P-lacW Insertional Mutagenesis on the Second Chromosome of Drosophila melanogaster: Isolation of Lethals With Different Overgrowth Phenotypes

INVESTIGATIONS

P-lacW Insertional Mutagenesis on the Second Chromosome of Drosophila melanogaster: Isolation of Lethals With Different Overgrowth Phenotypes

T. Torok, G. Tick, M. Alvarado and I. Kiss
Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, H-6701, Szeged, Hungary

A single P-element insertional mutagenesis experiment was carried out for the second chromosome of Drosophila melanogaster using the P-lacW transposon. Out of 15,475 insertions on the second chromosome, 2,308 lethal and 403 semilethal mutants (altogether 2,711) were recovered. After eliminating clusters, 72% of the mutants represent independent insertions. Some of the mutants with larval, prepupal or pupal lethal phases have a prolonged larval period and show gradual overgrowth of the imaginal discs, brain and/or the hematopoietic organs (lymph glands). In this paper, 16 overgrowth mutants are described. As revealed by in situ hybridization, none of the mutations corresponds to any of the previously known overgrowth mutations on the second chromosome.

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				S. U. Astrom, T. W. Cline, and J. Rine The Drosophila melanogaster sir2+ Gene Is Nonessential and Has Only Minor Effects on Position-Effect Variegation Genetics, March 1, 2003; 163(3): 931 - 937. [Abstract] [Full Text] [PDF]

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				B. L. Newman, J. R. Lundblad, Y. Chen, and S. M. Smolik A Drosophila Homologue of Sir2 Modifies Position-Effect Variegation but Does Not Affect Life Span Genetics, December 1, 2002; 162(4): 1675 - 1685. [Abstract] [Full Text] [PDF]

				N. Remillieux-Leschelle, P. Santamaria, and N. B. Randsholt Regulation of Larval Hematopoiesis in Drosophila melanogaster: A Role for the multi sex combs Gene Genetics, November 1, 2002; 162(3): 1259 - 1274. [Abstract] [Full Text] [PDF]

				R. B. Green, V. Hatini, K. A. Johansen, X.-J. Liu, and J. A. Lengyel Drumstick is a zinc finger protein that antagonizes Lines to control patterning and morphogenesis of the Drosophila hindgut Development, August 1, 2002; 129(15): 3645 - 3656. [Abstract] [Full Text] [PDF]

				K. Simin, A. Scuderi, J. Reamey, D. Dunn, R. Weiss, J. E. Metherall, and A. Letsou Profiling Patterned Transcripts in Drosophila Embryos Genome Res., July 1, 2002; 12(7): 1040 - 1047. [Abstract] [Full Text] [PDF]

				H. Schenkel, S. Hanke, C. De Lorenzo, R. Schmitt, and B. M. Mechler P Elements Inserted in the Vicinity of or Within the Drosophila snRNP SmD3 Gene Nested in the First Intron of the Ornithine Decarboxylase Antizyme Gene Affect Only the Expression of SmD3 Genetics, June 1, 2002; 161(2): 763 - 772. [Abstract] [Full Text] [PDF]

				J. D. Schnorr, R. Holdcraft, B. Chevalier, and C. A. Berg Ras1 Interacts With Multiple New Signaling and Cytoskeletal Loci in Drosophila Eggshell Patterning and Morphogenesis Genetics, October 1, 2001; 159(2): 609 - 622. [Abstract] [Full Text] [PDF]

				P. V. Benos, M. K. Gatt, L. Murphy, D. Harris, B. Barrell, C. Ferraz, S. Vidal, C. Brun, J. Demaille, E. Cadieu, et al. From First Base: The Sequence of the Tip of the X Chromosome of Drosophila melanogaster, a Comparison of Two Sequencing Strategies Genome Res., May 1, 2001; 11(5): 710 - 730. [Abstract] [Full Text]

				H.Y. E. Chan, S. Brogna, and C. J. O'Kane Dribble, the Drosophila KRR1p Homologue, Is Involved in rRNA Processing Mol. Biol. Cell, May 1, 2001; 12(5): 1409 - 1419. [Abstract] [Full Text]

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				A. J. Whittaker, I. Royzman, and T. L. Orr-Weaver Drosophila Double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts Genes & Dev., July 15, 2000; 14(14): 1765 - 1776. [Abstract] [Full Text]

				B. A. Bour, M. Chakravarti, J. M. West, and S. M. Abmayr Drosophila SNS, a member of the immunoglobulin superfamily that is essential for myoblast fusion Genes & Dev., June 15, 2000; 14(12): 1498 - 1511. [Abstract] [Full Text]

				D. Price, S. Rabinovitch, P. H. O'Farrell, and S. D. Campbell Drosophila wee1 Has an Essential Role in the Nuclear Divisions of Early Embryogenesis Genetics, May 1, 2000; 155(1): 159 - 166. [Abstract] [Full Text]

				S. Lee, K.-L. Harris, P. M. Whitington, and P. A. Kolodziej short stop Is Allelic to kakapo, and Encodes Rod-Like Cytoskeletal-Associated Proteins Required for Axon Extension J. Neurosci., February 1, 2000; 20(3): 1096 - 1108. [Abstract] [Full Text] [PDF]