- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Gavrilets, S.
- Articles by Hastings, A.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Gavrilets, S.
- Articles by Hastings, A.
Genetics, Vol 134, 377-386, Copyright © 1993
INVESTIGATIONS |
Maintenance of Genetic Variability Under Strong Stabilizing Selection: A Two-Locus Model
S. Gavrilets and A. Hastings
Division of Environmental Studies, University of California, Davis, California 95616, N. I. Vavilov Institute of General Genetics, 117809 GSP-1, Moscow B-333, Russia
We study a two locus model with additive contributions to the phenotype to explore the relationship between stabilizing selection and recombination. We show that if the double heterozygote has the optimum phenotype and the contributions of the loci to the trait are different, then any symmetric stabilizing selection fitness function can maintain genetic variability provided selection is sufficiently strong relative to linkage. We present results of a detailed analysis of the quadratic fitness function which show that selection need not be extremely strong relative to recombination for the polymorphic equilibria to be stable. At these polymorphic equilibria the mean value of the trait, in general, is not equal to the optimum phenotype, there exists a large level of negative linkage disequilibrium which ``hides'' additive genetic variance, and different equilibria can be stable simultaneously. We analyze dependence of different characteristics of these equilibria on the location of optimum phenotype, on the difference in allelic effect, and on the strength of selection relative to recombination. Our overall result that stabilizing selection does not necessarily eliminate genetic variability is compatible with some experimental results where the lines subject to strong stabilizing selection did not have significant reductions in genetic variability.
This article has been cited by other articles:
 |
|
 |
|
  R. Burger and A. Gimelfarb The Effects of Intraspecific Competition and Stabilizing Selection on a Polygenic Trait Genetics, July 1, 2004; 167(3): 1425 - 1443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bürger and A. Gimelfarb Genetic Variation Maintained in Multilocus Models of Additive Quantitative Traits Under Stabilizing Selection Genetics, July 1, 1999; 152(2): 807 - 820. [Abstract] [Full Text]
|
|