- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Stephan, W.
- Articles by Kirby, D. A.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Stephan, W.
- Articles by Kirby, D. A.
Genetics, Vol 135, 97-103, Copyright © 1993
INVESTIGATIONS |
RNA Folding in Drosophila Shows a Distance Effect for Compensatory Fitness Interactions
W. Stephan and D. A. Kirby
Department of Zoology, University of Maryland, College Park, Maryland 20742
Phylogenetic-comparative analysis was used to construct a secondary structure of Adh precursor messenger RNA (pre-mRNA) in Drosophila. The analysis revealed that the rate of coevolution of base-pairing residues decreases with their physical distance. This result is in qualitative agreement with a model of compensatory fitness interactions which assumes that mutations are individually deleterious but become harmless (neutral) in appropriate combinations. This model predicts that coupled mutations can become fixed in a population under mutation pressure and random genetic drift, when the mutations are closely linked. However, the rate of joint fixation drops as distance between sites increases and recombination breaks up favorable combinations. RNA secondary structure was also used to interpret patterns of linkage disequilibrium at Adh.
This article has been cited by other articles:
 |
|
 |
|
  P. Pamilo, L. Viljakainen, and A. Vihavainen Exceptionally High Density of NUMTs in the Honeybee Genome Mol. Biol. Evol., June 1, 2007; 24(6): 1340 - 1346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Poon, B. H. Davis, and L. Chao The Coupon Collector and the Suppressor Mutation: Estimating the Number of Compensatory Mutations by Maximum Likelihood Genetics, July 1, 2005; 170(3): 1323 - 1332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Halligan, A. Eyre-Walker, P. Andolfatto, and P. D. Keightley Patterns of Evolutionary Constraints in Intronic and Intergenic DNA of Drosophila Genome Res., February 1, 2004; 14(2): 273 - 279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Matzkin Population Genetics and Geographic Variation of Alcohol Dehydrogenase (Adh) Paralogs and Glucose-6-Phosphate Dehydrogenase (G6pd) in Drosophila mojavensis Mol. Biol. Evol., February 1, 2004; 21(2): 276 - 285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Baines, J. Parsch, and W. Stephan Pleiotropic Effect of Disrupting a Conserved Sequence Involved in a Long-Range Compensatory Interaction in the Drosophila Adh Gene Genetics, January 1, 2004; 166(1): 237 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. F. McCutchan, D. Rathore, and J. Li Compensatory Evolution in the Human Malaria Parasite Plasmodium ovale Genetics, January 1, 2004; 166(1): 637 - 640. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Chen and W. Stephan Compensatory evolution of a precursor messenger RNA secondary structure in the Drosophila melanogaster Adh gene PNAS, September 30, 2003; 100(20): 11499 - 11504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Hare and S. R. Palumbi High Intron Sequence Conservation Across Three Mammalian Orders Suggests Functional Constraints Mol. Biol. Evol., June 1, 2003; 20(6): 969 - 978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Matzkin and W. F. Eanes Sequence Variation of Alcohol Dehydrogenase (Adh) Paralogs in Cactophilic Drosophila Genetics, January 1, 2003; 163(1): 181 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Llopart, J. M. Comeron, F. G. Brunet, D. Lachaise, and M. Long Intron presence-absence polymorphism in Drosophila driven by positive Darwinian selection PNAS, June 11, 2002; 99(12): 8121 - 8126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-Y. Wang and S.-C. Lee Secondary Structure of Mitochondrial 12S rRNA Among Fish and Its Phylogenetic Applications Mol. Biol. Evol., February 1, 2002; 19(2): 138 - 148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Innan and W. Stephan Selection Intensity Against Deleterious Mutations in RNA Secondary Structures and Rate of Compensatory Nucleotide Substitutions Genetics, September 1, 2001; 159(1): 389 - 399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Comeron and M. Kreitman The Correlation Between Intron Length and Recombination in Drosophila: Dynamic Equilibrium Between Mutational and Selective Forces Genetics, November 1, 2000; 156(3): 1175 - 1190. [Abstract] [Full Text]
|
|
|
|
|
|
J. Parsch, J. M. Braverman, and W. Stephan Comparative Sequence Analysis and Patterns of Covariation in RNA Secondary Structures Genetics, February 1, 2000; 154(2): 909 - 921. [Abstract] [Full Text]
|
|
|
|
|
|
E. S. Balakirev, E. I. Balakirev, F. Rodríguez-Trelles, and F. J. Ayala Molecular Evolution of Two Linked Genes, Est-6 and Sod, in Drosophila melanogaster Genetics, November 1, 1999; 153(3): 1357 - 1369. [Abstract] [Full Text]
|
|
|
|
|
|
A. Llopart and M. Aguadé Synonymous Rates at the RpII215 Gene of Drosophila: Variation Among Species and Across the Coding Region Genetics, May 1, 1999; 152(1): 269 - 280. [Abstract] [Full Text]
|
|
|
|
|
|
J. Parsch, S. Tanda, and W. Stephan Site-directed mutations reveal long-range compensatory interactions in the Adh gene of Drosophila melanogaster PNAS, February 4, 1997; 94(3): 928 - 933. [Abstract] [Full Text] [PDF]
|
|