, Which Is Required for the Establishment of Sister Chromatid Cohesion Mol. Cell. Biol., February 1, 2004; 24(3): 1232 - 1244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Amin, M.-N. Nguyen, S. Oh, and R. D. Kolodner exo1-Dependent Mutator Mutations: Model System for Studying Functional Interactions in Mismatch Repair Mol. Cell. Biol., August 1, 2001; 21(15): 5142 - 5155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Yook, S. R. Proulx, and E. M. Jorgensen Rules of Nonallelic Noncomplementation at the Synapse in Caenorhabditis elegans Genetics, May 1, 2001; 158(1): 209 - 220. [Abstract] [Full Text]
|
|